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PPM1B protein phosphatase, Mg2+/Mn2+ dependent 1B [ Gallus gallus (chicken) ]

Gene ID: 421404, updated on 17-Aug-2024

Summary

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Symbol
PPM1Bprovided by CGNC
Full Name
protein phosphatase, Mg2+/Mn2+ dependent 1Bprovided by CGNC
Primary source
CGNC:7577
See related
Ensembl:ENSGALG00010020386
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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See PPM1B in Genome Data Viewer
Location:
chromosome: 3
Exon count:
16
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 3 NC_052534.1 (25100646..25159203)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 3 NC_052575.1 (25027616..25086189)

Chromosome 3 - NC_052534.1Genomic Context describing neighboring genes Neighboring gene leucine rich pentatricopeptide repeat containing Neighboring gene circumsporozoite protein-like Neighboring gene uncharacterized LOC121110335 Neighboring gene prolyl endopeptidase-like Neighboring gene uncharacterized LOC121113160 Neighboring gene solute carrier family 3 member 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Exosomal miR-181a-5p reduce Mycoplasma gallisepticum (HS strain) infection in chicken by targeting PPM1B and activating the TLR2-mediated MyD88/NF-κB signaling pathway. Sun Y, et al. Mol Immunol, 2021 Dec. PMID 34715577
  2. Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis. Caldwell RB, et al. Genome Biol, 2005. PMID 15642098, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Exosomal miR-181a-5p reduce Mycoplasma gallisepticum (HS strain) infection in chicken by targeting PPM1B and activating the TLR2-mediated MyD88/NF-kappaB signaling pathway.
    Title: Exosomal miR-181a-5p reduce Mycoplasma gallisepticum (HS strain) infection in chicken by targeting PPM1B and activating the TLR2-mediated MyD88/NF-κB signaling pathway.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables manganese ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of canonical NF-kappaB signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of canonical NF-kappaB signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
protein phosphatase 1B
NP_001026223.1
NP_001383695.1
NP_001383696.1
NP_001383697.1
NP_001383698.1
NP_001383699.1
NP_001383700.1
NP_001383701.1
NP_001383702.1
NP_001383703.1
NP_001383704.1
NP_001383705.1
NP_001383706.1
NP_001383707.1
XP_015139173.2
XP_015139176.2
XP_040553003.1
XP_046769731.1
XP_046769732.1
XP_046769733.1
XP_046769734.1
XP_046769736.1
XP_046769737.1
XP_046769738.1
XP_046769739.1
XP_046769740.1
XP_046769741.1
XP_046769742.1
XP_046769743.1
XP_046769744.1
XP_046769745.1
XP_046769746.1
XP_046769747.1
XP_046769748.1
XP_046769749.1
XP_046769750.1
XP_046769751.1
XP_046769752.1
XP_046794752.1
XP_046794753.1
XP_046794754.1
XP_046794755.1
XP_046794756.1
XP_046794757.1
XP_046794758.1
XP_046794759.1
XP_046794760.1
XP_046794761.1
XP_046794762.1
XP_046794763.1
XP_046794764.1
XP_046794765.1
XP_046794766.1
XP_046794767.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001031052.2 → NP_001026223.1  protein phosphatase 1B isoform b

    See identical proteins and their annotated locations for NP_001026223.1

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000063
    UniProtKB/TrEMBL
    A0A1D5PF07, F1NM90, Q5F397
    Conserved Domains (2) summary
    cd00143
    Location:23 → 295
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    pfam07830
    Location:289 → 368
    PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain

  2. NM_001396766.1 → NP_001383695.1  protein phosphatase 1B isoform a

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000063
    UniProtKB/TrEMBL
    A0A8V0ZE41
    Conserved Domains (2) summary
    cd00143
    Location:23 → 295
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    pfam07830
    Location:289 → 368
    PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain

  3. NM_001396767.1 → NP_001383696.1  protein phosphatase 1B isoform a

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000063
    UniProtKB/TrEMBL
    A0A8V0ZE41
    Related
    ENSGALP00010029121.1, ENSGALT00010049267.1
    Conserved Domains (2) summary
    cd00143
    Location:23 → 295
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    pfam07830
    Location:289 → 368
    PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain

  4. NM_001396768.1 → NP_001383697.1  protein phosphatase 1B isoform a

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000063
    UniProtKB/TrEMBL
    A0A8V0ZE41
    Conserved Domains (2) summary
    cd00143
    Location:23 → 295
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    pfam07830
    Location:289 → 368
    PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain

  5. NM_001396769.1 → NP_001383698.1  protein phosphatase 1B isoform a

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000063
    UniProtKB/TrEMBL
    A0A8V0ZE41
    Conserved Domains (2) summary
    cd00143
    Location:23 → 295
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    pfam07830
    Location:289 → 368
    PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain

  6. NM_001396770.1 → NP_001383699.1  protein phosphatase 1B isoform a

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000063
    UniProtKB/TrEMBL
    A0A8V0ZE41
    Conserved Domains (2) summary
    cd00143
    Location:23 → 295
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    pfam07830
    Location:289 → 368
    PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain

  7. NM_001396771.1 → NP_001383700.1  protein phosphatase 1B isoform a

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000063
    UniProtKB/TrEMBL
    A0A8V0ZE41
    Conserved Domains (2) summary
    cd00143
    Location:23 → 295
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    pfam07830
    Location:289 → 368
    PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain

  8. NM_001396772.1 → NP_001383701.1  protein phosphatase 1B isoform b

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000063
    UniProtKB/TrEMBL
    A0A1D5PF07, F1NM90, Q5F397
    Conserved Domains (2) summary
    cd00143
    Location:23 → 295
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    pfam07830
    Location:289 → 368
    PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain

  9. NM_001396773.1 → NP_001383702.1  protein phosphatase 1B isoform b

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000063
    UniProtKB/TrEMBL
    A0A1D5PF07, F1NM90, Q5F397
    Conserved Domains (2) summary
    cd00143
    Location:23 → 295
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    pfam07830
    Location:289 → 368
    PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain

  10. NM_001396774.1 → NP_001383703.1  protein phosphatase 1B isoform b

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000063
    UniProtKB/TrEMBL
    A0A1D5PF07, F1NM90, Q5F397
    Conserved Domains (2) summary
    cd00143
    Location:23 → 295
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    pfam07830
    Location:289 → 368
    PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain

  11. NM_001396775.1 → NP_001383704.1  protein phosphatase 1B isoform b

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000063
    UniProtKB/TrEMBL
    A0A1D5PF07, F1NM90, Q5F397
    Conserved Domains (2) summary
    cd00143
    Location:23 → 295
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    pfam07830
    Location:289 → 368
    PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain

  12. NM_001396776.1 → NP_001383705.1  protein phosphatase 1B isoform b

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000063
    UniProtKB/TrEMBL
    A0A1D5PF07, F1NM90, Q5F397
    Conserved Domains (2) summary
    cd00143
    Location:23 → 295
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    pfam07830
    Location:289 → 368
    PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain

  13. NM_001396777.1 → NP_001383706.1  protein phosphatase 1B isoform b

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000063
    UniProtKB/TrEMBL
    A0A1D5PF07, F1NM90, Q5F397
    Related
    ENSGALP00010029122.1, ENSGALT00010049269.1
    Conserved Domains (2) summary
    cd00143
    Location:23 → 295
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    pfam07830
    Location:289 → 368
    PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain

  14. NM_001396778.1 → NP_001383707.1  protein phosphatase 1B isoform b

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000063
    UniProtKB/TrEMBL
    A0A1D5PF07, F1NM90, Q5F397
    Conserved Domains (2) summary
    cd00143
    Location:23 → 295
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    pfam07830
    Location:289 → 368
    PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052534.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    25100646..25159203
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046938809.1 → XP_046794765.1  protein phosphatase 1B isoform X2

  2. XM_046938796.1 → XP_046794752.1  protein phosphatase 1B isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZE41

  3. XM_015283687.4 → XP_015139173.2  protein phosphatase 1B isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZE41
    Conserved Domains (2) summary
    cd00143
    Location:23 → 295
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    pfam07830
    Location:289 → 368
    PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain

  4. XM_046938804.1 → XP_046794760.1  protein phosphatase 1B isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZE41

  5. XM_046938808.1 → XP_046794764.1  protein phosphatase 1B isoform X2

  6. XM_046938810.1 → XP_046794766.1  protein phosphatase 1B isoform X2

  7. XM_046938807.1 → XP_046794763.1  protein phosphatase 1B isoform X2

  8. XM_046938811.1 → XP_046794767.1  protein phosphatase 1B isoform X2

  9. XM_015283690.4 → XP_015139176.2  protein phosphatase 1B isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZE41
    Conserved Domains (2) summary
    cd00143
    Location:23 → 295
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    pfam07830
    Location:289 → 368
    PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain

  10. XM_046938798.1 → XP_046794754.1  protein phosphatase 1B isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZE41

  11. XM_046938806.1 → XP_046794762.1  protein phosphatase 1B isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZE41

  12. XM_046938803.1 → XP_046794759.1  protein phosphatase 1B isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZE41

  13. XM_046938797.1 → XP_046794753.1  protein phosphatase 1B isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZE41

  14. XM_046938805.1 → XP_046794761.1  protein phosphatase 1B isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZE41

  15. XM_046938799.1 → XP_046794755.1  protein phosphatase 1B isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZE41

  16. XM_046938800.1 → XP_046794756.1  protein phosphatase 1B isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZE41

  17. XM_046938801.1 → XP_046794757.1  protein phosphatase 1B isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZE41

  18. XM_046938802.1 → XP_046794758.1  protein phosphatase 1B isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZE41

  19. XM_040697069.2 → XP_040553003.1  protein phosphatase 1B isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZE41
    Conserved Domains (2) summary
    cd00143
    Location:23 → 295
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    pfam07830
    Location:289 → 368
    PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052575.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    25027616..25086189
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046913796.1 → XP_046769752.1  protein phosphatase 1B isoform X3

    UniProtKB/TrEMBL
    A0A1D5PF07, F1NM90, Q5F397

  2. XM_046913781.1 → XP_046769737.1  protein phosphatase 1B isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZE41

  3. XM_046913793.1 → XP_046769749.1  protein phosphatase 1B isoform X2

  4. XM_046913776.1 → XP_046769732.1  protein phosphatase 1B isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZE41

  5. XM_046913775.1 → XP_046769731.1  protein phosphatase 1B isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZE41

  6. XM_046913787.1 → XP_046769743.1  protein phosphatase 1B isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZE41

  7. XM_046913792.1 → XP_046769748.1  protein phosphatase 1B isoform X2

  8. XM_046913794.1 → XP_046769750.1  protein phosphatase 1B isoform X2

  9. XM_046913791.1 → XP_046769747.1  protein phosphatase 1B isoform X2

  10. XM_046913795.1 → XP_046769751.1  protein phosphatase 1B isoform X2

  11. XM_046913784.1 → XP_046769740.1  protein phosphatase 1B isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZE41

  12. XM_046913778.1 → XP_046769734.1  protein phosphatase 1B isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZE41

  13. XM_046913790.1 → XP_046769746.1  protein phosphatase 1B isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZE41

  14. XM_046913786.1 → XP_046769742.1  protein phosphatase 1B isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZE41

  15. XM_046913777.1 → XP_046769733.1  protein phosphatase 1B isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZE41

  16. XM_046913788.1 → XP_046769744.1  protein phosphatase 1B isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZE41

  17. XM_046913780.1 → XP_046769736.1  protein phosphatase 1B isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZE41

  18. XM_046913782.1 → XP_046769738.1  protein phosphatase 1B isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZE41

  19. XM_046913783.1 → XP_046769739.1  protein phosphatase 1B isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZE41

  20. XM_046913785.1 → XP_046769741.1  protein phosphatase 1B isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZE41

  21. XM_046913789.1 → XP_046769745.1  protein phosphatase 1B isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZE41
Nucleotide Protein Strain
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