pigk phosphatidylinositol glycan anchor biosynthesis, class K [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pigkprovided by ZNC
Official Full Name: phosphatidylinositol glycan anchor biosynthesis, class Kprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040625-162
See related: Ensembl:ENSDARG00000024479 AllianceGenome:ZFIN:ZDB-GENE-040625-162
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:86702
Summary: Predicted to enable GPI-anchor transamidase activity. Acts upstream of or within detection of mechanical stimulus involved in sensory perception of touch and protein localization to cell surface. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be part of GPI-anchor transamidase complex. Orthologous to human PIGK (phosphatidylinositol glycan anchor biosynthesis class K). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (9061885..9138497)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (9263880..9340492)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results demonstrate an essential role for pigk in generation of the touch response beyond that required for maintenance of proper sodium current density and action potential firing in sensory neurons
Title: pigk Mutation underlies macho behavior and affects Rohon-Beard cell excitability.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables GPI-anchor transamidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GPI-anchor transamidase activity	IEA Inferred from Electronic Annotation more info
enables cysteine-type peptidase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within GPI anchor biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in attachment of GPI anchor to protein	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within attachment of GPI anchor to protein	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within detection of mechanical stimulus involved in sensory perception of touch	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein localization to cell surface	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of GPI-anchor transamidase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of GPI-anchor transamidase complex	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: GPI-anchor transamidase

Names: gpi8; maco; mao(l); phosphatidylinositol glycan, class K

NP_001002149.1

EC 3.-.-.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001002149.1 → NP_001002149.1 GPI-anchor transamidase precursor

See identical proteins and their annotated locations for NP_001002149.1

Status: PROVISIONAL

Source sequence(s)

BC071379

UniProtKB/TrEMBL

A0A8M1N054, Q6IQM5

Related

ENSDARP00000039104.8, ENSDART00000028906.9

Conserved Domains (1) summary

cl00042
Location:36 → 386

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...