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TA3 TALPID3 [ Gallus gallus (chicken) ]

Gene ID: 423540, updated on 17-Aug-2024

Summary

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Official Symbol
TA3provided by CGNC
Official Full Name
TALPID3provided by CGNC
Primary source
CGNC:9115
See related
Ensembl:ENSGALG00010017341
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
KIAA0586
Orthologs
human mouse all
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Genomic context

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See TA3 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
33
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 5 NC_052536.1 (54741289..54805660, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 5 NC_052577.1 (54780912..54846792, complement)

Chromosome 5 - NC_052536.1Genomic Context describing neighboring genes Neighboring gene dishevelled binding antagonist of beta catenin 1 Neighboring gene uncharacterized LOC112532566 Neighboring gene uncharacterized LOC107053581 Neighboring gene microRNA 1578 Neighboring gene uncharacterized LOC124418383 Neighboring gene uncharacterized LOC121111032 Neighboring gene translocase of inner mitochondrial membrane 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Loss of cilia causes embryonic lung hypoplasia, liver fibrosis, and cholestasis in the talpid3 ciliopathy mutant. Davey MG, et al. Organogenesis, 2014 Apr-Jun. PMID 24743779, Free PMC Article
  2. Failure of centrosome migration causes a loss of motile cilia in talpid(3) mutants. Stephen LA, et al. Dev Dyn, 2013 Aug. PMID 23613203
  3. Analysis of talpid3 and wild-type chicken embryos reveals roles for Hedgehog signalling in development of the limb bud vasculature. Davey MG, et al. Dev Biol, 2007 Jan 1. PMID 16959240
  4. Craniofacial development in the talpid3 chicken mutant. Buxton P, et al. Differentiation, 2004 Sep. PMID 15554946
  5. Expression of transcription factor c-Rel and apoptosis occurrence in polydactylous and syndactylous limb buds of the talpid3 mutant chick embryo. Huguet C, et al. Apoptosis, 1999 Feb. PMID 14634293

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The talpid(3) chicken represents a useful resource in furthering our understanding of the pathology of ciliopathies.
    Title: Loss of cilia causes embryonic lung hypoplasia, liver fibrosis, and cholestasis in the talpid3 ciliopathy mutant.
  2. Talpid3 is one of a growing number of centrosomal proteins that affect both ciliogenesis and Hh signalling.
    Title: The Talpid3 gene (KIAA0586) encodes a centrosomal protein that is essential for primary cilia formation.
  3. talpid3 protein operates in the cytoplasm to regulate the activity of both Gli repressor and activator proteins.
    Title: The chicken talpid3 gene encodes a novel protein essential for Hedgehog signaling.
  4. talpid(3) gene product encodes a novel protein essential for Hedgehog signalling which is required for both activator and repressor functions of Gli transcription factors
    Title: Analysis of talpid3 and wild-type chicken embryos reveals roles for Hedgehog signalling in development of the limb bud vasculature.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Process Evidence Code Pubs
involved_in smoothened signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in centriole IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in ciliary basal body IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
TALPID3 protein
Names
ortholog of chicken talpid{3}
protein TALPID3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040707.2 → NP_001035797.2  TALPID3 protein

    Status: PROVISIONAL

    Source sequence(s)
    JAENSK010000215
    UniProtKB/TrEMBL
    A0A8V0Z226
    Conserved Domains (1) summary
    PHA03269
    Location:1126 → 1234
    PHA03269; envelope glycoprotein C; Provisional

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052536.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    54741289..54805660 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040701078.2 → XP_040557012.1  TALPID3 protein isoform X2

    UniProtKB/TrEMBL
    A0A8V0Z226
    Conserved Domains (1) summary
    PHA03269
    Location:1126 → 1234
    PHA03269; envelope glycoprotein C; Provisional

  2. XM_015287504.4 → XP_015142990.2  TALPID3 protein isoform X3

    UniProtKB/TrEMBL
    A0A8V0Z226
    Related
    ENSGALP00010024492.1, ENSGALT00010041873.1
    Conserved Domains (1) summary
    PHA03269
    Location:1126 → 1234
    PHA03269; envelope glycoprotein C; Provisional

  3. XM_040701077.2 → XP_040557011.1  TALPID3 protein isoform X1

    UniProtKB/TrEMBL
    A0A8V0Z226
    Conserved Domains (1) summary
    PHA03269
    Location:1126 → 1234
    PHA03269; envelope glycoprotein C; Provisional

  4. XM_040701080.2 → XP_040557014.1  TALPID3 protein isoform X6

    UniProtKB/TrEMBL
    A0A8V0Z090
    Related
    ENSGALP00010024455.1, ENSGALT00010041822.1
    Conserved Domains (1) summary
    PHA03269
    Location:1126 → 1234
    PHA03269; envelope glycoprotein C; Provisional

  5. XM_040701079.2 → XP_040557013.1  TALPID3 protein isoform X4

    UniProtKB/TrEMBL
    A0A8V0Z0N4
    Conserved Domains (1) summary
    PHA03269
    Location:1126 → 1234
    PHA03269; envelope glycoprotein C; Provisional

  6. XM_015287506.4 → XP_015142992.2  TALPID3 protein isoform X5

    UniProtKB/TrEMBL
    A0A8V0Z0N4
    Related
    ENSGALP00010024468.1, ENSGALT00010041838.1
    Conserved Domains (1) summary
    PHA03269
    Location:1126 → 1234
    PHA03269; envelope glycoprotein C; Provisional

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052577.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    54780912..54846792 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046918758.1 → XP_046774714.1  TALPID3 protein isoform X7

    UniProtKB/Swiss-Prot
    F1NQN0, Q1G7G9

  2. XM_046918753.1 → XP_046774709.1  TALPID3 protein isoform X2

    UniProtKB/Swiss-Prot
    F1NQN0, Q1G7G9

  3. XM_046918754.1 → XP_046774710.1  TALPID3 protein isoform X3

    UniProtKB/Swiss-Prot
    F1NQN0, Q1G7G9

  4. XM_046918751.1 → XP_046774707.1  TALPID3 protein isoform X1

    UniProtKB/Swiss-Prot
    F1NQN0, Q1G7G9

  5. XM_046918757.1 → XP_046774713.1  TALPID3 protein isoform X6

    UniProtKB/TrEMBL
    A0A8V0Z090

  6. XM_046918755.1 → XP_046774711.1  TALPID3 protein isoform X4

    UniProtKB/TrEMBL
    A0A8V0Z0N4

  7. XM_046918756.1 → XP_046774712.1  TALPID3 protein isoform X5

    UniProtKB/TrEMBL
    A0A8V0Z0N4
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q1G7G9.2 GenPept UniProtKB/Swiss-Prot:Q1G7G9

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