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NCK1 NCK adaptor protein 1 [ Gallus gallus (chicken) ]

Gene ID: 418727, updated on 10-Oct-2024

Summary

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Symbol
NCK1provided by CGNC
Full Name
NCK adaptor protein 1provided by CGNC
Primary source
CGNC:50836
See related
Ensembl:ENSGALG00010012944
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
NCK2
Orthologs
human mouse all
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Genomic context

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See NCK1 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
10
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 1 NC_052532.1 (135390801..135473859)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 1 NC_052573.1 (135347861..135430882)

Chromosome 1 - NC_052532.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101751432 Neighboring gene uncharacterized LOC107051986 Neighboring gene uncharacterized LOC121106671 Neighboring gene uncharacterized LOC107051985 Neighboring gene C2orf40 homolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Nck2 is essential for limb trajectory selection by spinal motor axons. Chang CJ, et al. Dev Dyn, 2018 Sep. PMID 30016580
  2. Splenic gene expression profiling in White Leghorn layer inoculated with the Salmonella enterica serovar Enteritidis. Wu G, et al. Anim Genet, 2015 Dec. PMID 26358731
  3. Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis. Caldwell RB, et al. Genome Biol, 2005. PMID 15642098, Free PMC Article
  4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of PERK-mediated unfolded protein response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of translation in response to endoplasmic reticulum stress IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
cytoplasmic protein NCK2
Names
NCK adaptor protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001030814.2 → NP_001025985.2  cytoplasmic protein NCK2

    Status: PROVISIONAL

    Source sequence(s)
    JAENSK010000025
    UniProtKB/TrEMBL
    F1P4Q4, Q5ZK48
    Related
    ENSGALP00010018059.1, ENSGALT00010031063.1
    Conserved Domains (4) summary
    cd10409
    Location:283 → 380
    SH2_Nck2; Src homology 2 (SH2) domain found in Nck
    cd11899
    Location:2 → 59
    SH3_Nck2_1; First Src Homology 3 domain of Nck2 adaptor protein
    cd11902
    Location:114 → 168
    SH3_Nck2_2; Second Src Homology 3 domain of Nck2 adaptor protein
    cd11903
    Location:198 → 256
    SH3_Nck2_3; Third Src Homology 3 domain of Nck2 adaptor protein

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052532.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    135390801..135473859
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046941053.1 → XP_046797009.1  cytoplasmic protein NCK2 isoform X1

    UniProtKB/TrEMBL
    F1P4Q4

  2. XM_046941073.1 → XP_046797029.1  cytoplasmic protein NCK2 isoform X1

    UniProtKB/TrEMBL
    F1P4Q4

  3. XM_040699199.2 → XP_040555133.1  cytoplasmic protein NCK2 isoform X1

    UniProtKB/TrEMBL
    F1P4Q4, Q5ZK48
    Related
    ENSGALP00010018068.1, ENSGALT00010031073.1
    Conserved Domains (4) summary
    cd10409
    Location:283 → 380
    SH2_Nck2; Src homology 2 (SH2) domain found in Nck
    cd11899
    Location:2 → 59
    SH3_Nck2_1; First Src Homology 3 domain of Nck2 adaptor protein
    cd11902
    Location:114 → 168
    SH3_Nck2_2; Second Src Homology 3 domain of Nck2 adaptor protein
    cd11903
    Location:198 → 256
    SH3_Nck2_3; Third Src Homology 3 domain of Nck2 adaptor protein

  4. XM_046941063.1 → XP_046797019.1  cytoplasmic protein NCK2 isoform X1

    UniProtKB/TrEMBL
    F1P4Q4

  5. XM_046941057.1 → XP_046797013.1  cytoplasmic protein NCK2 isoform X1

    UniProtKB/TrEMBL
    F1P4Q4

  6. XM_046941077.1 → XP_046797033.1  cytoplasmic protein NCK2 isoform X1

    UniProtKB/TrEMBL
    F1P4Q4

  7. XM_046941055.1 → XP_046797011.1  cytoplasmic protein NCK2 isoform X1

    UniProtKB/TrEMBL
    F1P4Q4

  8. XM_046941065.1 → XP_046797021.1  cytoplasmic protein NCK2 isoform X1

    UniProtKB/TrEMBL
    F1P4Q4

  9. XM_046941059.1 → XP_046797015.1  cytoplasmic protein NCK2 isoform X1

    UniProtKB/TrEMBL
    F1P4Q4

  10. XM_046941060.1 → XP_046797016.1  cytoplasmic protein NCK2 isoform X1

    UniProtKB/TrEMBL
    F1P4Q4

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052573.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    135347861..135430882
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046908072.1 → XP_046764028.1  cytoplasmic protein NCK2 isoform X1

    UniProtKB/TrEMBL
    F1P4Q4

  2. XM_046908079.1 → XP_046764035.1  cytoplasmic protein NCK2 isoform X1

    UniProtKB/TrEMBL
    F1P4Q4

  3. XM_046908073.1 → XP_046764029.1  cytoplasmic protein NCK2 isoform X1

    UniProtKB/TrEMBL
    F1P4Q4

  4. XM_046908077.1 → XP_046764033.1  cytoplasmic protein NCK2 isoform X1

    UniProtKB/TrEMBL
    F1P4Q4

  5. XM_046908075.1 → XP_046764031.1  cytoplasmic protein NCK2 isoform X1

    UniProtKB/TrEMBL
    F1P4Q4

  6. XM_046908080.1 → XP_046764036.1  cytoplasmic protein NCK2 isoform X1

    UniProtKB/TrEMBL
    F1P4Q4

  7. XM_046908074.1 → XP_046764030.1  cytoplasmic protein NCK2 isoform X1

    UniProtKB/TrEMBL
    F1P4Q4

  8. XM_046908078.1 → XP_046764034.1  cytoplasmic protein NCK2 isoform X1

    UniProtKB/TrEMBL
    F1P4Q4

  9. XM_046908076.1 → XP_046764032.1  cytoplasmic protein NCK2 isoform X1

    UniProtKB/TrEMBL
    F1P4Q4
Nucleotide Protein Strain
Heading Accession and Version

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