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MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog [ Gallus gallus (chicken) ]

Gene ID: 421948, updated on 10-Oct-2024

Summary

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Symbol
MYCNprovided by CGNC
Full Name
v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homologprovided by CGNC
Primary source
CGNC:12325
See related
Ensembl:ENSGALG00010003652
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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See MYCN in Genome Data Viewer
Location:
chromosome: 3
Exon count:
4
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 3 NC_052534.1 (98927265..98931920)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 3 NC_052575.1 (98742553..98747209)

Chromosome 3 - NC_052534.1Genomic Context describing neighboring genes Neighboring gene DEAD-box helicase 1 Neighboring gene uncharacterized LOC121110402 Neighboring gene uncharacterized LOC121110305 Neighboring gene family with sequence similarity 49 member A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Organization and expression of the chicken N-myc gene. Sawai S, et al. Mol Cell Biol, 1990 May. PMID 2183017, Free PMC Article
  2. MYC proteins promote neuronal differentiation by controlling the mode of progenitor cell division. Zinin N, et al. EMBO Rep, 2014 Apr. PMID 24599748, Free PMC Article
  3. Contrasting patterns of c-myc and N-myc expression in proliferating, quiescent, and differentiating cells of the embryonic chicken lens. Harris LL, et al. Development, 1992 Jul. PMID 1339339
  4. A large database of chicken bursal ESTs as a resource for the analysis of vertebrate gene function. Abdrakhmanov I, et al. Genome Res, 2000 Dec. PMID 11116100, Free PMC Article
  5. A comprehensive collection of chicken cDNAs. Boardman PE, et al. Curr Biol, 2002 Nov 19. PMID 12445392

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. An unexpected role of MYC proteins in the control of stemness versus differentiation of neural stem cells in vivo.
    Title: MYC proteins promote neuronal differentiation by controlling the mode of progenitor cell division.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
N-myc proto-oncogene protein
Names
MYCN proto-oncogene, bHLH transcription factor
N-myc protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001398099.1 → NP_001385028.1  N-myc proto-oncogene protein

    Status: VALIDATED

    Source sequence(s)
    AJ395839, BU135131, BU334398, CR385166, HAEK01081628, JAENSK010000066
    UniProtKB/TrEMBL
    E1C3E1
    Related
    ENSGALP00010004966.1, ENSGALT00010008458.1
    Conserved Domains (2) summary
    cd11456
    Location:355 → 441
    bHLHzip_N-Myc_like; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in N-Myc and similar proteins
    pfam01056
    Location:2 → 349
    Myc_N; Myc amino-terminal region

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052534.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    98927265..98931920
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015276044.4 → XP_015131530.1  N-myc proto-oncogene protein isoform X1

    UniProtKB/Swiss-Prot
    P18444
    UniProtKB/TrEMBL
    E1C3E1
    Conserved Domains (2) summary
    cd11456
    Location:355 → 441
    bHLHzip_N-Myc_like; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in N-Myc and similar proteins
    pfam01056
    Location:2 → 349
    Myc_N; Myc amino-terminal region

  2. XM_015276049.4 → XP_015131535.1  N-myc proto-oncogene protein isoform X1

    UniProtKB/Swiss-Prot
    P18444
    UniProtKB/TrEMBL
    E1C3E1
    Conserved Domains (2) summary
    cd11456
    Location:355 → 441
    bHLHzip_N-Myc_like; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in N-Myc and similar proteins
    pfam01056
    Location:2 → 349
    Myc_N; Myc amino-terminal region

  3. XM_046938932.1 → XP_046794888.1  N-myc proto-oncogene protein isoform X1

    UniProtKB/TrEMBL
    E1C3E1

  4. XM_015276046.4 → XP_015131532.1  N-myc proto-oncogene protein isoform X1

    UniProtKB/Swiss-Prot
    P18444
    UniProtKB/TrEMBL
    E1C3E1
    Conserved Domains (2) summary
    cd11456
    Location:355 → 441
    bHLHzip_N-Myc_like; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in N-Myc and similar proteins
    pfam01056
    Location:2 → 349
    Myc_N; Myc amino-terminal region

  5. XM_015276048.4 → XP_015131534.1  N-myc proto-oncogene protein isoform X1

    UniProtKB/Swiss-Prot
    P18444
    UniProtKB/TrEMBL
    E1C3E1
    Conserved Domains (2) summary
    cd11456
    Location:355 → 441
    bHLHzip_N-Myc_like; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in N-Myc and similar proteins
    pfam01056
    Location:2 → 349
    Myc_N; Myc amino-terminal region

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052575.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    98742553..98747209
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046914168.1 → XP_046770124.1  N-myc proto-oncogene protein isoform X1

  2. XM_046914171.1 → XP_046770127.1  N-myc proto-oncogene protein isoform X1

  3. XM_046914172.1 → XP_046770128.1  N-myc proto-oncogene protein isoform X1

  4. XM_046914169.1 → XP_046770125.1  N-myc proto-oncogene protein isoform X1

  5. XM_046914170.1 → XP_046770126.1  N-myc proto-oncogene protein isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001031091.3: Suppressed sequence

    Description
    NM_001031091.3: This RefSeq was removed because currently there is insufficient support for the transcript
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P18444.1 GenPept UniProtKB/Swiss-Prot:P18444

Gene LinkOut

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Research Materials