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PAK5 p21 (RAC1) activated kinase 5 [ Gallus gallus (chicken) ]

Gene ID: 416734, updated on 10-Oct-2024

Summary

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Symbol
PAK5provided by CGNC
Full Name
p21 (RAC1) activated kinase 5provided by CGNC
Primary source
CGNC:6796
See related
Ensembl:ENSGALG00010018367
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
PAK7
Orthologs
human mouse all
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Genomic context

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See PAK5 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
24
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 3 NC_052534.1 (13322621..13638915)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 3 NC_052575.1 (13232827..13549171)

Chromosome 3 - NC_052534.1Genomic Context describing neighboring genes Neighboring gene SLX4 interacting protein Neighboring gene uncharacterized LOC124417870 Neighboring gene jagged canonical Notch ligand 1 Neighboring gene MKKS centrosomal shuttling protein Neighboring gene synaptosome associated protein 25 Neighboring gene D-beta-hydroxybutyrate dehydrogenase, mitochondrial-like Neighboring gene ankyrin repeat and EF-hand domain containing 1 Neighboring gene uncharacterized LOC121110387 Neighboring gene lysosomal associated membrane protein family member 5 Neighboring gene phospholipase C beta 4 Neighboring gene uncharacterized LOC107052866 Neighboring gene phospholipase C beta 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of MAPK cascade IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
serine/threonine-protein kinase PAK 5
Names
p21 protein (Cdc42/Rac)-activated kinase 7
p21(CDKN1A)-activated kinase 7
serine/threonine-protein kinase PAK 7
NP_001385143.1
XP_040552881.2
XP_040552882.1
XP_040552883.1
XP_046769374.1
XP_046769375.1
XP_046769376.1
XP_046769377.1
XP_046769378.1
XP_046769379.1
XP_046769380.1
XP_046769381.1
XP_046769382.1
XP_046769383.1
XP_046769384.1
XP_046769385.1
XP_046769386.1
XP_046769387.1
XP_046769388.1
XP_046769389.1
XP_046794583.1
XP_046794584.1
XP_046794585.1
XP_046794586.1
XP_046794587.1
XP_046794588.1
XP_046794589.1
XP_046794590.1
XP_046794591.1
XP_046794592.1
XP_046794593.1
XP_046794595.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001398214.1 → NP_001385143.1  serine/threonine-protein kinase PAK 5

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000062
    UniProtKB/TrEMBL
    E1BWY7
    Conserved Domains (2) summary
    cd01093
    Location:56 → 102
    CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
    cl21453
    Location:477 → 768
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052534.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    13322621..13638915
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046938631.1 → XP_046794587.1  serine/threonine-protein kinase PAK 5 isoform X2

    UniProtKB/TrEMBL
    E1BWY7

  2. XM_046938634.1 → XP_046794590.1  serine/threonine-protein kinase PAK 5 isoform X2

    UniProtKB/TrEMBL
    E1BWY7

  3. XM_046938630.1 → XP_046794586.1  serine/threonine-protein kinase PAK 5 isoform X2

    UniProtKB/TrEMBL
    E1BWY7

  4. XM_046938633.1 → XP_046794589.1  serine/threonine-protein kinase PAK 5 isoform X2

    UniProtKB/TrEMBL
    E1BWY7

  5. XM_046938632.1 → XP_046794588.1  serine/threonine-protein kinase PAK 5 isoform X2

    UniProtKB/TrEMBL
    E1BWY7

  6. XM_046938628.1 → XP_046794584.1  serine/threonine-protein kinase PAK 5 isoform X2

    UniProtKB/TrEMBL
    E1BWY7

  7. XM_046938627.1 → XP_046794583.1  serine/threonine-protein kinase PAK 5 isoform X1

  8. XM_040696947.2 → XP_040552881.2  serine/threonine-protein kinase PAK 5 isoform X1

  9. XM_040696948.2 → XP_040552882.1  serine/threonine-protein kinase PAK 5 isoform X2

    UniProtKB/TrEMBL
    A0A8V0YZF2, E1BWY7
    Conserved Domains (2) summary
    cd01093
    Location:56 → 102
    CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
    cl21453
    Location:477 → 768
    PKc_like; Protein Kinases, catalytic domain

  10. XM_046938639.1 → XP_046794595.1  serine/threonine-protein kinase PAK 5 isoform X2

    UniProtKB/TrEMBL
    E1BWY7

  11. XM_046938629.1 → XP_046794585.1  serine/threonine-protein kinase PAK 5 isoform X2

    UniProtKB/TrEMBL
    E1BWY7
    Related
    ENSGALP00010026386.1, ENSGALT00010044345.1

  12. XM_046938635.1 → XP_046794591.1  serine/threonine-protein kinase PAK 5 isoform X2

    UniProtKB/TrEMBL
    E1BWY7

  13. XM_040696949.2 → XP_040552883.1  serine/threonine-protein kinase PAK 5 isoform X2

    UniProtKB/TrEMBL
    A0A8V0YZF2, E1BWY7
    Related
    ENSGALP00010026383.1, ENSGALT00010044340.1
    Conserved Domains (2) summary
    cd01093
    Location:56 → 102
    CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
    cl21453
    Location:477 → 768
    PKc_like; Protein Kinases, catalytic domain

  14. XM_046938636.1 → XP_046794592.1  serine/threonine-protein kinase PAK 5 isoform X2

    UniProtKB/TrEMBL
    E1BWY7

  15. XM_046938637.1 → XP_046794593.1  serine/threonine-protein kinase PAK 5 isoform X2

    UniProtKB/TrEMBL
    E1BWY7

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052575.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    13232827..13549171
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046913425.1 → XP_046769381.1  serine/threonine-protein kinase PAK 5 isoform X2

  2. XM_046913428.1 → XP_046769384.1  serine/threonine-protein kinase PAK 5 isoform X2

  3. XM_046913423.1 → XP_046769379.1  serine/threonine-protein kinase PAK 5 isoform X2

  4. XM_046913427.1 → XP_046769383.1  serine/threonine-protein kinase PAK 5 isoform X2

  5. XM_046913426.1 → XP_046769382.1  serine/threonine-protein kinase PAK 5 isoform X2

  6. XM_046913421.1 → XP_046769377.1  serine/threonine-protein kinase PAK 5 isoform X2

  7. XM_046913418.1 → XP_046769374.1  serine/threonine-protein kinase PAK 5 isoform X1

  8. XM_046913419.1 → XP_046769375.1  serine/threonine-protein kinase PAK 5 isoform X1

  9. XM_046913420.1 → XP_046769376.1  serine/threonine-protein kinase PAK 5 isoform X2

  10. XM_046913431.1 → XP_046769387.1  serine/threonine-protein kinase PAK 5 isoform X2

  11. XM_046913422.1 → XP_046769378.1  serine/threonine-protein kinase PAK 5 isoform X2

  12. XM_046913429.1 → XP_046769385.1  serine/threonine-protein kinase PAK 5 isoform X2

  13. XM_046913433.1 → XP_046769389.1  serine/threonine-protein kinase PAK 5 isoform X2

  14. XM_046913424.1 → XP_046769380.1  serine/threonine-protein kinase PAK 5 isoform X2

  15. XM_046913430.1 → XP_046769386.1  serine/threonine-protein kinase PAK 5 isoform X2

  16. XM_046913432.1 → XP_046769388.1  serine/threonine-protein kinase PAK 5 isoform X2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001199409.2: Suppressed sequence

    Description
    NM_001199409.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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