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Csk C-terminal Src kinase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41398, updated on 22-Aug-2024

Summary

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Official Symbol
Cskprovided by FlyBase
Official Full Name
C-terminal Src kinaseprovided by FlyBase
Primary source
FLYBASE:FBgn0262081
Locus tag
Dmel_CG42317
See related
AllianceGenome:FB:FBgn0262081
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG17309; CG32852; CG42317; csk; CSK; d-Csk; dcsk; dCsk; dCSK; DCsk; Dmel\CG42317; flik; l(3)j1D8; l(3)S017909; Src
Old locus tag
Dmel_CG17309; Dmel_CG32852
Summary
Enables non-membrane spanning protein tyrosine kinase activity. Involved in several processes, including adherens junction maintenance; negative regulation of imaginal disc growth; and positive regulation of hippo signaling. Predicted to be located in cell-cell junction. Is expressed in salivary gland. Orthologous to several human genes including CSK (C-terminal Src kinase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
86E13-86E13; 3-51 cM
Exon count:
12
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (11633278..11650706, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (7459000..7476428, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44137 Neighboring gene Elongator complex protein 1 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. C-terminal Src kinase (Csk) regulates the tricellular junction protein Gliotactin independent of Src. Samarasekera GDNG, et al. Mol Biol Cell, 2018 Jan 15. PMID 29167383, Free PMC Article
  2. A genetic screen for modifiers of the lats tumor suppressor gene identifies C-terminal Src kinase as a regulator of cell proliferation in Drosophila. Stewart RA, et al. Oncogene, 2003 Sep 25. PMID 14508523
  3. Interactions between normal and transformed epithelial cells: Their contributions to tumourigenesis. Hogan C, et al. Int J Biochem Cell Biol, 2011 Apr. PMID 21187160
  4. A role for the epithelial microenvironment at tumor boundaries: evidence from Drosophila and human squamous cell carcinomas. Vidal M, et al. Am J Pathol, 2010 Jun. PMID 20363916, Free PMC Article
  5. Drosophila Src-family kinases function with Csk to regulate cell proliferation and apoptosis. Pedraza LG, et al. Oncogene, 2004 Jun 10. PMID 15107833

See all (97) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. C-terminal Src kinase (Csk) as a tyrosine kinase is responsible for regulating Gliotactin endocytosis. Increased Csk suppresses the Gliotactin overexpression phenotypes by increasing endocytosis. Loss of Csk causes Gliotactin to spread away from the Tricellular junctions.
    Title: C-terminal Src kinase (Csk) regulates the tricellular junction protein Gliotactin independent of Src.
  2. Csk and its SFK substrates impinge upon homeostatic control of NMJ function by regulating downstream expression or localization of FasII.
    Title: C-terminal Src Kinase Gates Homeostatic Synaptic Plasticity and Regulates Fasciclin II Expression at the Drosophila Neuromuscular Junction.
  3. dCsk is another upstream member of the network of genes that interact to regulate Wts and its effector Yki in the Hippo signaling pathway
    Title: Drosophila C-terminal Src kinase regulates growth via the Hippo signaling pathway.
  4. A functional link between cell polarity, the JAK/STAT signalling pathway and the Src kinases has been established in a whole organism.
    Title: Src kinases mediate the interaction of the apical determinant Bazooka/PAR3 with STAT92E and increase signalling efficiency in Drosophila ectodermal cells.
  5. Drosophila Src-family kinases function with Csk to regulate cell proliferation and apoptosis.
    Title: Drosophila Src-family kinases function with Csk to regulate cell proliferation and apoptosis.
  6. Drosophila C-terminal Src kinase negatively regulates organ growth and cell proliferation through inhibition of the Src, Jun N-terminal kinase, and STAT pathways
    Title: Drosophila C-terminal Src kinase negatively regulates organ growth and cell proliferation through inhibition of the Src, Jun N-terminal kinase, and STAT pathways.
  7. Results demonstrate that regulation of Src64 by Drosophila C-terminal-Src Kinase (Csk) contributes to the packaging of germline cysts by overlying somatic follicle cells during egg chamber formation.
    Title: Csk differentially regulates Src64 during distinct morphological events in Drosophila germ cells.
  8. C-terminal Src kinase (CSK) in Drosophila was identified in a genetic modifier screen for genes that interact with the lats tumor suppressor gene. CSK regulates cell proliferation and organ size.
    Title: A genetic screen for modifiers of the lats tumor suppressor gene identifies C-terminal Src kinase as a regulator of cell proliferation in Drosophila.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables non-membrane spanning protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in adherens junction maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell migration IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in epithelial structure maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment or maintenance of epithelial cell apical/basal polarity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in germarium-derived egg chamber formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of growth IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of imaginal disc growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of hippo signaling IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of programmed cell death IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of synaptic plasticity IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cell-cell junction ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
C-terminal Src kinase
Names
C-Src kinase
C-terminal-Src kinase
CG42317-PF
CG42317-PG
CG42317-PH
CG42317-PI
CG42317-PJ
CG42317-PK
CG42317-PL
Csk-PF
Csk-PG
Csk-PH
Csk-PI
Csk-PJ
Csk-PK
Csk-PL
drosophila C-terminal Src kinase
flik
lethal (3) S017909
lethal (3) j1D8
NP_001262476.1
NP_650097.2
NP_731607.1
NP_731608.1
NP_731609.1
NP_731611.2
NP_788638.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    11633278..11650706 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_169414.2 → NP_731607.1  C-terminal Src kinase, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731607.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6NP28, Q7KSQ2
    Related
    FBpp0289774
    Conserved Domains (3) summary
    cd09937
    Location:351 → 448
    SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
    smart00221
    Location:471 → 715
    STYKc; Protein kinase; unclassified specificity
    cd05039
    Location:464 → 718
    PTKc_Csk_like; Catalytic domain of C-terminal Src kinase-like Protein Tyrosine Kinases

  2. NM_169418.3 → NP_731611.2  C-terminal Src kinase, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731611.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8INJ8
    Conserved Domains (3) summary
    cd09937
    Location:680 → 777
    SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
    smart00221
    Location:800 → 1044
    STYKc; Protein kinase; unclassified specificity
    cd05039
    Location:793 → 1047
    PTKc_Csk_like; Catalytic domain of C-terminal Src kinase-like Protein Tyrosine Kinases

  3. NM_141840.1 → NP_650097.2  C-terminal Src kinase, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650097.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6NP28, Q9VGK8, Q9VGK9
    Related
    FBpp0289773, FBtr0300546
    Conserved Domains (3) summary
    cd09937
    Location:433 → 530
    SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
    smart00221
    Location:553 → 797
    STYKc; Protein kinase; unclassified specificity
    cd05039
    Location:546 → 800
    PTKc_Csk_like; Catalytic domain of C-terminal Src kinase-like Protein Tyrosine Kinases

  4. NM_001275547.1 → NP_001262476.1  C-terminal Src kinase, isoform L [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262476.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8INJ8
    Conserved Domains (3) summary
    cd09937
    Location:680 → 777
    SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
    smart00221
    Location:800 → 1044
    STYKc; Protein kinase; unclassified specificity
    cd05039
    Location:793 → 1047
    PTKc_Csk_like; Catalytic domain of C-terminal Src kinase-like Protein Tyrosine Kinases

  5. NM_176461.1 → NP_788638.1  C-terminal Src kinase, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788638.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6NP28, Q7KSQ2
    Related
    FBpp0289006, FBtr0299728
    Conserved Domains (3) summary
    cd09937
    Location:351 → 448
    SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
    smart00221
    Location:471 → 715
    STYKc; Protein kinase; unclassified specificity
    cd05039
    Location:464 → 718
    PTKc_Csk_like; Catalytic domain of C-terminal Src kinase-like Protein Tyrosine Kinases

  6. NM_169415.2 → NP_731608.1  C-terminal Src kinase, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731608.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6NP28, Q7KSQ2
    Related
    FBpp0289775, FBtr0300548
    Conserved Domains (3) summary
    cd09937
    Location:351 → 448
    SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
    smart00221
    Location:471 → 715
    STYKc; Protein kinase; unclassified specificity
    cd05039
    Location:464 → 718
    PTKc_Csk_like; Catalytic domain of C-terminal Src kinase-like Protein Tyrosine Kinases

  7. NM_169416.2 → NP_731609.1  C-terminal Src kinase, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731609.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6NP28, Q7KSQ2
    Related
    FBpp0289776, FBtr0300549
    Conserved Domains (3) summary
    cd09937
    Location:351 → 448
    SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
    smart00221
    Location:471 → 715
    STYKc; Protein kinase; unclassified specificity
    cd05039
    Location:464 → 718
    PTKc_Csk_like; Catalytic domain of C-terminal Src kinase-like Protein Tyrosine Kinases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7KSQ2 Q7KSQ2
Q8INJ8 Q8INJ8
Q9VGK8 Q9VGK8

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