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Ipp Inositol polyphosphate 1-phosphatase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41701, updated on 18-Sep-2024

Summary

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Official Symbol
Ippprovided by FlyBase
Official Full Name
Inositol polyphosphate 1-phosphataseprovided by FlyBase
Primary source
FLYBASE:FBgn0016672
Locus tag
Dmel_CG3028
See related
AllianceGenome:FB:FBgn0016672
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO02059370.48; CG3028; Dmel\CG3028; ipp; IPP; IPPase
Summary
Enables inositol-1,4-bisphosphate 1-phosphatase activity. Involved in chemical synaptic transmission and inositol phosphate dephosphorylation. Is expressed in several structures, including head and ring gland primordium. Orthologous to human INPP1 (inositol polyphosphate-1-phosphatase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See Ipp in Genome Data Viewer
Location:
88A3-88A3; 3-54 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (13958789..13960474)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (9784511..9786196)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Arginine methyltransferase 6 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Kotsubu Neighboring gene Origin recognition complex subunit 2 Neighboring gene roadkill

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The role of phosphatases in inositol signaling reactions. Majerus PW, et al. J Biol Chem, 1999 Apr 16. PMID 10196133
  2. A Drosophila homolog of the yeast origin recognition complex. Gossen M, et al. Science, 1995 Dec 8. PMID 7502079
  3. Synaptic defects and compensatory regulation of inositol metabolism in inositol polyphosphate 1-phosphatase mutants. Acharya JK, et al. Neuron, 1998 Jun. PMID 9655509
  4. Pharmacological and genetic reversal of age-dependent cognitive deficits attributable to decreased presenilin function. McBride SM, et al. J Neurosci, 2010 Jul 14. PMID 20631179, Free PMC Article
  5. Molecular Mechanisms of Lithium Action: Switching the Light on Multiple Targets for Dementia Using Animal Models. Kerr F, et al. Front Mol Neurosci, 2018. PMID 30210290, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables inositol-1,4-bisphosphate 1-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables inositol-1,4-bisphosphate 1-phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables inositol-1,4-bisphosphate 1-phosphatase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phosphatidylinositol phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
inositol polyphosphate 1-phosphatase
Names
CG3028-PA
Ipp-PA
NP_731872.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    13958789..13960474
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_169562.2 → NP_731872.1  inositol polyphosphate 1-phosphatase [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731872.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O76455, Q9VFP6
    Related
    FBpp0082328
    Conserved Domains (1) summary
    cd01640
    Location:10 → 371
    IPPase; IPPase; Inositol polyphosphate-1-phosphatase, a member of the Mg++ dependent family of inositol monophosphatase-like domains, hydrolyzes the 1' position phosphate from inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Members in this group may ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O76455 O76455
Q9VFP6 Q9VFP6

Gene LinkOut

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