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IBTK inhibitor of Bruton tyrosine kinase [ Gallus gallus (chicken) ]

Gene ID: 421844, updated on 17-Aug-2024

Summary

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Official Symbol
IBTKprovided by CGNC
Official Full Name
inhibitor of Bruton tyrosine kinaseprovided by CGNC
Primary source
CGNC:11835
See related
Ensembl:ENSGALG00010003180
Gene type
protein coding
RefSeq status
MODEL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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See IBTK in Genome Data Viewer
Location:
chromosome: 3
Exon count:
30
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 3 NC_052534.1 (77948398..78002920)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 3 NC_052575.1 (77740232..77794852)

Chromosome 3 - NC_052534.1Genomic Context describing neighboring genes Neighboring gene ubiquitin protein ligase E3D Neighboring gene trophoblast glycoprotein Neighboring gene uncharacterized LOC112532207 Neighboring gene uncharacterized LOC107053113 Neighboring gene family with sequence similarity 46 member A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein tyrosine kinase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
inhibitor of Bruton tyrosine kinase
Names
inhibitor of Bruton agammaglobulinemia tyrosine kinase

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052534.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    77948398..78002920
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_419865.8 → XP_419865.2  inhibitor of Bruton tyrosine kinase isoform X1

    See identical proteins and their annotated locations for XP_419865.2

    UniProtKB/TrEMBL
    A0A3Q2U7Z3, A0A8V0XIB5
    Conserved Domains (8) summary
    smart00225
    Location:768 → 870
    BTB; Broad-Complex, Tramtrack and Bric a brac
    COG5184
    Location:239 → 460
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00204
    Location:47 → 136
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd14821
    Location:870 → 915
    SPOP_C_like; BACK-like Domain C-terminal to BTB in speckle-type POZ protein (SPOP) and similar proteins
    pfam00415
    Location:248 → 300
    RCC1; Regulator of chromosome condensation (RCC1) repeat
    pfam00651
    Location:759 → 866
    BTB; BTB/POZ domain
    pfam12796
    Location:25 → 117
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:51 → 83
    ANK; ANK repeat [structural motif]

  2. XM_004940418.5 → XP_004940475.1  inhibitor of Bruton tyrosine kinase isoform X2

    UniProtKB/TrEMBL
    A0A8V0XIB5
    Conserved Domains (8) summary
    smart00225
    Location:768 → 870
    BTB; Broad-Complex, Tramtrack and Bric a brac
    COG5184
    Location:239 → 460
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00204
    Location:47 → 136
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd14821
    Location:870 → 915
    SPOP_C_like; BACK-like Domain C-terminal to BTB in speckle-type POZ protein (SPOP) and similar proteins
    pfam00415
    Location:248 → 300
    RCC1; Regulator of chromosome condensation (RCC1) repeat
    pfam00651
    Location:759 → 866
    BTB; BTB/POZ domain
    pfam12796
    Location:25 → 117
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:51 → 83
    ANK; ANK repeat [structural motif]

  3. XM_004940419.5 → XP_004940476.1  inhibitor of Bruton tyrosine kinase isoform X4

    UniProtKB/TrEMBL
    A0A3Q3AWN9, A0A8V0XIB5
    Related
    ENSGALP00010004443.1, ENSGALT00010007426.1
    Conserved Domains (8) summary
    smart00225
    Location:768 → 870
    BTB; Broad-Complex, Tramtrack and Bric a brac
    COG5184
    Location:239 → 460
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00204
    Location:47 → 136
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd14821
    Location:870 → 915
    SPOP_C_like; BACK-like Domain C-terminal to BTB in speckle-type POZ protein (SPOP) and similar proteins
    pfam00415
    Location:248 → 300
    RCC1; Regulator of chromosome condensation (RCC1) repeat
    pfam00651
    Location:759 → 866
    BTB; BTB/POZ domain
    pfam12796
    Location:25 → 117
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:51 → 83
    ANK; ANK repeat [structural motif]

  4. XM_040697719.2 → XP_040553653.1  inhibitor of Bruton tyrosine kinase isoform X3

    UniProtKB/TrEMBL
    A0A8V0XIB5
    Conserved Domains (6) summary
    COG0666
    Location:47 → 153
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    COG5184
    Location:145 → 317
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    sd00045
    Location:51 → 83
    ANK; ANK repeat [structural motif]
    cd18301
    Location:547 → 654
    BTB1_POZ_IBtk; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk)
    cd18302
    Location:734 → 845
    BTB2_POZ_IBtk; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk)
    cd18500
    Location:841 → 900
    BACK_IBtk; BACK (BTB and C-terminal Kelch) domain found in inhibitor of Bruton tyrosine kinase (IBtk)

  5. XM_004940417.5 → XP_004940474.1  inhibitor of Bruton tyrosine kinase isoform X1

    See identical proteins and their annotated locations for XP_004940474.1

    UniProtKB/TrEMBL
    A0A3Q2U7Z3, A0A8V0XIB5
    Related
    ENSGALP00010004436.1, ENSGALT00010007419.1
    Conserved Domains (8) summary
    smart00225
    Location:768 → 870
    BTB; Broad-Complex, Tramtrack and Bric a brac
    COG5184
    Location:239 → 460
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00204
    Location:47 → 136
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd14821
    Location:870 → 915
    SPOP_C_like; BACK-like Domain C-terminal to BTB in speckle-type POZ protein (SPOP) and similar proteins
    pfam00415
    Location:248 → 300
    RCC1; Regulator of chromosome condensation (RCC1) repeat
    pfam00651
    Location:759 → 866
    BTB; BTB/POZ domain
    pfam12796
    Location:25 → 117
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:51 → 83
    ANK; ANK repeat [structural motif]

RNA

  1. XR_005858392.2 RNA Sequence

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052575.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    77740232..77794852
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040666939.2 → XP_040522873.1  inhibitor of Bruton tyrosine kinase isoform X1

    UniProtKB/TrEMBL
    A0A8V0XIB5
    Conserved Domains (6) summary
    COG0666
    Location:47 → 153
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    COG5184
    Location:145 → 317
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    sd00045
    Location:51 → 83
    ANK; ANK repeat [structural motif]
    cd18301
    Location:547 → 654
    BTB1_POZ_IBtk; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk)
    cd18302
    Location:762 → 874
    BTB2_POZ_IBtk; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk)
    cd18500
    Location:870 → 929
    BACK_IBtk; BACK (BTB and C-terminal Kelch) domain found in inhibitor of Bruton tyrosine kinase (IBtk)

  2. XM_040666941.2 → XP_040522875.1  inhibitor of Bruton tyrosine kinase isoform X2

    UniProtKB/TrEMBL
    A0A8V0XIB5
    Conserved Domains (6) summary
    COG0666
    Location:47 → 153
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    COG5184
    Location:145 → 317
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    sd00045
    Location:51 → 83
    ANK; ANK repeat [structural motif]
    cd18301
    Location:547 → 654
    BTB1_POZ_IBtk; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk)
    cd18302
    Location:762 → 874
    BTB2_POZ_IBtk; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk)
    cd18500
    Location:870 → 929
    BACK_IBtk; BACK (BTB and C-terminal Kelch) domain found in inhibitor of Bruton tyrosine kinase (IBtk)

  3. XM_040666943.2 → XP_040522877.1  inhibitor of Bruton tyrosine kinase isoform X4

    UniProtKB/TrEMBL
    A0A8V0XIB5
    Conserved Domains (6) summary
    COG0666
    Location:47 → 153
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    COG5184
    Location:145 → 317
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    sd00045
    Location:51 → 83
    ANK; ANK repeat [structural motif]
    cd18301
    Location:547 → 654
    BTB1_POZ_IBtk; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk)
    cd18302
    Location:762 → 874
    BTB2_POZ_IBtk; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk)
    cd18500
    Location:870 → 929
    BACK_IBtk; BACK (BTB and C-terminal Kelch) domain found in inhibitor of Bruton tyrosine kinase (IBtk)

  4. XM_040666942.2 → XP_040522876.1  inhibitor of Bruton tyrosine kinase isoform X3

    UniProtKB/TrEMBL
    A0A8V0XIB5
    Conserved Domains (6) summary
    COG0666
    Location:47 → 153
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    COG5184
    Location:145 → 317
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    sd00045
    Location:51 → 83
    ANK; ANK repeat [structural motif]
    cd18301
    Location:547 → 654
    BTB1_POZ_IBtk; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk)
    cd18302
    Location:734 → 845
    BTB2_POZ_IBtk; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk)
    cd18500
    Location:841 → 900
    BACK_IBtk; BACK (BTB and C-terminal Kelch) domain found in inhibitor of Bruton tyrosine kinase (IBtk)

  5. XM_040666940.2 → XP_040522874.1  inhibitor of Bruton tyrosine kinase isoform X1

    UniProtKB/TrEMBL
    A0A8V0XIB5
    Conserved Domains (6) summary
    COG0666
    Location:47 → 153
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    COG5184
    Location:145 → 317
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    sd00045
    Location:51 → 83
    ANK; ANK repeat [structural motif]
    cd18301
    Location:547 → 654
    BTB1_POZ_IBtk; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk)
    cd18302
    Location:762 → 874
    BTB2_POZ_IBtk; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk)
    cd18500
    Location:870 → 929
    BACK_IBtk; BACK (BTB and C-terminal Kelch) domain found in inhibitor of Bruton tyrosine kinase (IBtk)

RNA

  1. XR_005848050.2 RNA Sequence

Nucleotide Protein
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