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prd1 pruning defect 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41425, updated on 18-Sep-2024

Summary

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Official Symbol
prd1provided by FlyBase
Official Full Name
pruning defect 1provided by FlyBase
Primary source
FLYBASE:FBgn0037949
Locus tag
Dmel_CG17360
See related
AllianceGenome:FB:FBgn0037949
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:RH29885; CG17360; Dmel\CG17360
Summary
Enables small GTPase binding activity. Predicted to be involved in several processes, including Golgi organization; lysosome localization; and positive regulation of membrane tubulation. Located in Golgi apparatus. Orthologous to human PLEKHM2 (pleckstrin homology and RUN domain containing M2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See prd1 in Genome Data Viewer
Location:
86E18-86F7; 3-51 cM
Exon count:
11
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (11781131..11787014, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (7606853..7612736, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene lethal (3) neo38 Neighboring gene long non-coding RNA:CR45595 Neighboring gene Histamine-gated chloride channel subunit 1 Neighboring gene SET domain binding factor Neighboring gene Chloride channel-a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Prd1 associates with the clathrin adaptor α-Adaptin and the kinesin-3 Imac/Unc-104 to govern dendrite pruning in Drosophila. Zong W, et al. PLoS Biol, 2018 Aug. PMID 30142146, Free PMC Article
  2. The Neurexin/N-Ethylmaleimide-sensitive Factor (NSF) Interaction Regulates Short Term Synaptic Depression. Li T, et al. J Biol Chem, 2015 Jul 17. PMID 25953899, Free PMC Article
  3. Toward a comprehensive map of the effectors of rab GTPases. Gillingham AK, et al. Dev Cell, 2014 Nov 10. PMID 25453831, Free PMC Article
  4. Genes conserved in bilaterians but jointly lost with Myc during nematode evolution are enriched in cell proliferation and cell migration functions. Erives AJ. Dev Genes Evol, 2015 Sep. PMID 26173873, Free PMC Article
  5. Genome-wide phenotypic RNAi screen in the Drosophila wing: phenotypic description of functional classes. López-Varea A, et al. G3 (Bethesda), 2021 Dec 8. PMID 34599810, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Prd1, alpha-Adaptin, and Unc-104 act in a common pathway to promote dendrite pruning by down-regulating Neuroglian protein.
    Title: Prd1 associates with the clathrin adaptor α-Adaptin and the kinesin-3 Imac/Unc-104 to govern dendrite pruning in Drosophila.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables kinesin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Golgi organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lysosome localization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of protein localization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
pruning defect 1
Names
CG17360-PA
CG17360-PB
prd1-PA
prd1-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    11781131..11787014 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_141858.2 → NP_650115.1  pruning defect 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650115.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6NR50, Q9VGI1
    Related
    FBpp0082005
    Conserved Domains (2) summary
    cd13309
    Location:1022 → 1126
    PH_SKIP; SifA and kinesin-interacting protein Pleckstrin homology (PH) domain
    pfam00169
    Location:1021 → 1119
    PH; PH domain

  2. NM_001275557.1 → NP_001262486.1  pruning defect 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262486.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KH60, Q6NR50
    Conserved Domains (2) summary
    cd13309
    Location:998 → 1102
    PH_SKIP; SifA and kinesin-interacting protein Pleckstrin homology (PH) domain
    pfam00169
    Location:997 → 1095
    PH; PH domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KH60 A0A0B4KH60
Q6NR50 Q6NR50
Q8IGG0 Q8IGG0
Q9VGI1 Q9VGI1

Gene LinkOut

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