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RhoGAP92B Rho GTPase activating protein at 92B [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42371, updated on 18-Sep-2024

Summary

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Official Symbol
RhoGAP92Bprovided by FlyBase
Official Full Name
Rho GTPase activating protein at 92Bprovided by FlyBase
Primary source
FLYBASE:FBgn0038747
Locus tag
Dmel_CG4755
See related
AllianceGenome:FB:FBgn0038747
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG4755; Dmel\CG4755; drich; dRich
Summary
Enables GTPase activator activity and SH3 domain binding activity. Involved in several processes, including positive regulation of BMP secretion; positive regulation of synaptic assembly at neuromuscular junction; and subsynaptic reticulum organization. Located in neuromuscular junction. Is expressed in adult head; organism; pole plasm; primary trachea; and tarsal segment. Orthologous to several human genes including ARHGAP44 (Rho GTPase activating protein 44) and SH3BP1 (SH3 domain binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See RhoGAP92B in Genome Data Viewer
Location:
92B6-92B6; 3-67 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (19905164..19914272)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (15730886..15739994)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Caseinolytic protease chaperone subunit Neighboring gene Surfeit 6 Neighboring gene long non-coding RNA:CR45047 Neighboring gene long non-coding RNA:CR45048 Neighboring gene exit protein of rhodopsin and TRP B Neighboring gene exit protein of rhodopsin and TRP A Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Modulation of the cell membrane lipid milieu by peroxisomal β-oxidation induces Rho1 signaling to trigger inflammatory responses. Nath AS, et al. Cell Rep, 2022 Mar 1. PMID 35235794
  2. Inference of RhoGAP/GTPase regulation using single-cell morphological data from a combinatorial RNAi screen. Nir O, et al. Genome Res, 2010 Mar. PMID 20144944, Free PMC Article
  3. Feedback inhibition of actin on Rho mediates content release from large secretory vesicles. Segal D, et al. J Cell Biol, 2018 May 7. PMID 29496739, Free PMC Article
  4. Conundrum, an ARHGAP18 orthologue, regulates RhoA and proliferation through interactions with Moesin. Neisch AL, et al. Mol Biol Cell, 2013 May. PMID 23468526, Free PMC Article
  5. The Cdc42-selective GAP rich regulates postsynaptic development and retrograde BMP transsynaptic signaling. Nahm M, et al. J Cell Biol, 2010 Nov 1. PMID 21041451, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables SH3 domain binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables phospholipid binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in imaginal disc-derived leg morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of actin filament polymerization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of small GTPase mediated signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuromuscular synaptic transmission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of synaptic assembly at neuromuscular junction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of Rac protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in subsynaptic reticulum organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in neuromuscular junction IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Rho GTPase activating protein at 92B
Names
CG4755-PA
CG4755-PB
CG4755-PC
CG4755-PD
CG4755-PE
RhoGAP92B-PA
RhoGAP92B-PB
RhoGAP92B-PC
RhoGAP92B-PD
RhoGAP92B-PE

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    19905164..19914272
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001300488.1 → NP_001287417.1  Rho GTPase activating protein at 92B, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287417.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8T3Q3, Q9VDS5
    UniProtKB/TrEMBL
    B5RIZ2
    Conserved Domains (2) summary
    cd04386
    Location:245 → 452
    RhoGAP_nadrin; RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been ...
    cl12013
    Location:27 → 257
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  2. NM_142587.3 → NP_650844.1  Rho GTPase activating protein at 92B, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650844.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8T3Q3, Q9VDS5
    UniProtKB/TrEMBL
    B5RIZ2
    Related
    FBpp0083230
    Conserved Domains (2) summary
    cd04386
    Location:245 → 452
    RhoGAP_nadrin; RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been ...
    cl12013
    Location:27 → 257
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  3. NM_001300485.1 → NP_001287414.1  Rho GTPase activating protein at 92B, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287414.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LHC1
    Conserved Domains (2) summary
    cd07595
    Location:27 → 257
    BAR_RhoGAP_Rich-like; The Bin/Amphiphysin/Rvs (BAR) domain of Rich-like Rho GTPase Activating Proteins
    cd04386
    Location:245 → 452
    RhoGAP_nadrin; RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been ...

  4. NM_001300487.1 → NP_001287416.1  Rho GTPase activating protein at 92B, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287416.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LHN0
    Conserved Domains (2) summary
    cd04386
    Location:153 → 360
    RhoGAP_nadrin; RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been ...
    cl12013
    Location:1 → 165
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  5. NM_001300486.1 → NP_001287415.1  Rho GTPase activating protein at 92B, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287415.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LHC3
    Conserved Domains (2) summary
    cd04386
    Location:48 → 255
    RhoGAP_nadrin; RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been ...
    cl12013
    Location:1 → 59
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4LHC1 A0A0B4LHC1
A0A0B4LHC3 A0A0B4LHC3
A0A0B4LHN0 A0A0B4LHN0
B5RIZ2 B5RIZ2
Q9VDS5.1 Q9VDS5

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