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MTOR mechanistic target of rapamycin [ Gallus gallus (chicken) ]

Gene ID: 419455, updated on 17-Aug-2024

Summary

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Symbol
MTORprovided by CGNC
Full Name
mechanistic target of rapamycinprovided by CGNC
Primary source
CGNC:2430
See related
Ensembl:ENSGALG00010021746
Gene type
protein coding
RefSeq status
MODEL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
FRAP1
Orthologs
human mouse all
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Genomic context

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See MTOR in Genome Data Viewer
Location:
chromosome: 21
Exon count:
58
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 21 NC_052552.1 (4128908..4191557, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 21 NC_052593.1 (4162049..4224128, complement)

Chromosome 21 - NC_052552.1Genomic Context describing neighboring genes Neighboring gene spermidine synthase Neighboring gene exosome component 10 Neighboring gene angiopoietin like 7 Neighboring gene UbiA prenyltransferase domain containing 1 Neighboring gene pleckstrin homology and RUN domain containing M2 Neighboring gene solute carrier family 25 member 34 Neighboring gene transmembrane protein 82

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. mTor signaling is required for the formation of proliferating Müller glia-derived progenitor cells in the chick retina. Zelinka CP, et al. Development, 2016 Jun 1. PMID 27068108, Free PMC Article
  2. L-arginine upregulates the gene expression of target of rapamycin signaling pathway and stimulates protein synthesis in chicken intestinal epithelial cells. Yuan C, et al. Poult Sci, 2015 May. PMID 25771531
  3. Activation of mammalian target of rapamycin signaling in skeletal muscle of neonatal chicks: effects of dietary leucine and age. Deng H, et al. Poult Sci, 2014 Jan. PMID 24570430
  4. Effects of breed and dietary nutrient density on the growth performance, blood metabolite, and genes expression of target of rapamycin (TOR) signalling pathway of female broiler chickens. Wang XQ, et al. J Anim Physiol Anim Nutr (Berl), 2013 Aug. PMID 22731106
  5. Copper or/and arsenic induces autophagy by oxidative stress-related PI3K/AKT/mTOR pathways and cascaded mitochondrial fission in chicken skeletal muscle. Wang Y, et al. J Inorg Biochem, 2018 Nov. PMID 30096535

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. miRNA-29-3p targets PTEN to regulate follicular development through the PI3K/Akt/mTOR signaling pathway.
    Title: miRNA-29-3p targets PTEN to regulate follicular development through the PI3K/Akt/mTOR signaling pathway.
  2. results showed that after Cu or/and As insult and accumulation, inhibited PI3K/AKT/mTOR pathway activated autophagy and disturbed mitochondrial dynamic, forming a positive feedback with redox disorder.
    Title: Copper or/and arsenic induces autophagy by oxidative stress-related PI3K/AKT/mTOR pathways and cascaded mitochondrial fission in chicken skeletal muscle.
  3. mTor signaling is required, but not sufficient, to stimulate Muller glia to give rise to proliferating progenitors.
    Title: mTor signaling is required for the formation of proliferating Müller glia-derived progenitor cells in the chick retina.
  4. The body weight gain and breast muscle yield of light chicks were improved by increasing dietary Methionine levels probably through alterations of MSTN transcription and phosphorylation of mTOR and FoxO4.
    Title: MSTN, mTOR and FoxO4 are involved in the enhancement of breast muscle growth by methionine in broilers with lower hatching weight.
  5. This study evaluated the effects of L-Arg on protein synthesis and genes expression involved in target of rapamycin (TOR) signaling pathway in chicken enterocytes.
    Title: L-arginine upregulates the gene expression of target of rapamycin signaling pathway and stimulates protein synthesis in chicken intestinal epithelial cells.
  6. High dietary leucine activates mTOR signaling pathways in skeletal muscle of neonatal chicks to stimulate muscle protein synthesis, and this pathway is attenuated with aging.
    Title: Activation of mammalian target of rapamycin signaling in skeletal muscle of neonatal chicks: effects of dietary leucine and age.
  7. These findings suggested that different genotypes respond differently to changes in dietary nutrient density and that lower-nutrient-density diets are optimal for the long-term housing of broiler chickens.
    Title: Effects of breed and dietary nutrient density on the growth performance, blood metabolite, and genes expression of target of rapamycin (TOR) signalling pathway of female broiler chickens.
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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in TOR signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of macroautophagy IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of TORC1 complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of TORC2 complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
serine/threonine-protein kinase mTOR
Names
FK506 binding protein 12-rapamycin associated protein 1
mechanistic target of rapamycin (serine/threonine kinase)
XP_040545102.1
XP_417614.3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052552.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    4128908..4191557 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_417614.8 → XP_417614.3  serine/threonine-protein kinase mTOR

    UniProtKB/TrEMBL
    F1NUX4
    Related
    ENSGALP00010031768.1, ENSGALT00010052862.1
    Conserved Domains (2) summary
    COG5032
    Location:349 → 2521
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    sd00044
    Location:641 → 667
    HEAT; HEAT repeat [structural motif]

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052593.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    4162049..4224128 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040689168.2 → XP_040545102.1  serine/threonine-protein kinase mTOR

    UniProtKB/TrEMBL
    F1NUX4
    Conserved Domains (2) summary
    COG5032
    Location:349 → 2521
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    sd00044
    Location:641 → 667
    HEAT; HEAT repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version

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