Det Deterin [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Detprovided by FlyBase
Official Full Name: Deterinprovided by FlyBase
Primary source: FLYBASE:FBgn0264291
Locus tag: Dmel_CG12265
See related: AllianceGenome:FB:FBgn0264291
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG12265; det; Dmel\CG12265; scpo; svn
Summary: Involved in several processes, including cytoskeleton-dependent cytokinesis; meiotic chromosome segregation; and spindle organization. Located in cytoplasm; kinetochore; and spindle midzone. Part of chromosome passenger complex. Is expressed in several structures, including embryonic brain; female germline cell; and gonad. Human ortholog(s) of this gene implicated in prostate cancer; pulmonary hypertension; and transitional cell carcinoma. Orthologous to human BIRC5 (baculoviral IAP repeat containing 5). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (17149667..17150455)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (12975389..12976177)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Process	Evidence Code	Pubs
involved_in actomyosin contractile ring assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromosome segregation	IBA Inferred from Biological aspect of Ancestor more info
involved_in meiosis I cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiosis II cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic chromosome segregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic cytokinesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic spindle organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic spindle organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of apoptotic process	TAS Traceable Author Statement more info	PubMed
involved_in spindle assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of chromosome passenger complex	IBA Inferred from Biological aspect of Ancestor more info
part_of chromosome passenger complex	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome, centromeric region	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in kinetochore	IBA Inferred from Biological aspect of Ancestor more info
located_in kinetochore	IDA Inferred from Direct Assay more info	PubMed
located_in meiotic spindle midzone	IDA Inferred from Direct Assay more info	PubMed
located_in mitotic spindle midzone	IDA Inferred from Direct Assay more info	PubMed
is_active_in spindle midzone	IBA Inferred from Biological aspect of Ancestor more info