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Mau2 Mau2 sister chromatid cohesion factor [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41830, updated on 2-Nov-2024

Summary

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Official Symbol
Mau2provided by FlyBase
Official Full Name
Mau2 sister chromatid cohesion factorprovided by FlyBase
Primary source
FLYBASE:FBgn0038300
Locus tag
Dmel_CG4203
See related
AllianceGenome:FB:FBgn0038300
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG4203; Dmel\CG4203; FBgn0038300; mau-2; Mau-2; MAU-2; MAU2
Summary
Predicted to enable double-stranded DNA binding activity. Predicted to be involved in axon guidance and maintenance of mitotic sister chromatid cohesion. Predicted to be located in chromatin and nucleoplasm. Predicted to be part of SMC loading complex. Orthologous to human MAU2 (MAU2 sister chromatid cohesion factor). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See Mau2 in Genome Data Viewer
Location:
88E3-88E3; 3-56 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15209204..15211347)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11034926..11037069)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Serpin 88Ea Neighboring gene Serpin 88Eb Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Shal Interactor of Di-Leucine Motif Neighboring gene uncharacterized protein Neighboring gene mir-9383 stem loop

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. mau-2 acts cell-autonomously to guide axonal migrations in Caenorhabditis elegans. Bénard CY, et al. Development, 2004 Dec. PMID 15539489
  2. Drosophila nipped-B protein supports sister chromatid cohesion and opposes the stromalin/Scc3 cohesion factor to facilitate long-range activation of the cut gene. Rollins RA, et al. Mol Cell Biol, 2004 Apr. PMID 15060134, Free PMC Article
  3. Cohesin, gene expression and development: lessons from Drosophila. Dorsett D. Chromosome Res, 2009. PMID 19308700, Free PMC Article
  4. The Drosophila melanogaster model for Cornelia de Lange syndrome: Implications for etiology and therapeutics. Dorsett D. Am J Med Genet C Semin Med Genet, 2016 Jun. PMID 27097273, Free PMC Article
  5. Full circle: a brief history of cohesin and the regulation of gene expression. Horsfield JA. FEBS J, 2023 Apr. PMID 35048511

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in axon guidance ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in maintenance of mitotic sister chromatid cohesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in maintenance of mitotic sister chromatid cohesion ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in mitotic sister chromatid cohesion IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of SMC loading complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SMC loading complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in chromatin ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
Mau2 sister chromatid cohesion factor
Names
CG4203-PA
Mau2-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    15209204..15211347
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142171.4 → NP_650428.1  Mau2 sister chromatid cohesion factor [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650428.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VFC0
    Related
    FBpp0082507
    Conserved Domains (1) summary
    pfam10345
    Location:14 → 563
    Cohesin_load; Cohesin loading factor
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VFC0.1 Q9VFC0

Gene LinkOut

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