PIWIL1 piwi like RNA-mediated gene silencing 1 [Gallus gallus (chicken)] - Gene

Summary

Symbol: PIWIL1provided by CGNC
Full Name: piwi like RNA-mediated gene silencing 1provided by CGNC
Primary source: CGNC:50348
See related: Ensembl:ENSGALG00010023240
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: CIWI; PIWI
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 15

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	15	NC_052546.1 (3355167..3373378, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	15	NC_052587.1 (3359766..3377709, complement)

Chromosome 15 - NC_052546.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Chicken PIWIL1 was detected continually in the developing germ cells at various developmental stages of male and female gonads. In the adult chickens, PIWIL1 was restricted to spermatogonia in males and oocytes in females.
Title: Small non-coding RNA profiling and the role of piRNA pathway genes in the protection of chicken primordial germ cells.
we show the negative correlation between promoter methylation and piwil1 expression and that the spatiotemporal expression of chicken Piwil1 from the PGC stage to the round spermatid stage is influenced by methylation-mediated transcription factor regulation.
Title: DNA methylation-mediated transcription factors regulate Piwil1 expression during chicken spermatogenesis.
Piwil1 plays a key role in meiosis during chicken spermatogenesis.
Title: Piwil1 mediates meiosis during spermatogenesis in chicken.
The screened SNPs can be used as candidate markers for Piwi, and our results provide basic information for the further study of Piwi function in poultry.
Title: Single nucleotide polymorphism screening, molecular characterization, and evolutionary aspects of chicken Piwi genes.
expression during spermatogenesis regulated by DNA methylation and NF-Y
Title: DNA methylation and NF-Y regulate Piwil1 expression during chicken spermatogenesis.
The Piwi-like 1 (Piwil1) gene was cloned and its expression was characterized in the Langshan chickens.
Title: Cloning and expression characterization of the chicken Piwil1 gene.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables piRNA binding	IEA Inferred from Electronic Annotation more info	PubMed
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in regulatory ncRNA-mediated gene silencing	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in P granule	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: piwi-like protein 1

Names: piwi-like 1

NP_001092322.1

EC 3.1.26.-

XP_046757079.1

EC 3.1.26.-

XP_046784068.1

EC 3.1.26.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001098852.2 → NP_001092322.1 piwi-like protein 1

See identical proteins and their annotated locations for NP_001092322.1

Status: VALIDATED

Source sequence(s)

JAENSK010000260

UniProtKB/Swiss-Prot

A6N7Y9

UniProtKB/TrEMBL

A0A8V0ZVE7

Related

ENSGALP00010034419.1, ENSGALT00010056677.1

Conserved Domains (3) summary

smart00949
Location:285 → 421

PAZ; This domain is named PAZ after the proteins Piwi Argonaut and Zwille

cd04658
Location:407 → 850

Piwi_piwi-like_Euk; Piwi_piwi-like_Euk: PIWI domain, Piwi-like subfamily found in eukaryotes. This domain is found in Piwi and closely related proteins, where it is believed to perform a crucial role in germline cells, via RNA silencing. RNA silencing refers to a group of ...

pfam05831
Location:22 → 114

GAGE; GAGE protein

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052546.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

3355167..3373378 complement

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GenBank, FASTA, Sequence Viewer (Graphics)