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MITF melanocyte inducing transcription factor [ Canis lupus familiaris (dog) ]

Gene ID: 415126, updated on 17-Aug-2024

Summary

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Official Symbol
MITFprovided by VGNC
Official Full Name
melanocyte inducing transcription factorprovided by VGNC
Primary source
VGNC:VGNC:43248
See related
Ensembl:ENSCAFG00845009666
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
MITF-H; MITF-M
Orthologs
human mouse all
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Genomic context

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See MITF in Genome Data Viewer
Location:
chromosome: 20
Exon count:
13
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 20 NC_051824.1 (21883312..22101930, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 20 NC_006602.4 (21826585..21857697, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 20 NC_049241.1 (21991588..22022704, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 20 NC_049280.1 (21572611..21603715, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 20 NC_049761.1 (21921161..21952266, complement)

Chromosome 20 - NC_051824.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC119864576 Neighboring gene uncharacterized LOC102155999 Neighboring gene uncharacterized LOC119864577 Neighboring gene uncharacterized LOC119864578

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sequence variants of the canine melanocyte inducing transcription factor (MITF) locus reveal a common MITF-A processed pseudogene. Brancalion L, et al. Anim Genet, 2021 Oct. PMID 34165209
  2. TGF-β Negatively Regulates Mitf-E Expression and Canine Osteoclastogenesis. Asai K, et al. Biochem Genet, 2018 Oct. PMID 29680988
  3. A role of the microphthalmia-associated transcription factor in congenital sensorineural deafness and eye pigmentation in Dalmatian dogs. Stritzel S, et al. J Anim Breed Genet, 2009 Feb. PMID 19207931
  4. Association of MITF with white spotting in Beagle crosses and Newfoundland dogs. Rothschild MF, et al. Anim Genet, 2006 Dec. PMID 17121617
  5. Genomic Regions Associated with Variation in Pigmentation Loss in Saddle Tan Beagles. Nord ME, et al. Genes (Basel), 2021 Feb 23. PMID 33672409, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Sequence variants of the canine melanocyte inducing transcription factor (MITF) locus reveal a common MITF-A processed pseudogene.
    Title: Sequence variants of the canine melanocyte inducing transcription factor (MITF) locus reveal a common MITF-A processed pseudogene.
  2. Genomic Regions Associated with Variation in Pigmentation Loss in Saddle Tan Beagles.
    Title: Genomic Regions Associated with Variation in Pigmentation Loss in Saddle Tan Beagles.
  3. Results show that Mitf-E but not Mitf-A isoform expression is induced during osteoclastogenesis.
    Title: TGF-β Negatively Regulates Mitf-E Expression and Canine Osteoclastogenesis.
  4. MITF might play a role in congenital sensorineural deafness and blue eye colour in Dalmatian dogs.
    Title: A role of the microphthalmia-associated transcription factor in congenital sensorineural deafness and eye pigmentation in Dalmatian dogs.
  5. MITF on dog chromosome 20 shows association with white spotting (inherited recessively) in Beagle and Newfoundland dogs.
    Title: Association of MITF with white spotting in Beagle crosses and Newfoundland dogs.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in melanocyte differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
microphthalmia-associated transcription factor
Names
melanogenesis associated transcription factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003337.1 → NP_001003337.1  microphthalmia-associated transcription factor

    See identical proteins and their annotated locations for NP_001003337.1

    Status: PROVISIONAL

    Source sequence(s)
    AY240952
    UniProtKB/TrEMBL
    A0A8C0YSP0, F1PY12, Q6UUT7, Q864F3
    Related
    ENSCAFP00845013465.1, ENSCAFT00845017276.1
    Conserved Domains (3) summary
    cd00083
    Location:202 → 262
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    pfam11851
    Location:290 → 403
    DUF3371; Domain of unknown function (DUF3371)
    pfam15951
    Location:11 → 87
    MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051824.1 Reference ROS_Cfam_1.0

    Range
    21883312..22101930 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038426380.1 → XP_038282308.1  microphthalmia-associated transcription factor isoform X4

    UniProtKB/TrEMBL
    A0A8C0S2P6, A0A8P0PS65
    Conserved Domains (3) summary
    cd18926
    Location:293 → 396
    bHLHzip_MITF; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins
    pfam11851
    Location:390 → 509
    DUF3371; Domain of unknown function (DUF3371)
    pfam15951
    Location:55 → 193
    MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

  2. XM_038426378.1 → XP_038282306.1  microphthalmia-associated transcription factor isoform X2

    UniProtKB/TrEMBL
    A0A8C0S2P6, A0A8P0PS65
    Conserved Domains (3) summary
    cd18926
    Location:299 → 402
    bHLHzip_MITF; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins
    pfam11851
    Location:396 → 515
    DUF3371; Domain of unknown function (DUF3371)
    pfam15951
    Location:55 → 193
    MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

  3. XM_038426385.1 → XP_038282313.1  microphthalmia-associated transcription factor isoform X9

    UniProtKB/TrEMBL
    A0A8I3NE18, A0A8P0NY70
    Related
    ENSCAFP00845013398.1, ENSCAFT00845017193.1
    Conserved Domains (3) summary
    cd18926
    Location:224 → 327
    bHLHzip_MITF; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins
    pfam11851
    Location:321 → 440
    DUF3371; Domain of unknown function (DUF3371)
    pfam15951
    Location:56 → 118
    MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

  4. XM_038426379.1 → XP_038282307.1  microphthalmia-associated transcription factor isoform X3

    UniProtKB/TrEMBL
    A0A8C0KDQ1, A0A8C0S2P6, A0A8I3N265, A0A8P0PS65
    Related
    ENSCAFP00845013351.1, ENSCAFT00845017138.1
    Conserved Domains (3) summary
    cd18926
    Location:294 → 397
    bHLHzip_MITF; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins
    pfam11851
    Location:391 → 510
    DUF3371; Domain of unknown function (DUF3371)
    pfam15951
    Location:56 → 194
    MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

  5. XM_038426377.1 → XP_038282305.1  microphthalmia-associated transcription factor isoform X1

    UniProtKB/TrEMBL
    A0A8C0MLN0, A0A8C0S2P6, A0A8P0PS65, A0A8P0SRD5
    Conserved Domains (3) summary
    cd18926
    Location:300 → 403
    bHLHzip_MITF; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins
    pfam11851
    Location:397 → 516
    DUF3371; Domain of unknown function (DUF3371)
    pfam15951
    Location:56 → 194
    MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

  6. XM_038426384.1 → XP_038282312.1  microphthalmia-associated transcription factor isoform X8

    UniProtKB/TrEMBL
    A0A8C0S2Z1
    Conserved Domains (3) summary
    cd18926
    Location:268 → 371
    bHLHzip_MITF; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins
    pfam11851
    Location:365 → 484
    DUF3371; Domain of unknown function (DUF3371)
    pfam15951
    Location:24 → 162
    MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

  7. XM_038426383.1 → XP_038282311.1  microphthalmia-associated transcription factor isoform X7

    UniProtKB/TrEMBL
    A0A8C0S2Z1
    Conserved Domains (3) summary
    cd18926
    Location:278 → 381
    bHLHzip_MITF; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins
    pfam11851
    Location:375 → 494
    DUF3371; Domain of unknown function (DUF3371)
    pfam15951
    Location:40 → 178
    MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

  8. XM_038426381.1 → XP_038282309.1  microphthalmia-associated transcription factor isoform X5

    UniProtKB/TrEMBL
    A0A8C0MRU3, A0A8C0S2Z1, A0A8I3ND12
    Related
    ENSCAFP00845013307.1, ENSCAFT00845017088.1
    Conserved Domains (3) summary
    cd18926
    Location:284 → 387
    bHLHzip_MITF; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins
    pfam11851
    Location:381 → 500
    DUF3371; Domain of unknown function (DUF3371)
    pfam15951
    Location:40 → 178
    MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

  9. XM_038426382.1 → XP_038282310.1  microphthalmia-associated transcription factor isoform X6

    UniProtKB/TrEMBL
    A0A8C0S2Z1
    Conserved Domains (3) summary
    cd18926
    Location:283 → 386
    bHLHzip_MITF; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins
    pfam11851
    Location:380 → 499
    DUF3371; Domain of unknown function (DUF3371)
    pfam15951
    Location:39 → 177
    MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

  10. XM_038426386.1 → XP_038282314.1  microphthalmia-associated transcription factor isoform X10

    UniProtKB/TrEMBL
    Q6UUT7
    Conserved Domains (3) summary
    cd18926
    Location:187 → 290
    bHLHzip_MITF; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins
    pfam11851
    Location:284 → 403
    DUF3371; Domain of unknown function (DUF3371)
    pfam15951
    Location:11 → 87
    MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049280.1 Alternate UMICH_Zoey_3.1

    Range
    21572611..21603715 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049761.1 Alternate UNSW_CanFamBas_1.0

    Range
    21921161..21952266 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049241.1 Alternate UU_Cfam_GSD_1.0

    Range
    21991588..22022704 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006602.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    21826585..21857697 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
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