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Trax Translin associated factor X [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41871, updated on 2-Nov-2024

Summary

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Official Symbol
Traxprovided by FlyBase
Official Full Name
Translin associated factor Xprovided by FlyBase
Primary source
FLYBASE:FBgn0038327
Locus tag
Dmel_CG5063
See related
AllianceGenome:FB:FBgn0038327
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG5063; Dmel\CG5063; trax; TRAX
Summary
Enables RNA endonuclease activity. Located in cytoplasm. Is expressed in several structures, including CNS glial cell; central brain primordium; embryonic central brain; embryonic central brain neurons; and ganglia. Orthologous to human TSNAX (translin associated factor X). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See Trax in Genome Data Viewer
Location:
88F1-88F1; 3-57 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15361692..15362850)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11187414..11188540)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Transmembrane O-mannosyltransferase targeting cadherins 4 Neighboring gene Autophagy-related 4b Neighboring gene 3-hydroxyisobutyryl-CoA hydrolase Neighboring gene Component of oligomeric golgi complex 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Multimeric assembly and biochemical characterization of the Trax-translin endonuclease complex. Tian Y, et al. Nat Struct Mol Biol, 2011 Jun. PMID 21552261, Free PMC Article
  2. Structural insights into Drosophila-C3PO complex assembly and 'Dynamic Side Port' model in substrate entry and release. Mo X, et al. Nucleic Acids Res, 2018 Sep 19. PMID 29860349, Free PMC Article
  3. C3PO, an endoribonuclease that promotes RNAi by facilitating RISC activation. Liu Y, et al. Science, 2009 Aug 7. PMID 19661431, Free PMC Article
  4. Functional characterization of Drosophila Translin and Trax. Claussen M, et al. Genetics, 2006 Nov. PMID 17028328, Free PMC Article
  5. The long and short of antiviral defense: small RNA-based immunity in insects. Bronkhorst AW, et al. Curr Opin Virol, 2014 Aug. PMID 24732439

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Findings indicate that the loss of Translin/TRAX complex (dmC3PO) promoted the accumulation of the passenger strand of esi-2.1 (hp-CG4068B) and increased the accumulation of miR-bantam.
    Title: Opposite effects of Drosophila C3PO on gene silencing mediated by esi-2.1 and miRNA-bantam.
  2. These studies establish that Trax adopts the translin fold, possesses catalytic centers essential for C3PO's endoRNase activity and interacts extensively with translin to form an octameric assembly.
    Title: Multimeric assembly and biochemical characterization of the Trax-translin endonuclease complex.
  3. an RNAi regulator that we term C3PO (component 3 promoter of RISC), a complex of Translin and Trax was purified; C3PO is a Mg2+-dependent endoribonuclease that promotes RISC activation by removing siRNA passenger strand cleavage products
    Title: C3PO, an endoribonuclease that promotes RNAi by facilitating RISC activation.
  4. A translin null mutant was generated and a trax nonsense mutation was isolated. Translin is essential for stabilizing its interaction with trax.
    Title: Functional characterization of Drosophila Translin and Trax.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA endonuclease activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
translin associated factor X
Names
CG5063-PB
CG5063-PC
Translin-associated factor X
Trax-PB
Trax-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    15361692..15362850
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142197.5 → NP_650454.2  translin associated factor X, isoform C [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    D0IQD7, Q1W1G2, Q8INE1, Q961W6, Q9VF77
    Conserved Domains (1) summary
    cd14805
    Location:37 → 267
    Translin-like; Translin and translin-associated factor-X (TRAX)

  2. NM_169650.3 → NP_732021.2  translin associated factor X, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732021.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    D0IQD7, Q1W1G2, Q8INE1, Q961W6, Q9VF77
    Conserved Domains (1) summary
    cd14805
    Location:37 → 267
    Translin-like; Translin and translin-associated factor-X (TRAX)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7K5N5 Q7K5N5
Q9VF77 Q9VF77

Gene LinkOut

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