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DMB2 major histocompatibility complex B, class II beta chain DMB2 [ Gallus gallus (chicken) ]

Gene ID: 417051, updated on 17-Aug-2024

Summary

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Official Symbol
DMB2provided by CGNC
Official Full Name
major histocompatibility complex B, class II beta chain DMB2provided by CGNC
Primary source
CGNC:50422
See related
Ensembl:ENSGALG00010003830
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
BMA2; B-MA2; B-DMB2; B-DMAB2; HLA-DMB
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Genomic context

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See DMB2 in Genome Data Viewer
Location:
chromosome: 16
Exon count:
6
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 16 NC_052547.1 (2209752..2212783)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 16 NC_052588.1 (1110880..1113912)

Chromosome 16 - NC_052547.1Genomic Context describing neighboring genes Neighboring gene bromodomain containing 2 Neighboring gene major histocompatibility complex B, class II alpha chain DMA Neighboring gene major histocompatibility complex B, class II beta chain DMB1 Neighboring gene major histocompatibility complex B, class I heavy chain BF1 Neighboring gene transporter 1, ATP binding cassette subfamily B member, MHCB region

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Organisation and diversity of the class II DM region of the chicken MHC. Chazara O, et al. Mol Immunol, 2011 May. PMID 21481938
  2. Contribution of mutation, recombination, and gene conversion to chicken MHC-B haplotype diversity. Hosomichi K, et al. J Immunol, 2008 Sep 1. PMID 18714011, Free PMC Article
  3. Extended gene map reveals tripartite motif, C-type lectin, and Ig superfamily type genes within a subregion of the chicken MHC-B affecting infectious disease. Shiina T, et al. J Immunol, 2007 Jun 1. PMID 17513765

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables MHC class II protein complex binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in immunoglobulin production involved in immunoglobulin-mediated immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in peptide antigen assembly with MHC class II protein complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of T cell activation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of MHC class II protein complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
major histocompatibility complex B, class II beta chain DMB2; major histocompatibility complex, class II, DM beta 2
Names
B locus M beta chain 2
MHC class II M beta chain 2
MHC class II antigen
Major histocompatibility complex class II beta chain BMA2, (similar to HLA class II, D beta chain)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135166.2 → NP_001128638.1  major histocompatibility complex B, class II beta chain DMB2 precursor

    See identical proteins and their annotated locations for NP_001128638.1

    Status: PROVISIONAL

    Source sequence(s)
    JAENSK010000283
    UniProtKB/TrEMBL
    A5HUL8, B5BSA4
    Related
    ENSGALP00010005207.1, ENSGALT00010008863.1
    Conserved Domains (1) summary
    cd05766
    Location:111 → 205
    IgC_MHC_II_beta; Class II major histocompatibility complex (MHC) beta chain immunoglobulin domain

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052547.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    2209752..2212783
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015294967.4 → XP_015150453.1  major histocompatibility complex, class II, DM beta 2 isoform X2

    UniProtKB/TrEMBL
    A0A8V0XAR1, B5BSA4
    Related
    ENSGALP00010005204.1, ENSGALT00010008860.1
    Conserved Domains (1) summary
    cd05766
    Location:113 → 207
    IgC_MHC_II_beta; Class II major histocompatibility complex (MHC) beta chain immunoglobulin domain

  2. XM_015294966.3 → XP_015150452.2  major histocompatibility complex, class II, DM beta 2 isoform X1

    UniProtKB/TrEMBL
    F4ZCJ3
    Conserved Domains (1) summary
    smart00407
    Location:190 → 259
    IGc1; Immunoglobulin C-Type

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052588.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    1110880..1113912
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046928543.1 → XP_046784499.1  major histocompatibility complex, class II, DM beta 2 isoform X2

    UniProtKB/TrEMBL
    A0A8V0XAR1, B5BSA4

  2. XM_046928542.1 → XP_046784498.1  major histocompatibility complex, class II, DM beta 2 isoform X1

    UniProtKB/TrEMBL
    F4ZCJ3
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
T28147 GenPept UniProt:T28147

Gene LinkOut

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