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MAP2 microtubule associated protein 2 [ Homo sapiens (human) ]

Gene ID: 4133, updated on 7-Apr-2024

Summary

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Official Symbol
MAP2provided by HGNC
Official Full Name
microtubule associated protein 2provided by HGNC
Primary source
HGNC:HGNC:6839
See related
Ensembl:ENSG00000078018 MIM:157130; AllianceGenome:HGNC:6839
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MAP-2; MAP2A; MAP2B; MAP2C
Summary
This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dentrites, implicating a role in determining and stabilizing dentritic shape during neuron development. A number of alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq, Jan 2010]
Expression
Biased expression in brain (RPKM 82.4), thyroid (RPKM 4.7) and 1 other tissue See more
Orthologs
mouse all
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Genomic context

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See MAP2 in Genome Data Viewer
Location:
2q34
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (209424047..209734112)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (209904237..210214222)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (210288771..210598836)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene MYST/Esa1-associated factor 6 pseudogene 1 Neighboring gene plakophilin 4 pseudogene 1 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:210163633-210164292 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:210164293-210164952 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:210168954-210169953 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:210169954-210170952 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:210233444-210234643 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12291 Neighboring gene NANOG hESC enhancer GRCh37_chr2:210315845-210316346 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:210359703-210360902 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:210383815-210384500 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:210479322-210479919 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:210479920-210480516 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:210616149-210616706 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:210616707-210617263 Neighboring gene RNA, 5S ribosomal pseudogene 118 Neighboring gene NANOG hESC enhancer GRCh37_chr2:210638115-210638616 Neighboring gene Sharpr-MPRA regulatory region 8450 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr2:210729225-210729762 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr2:210729763-210730300 Neighboring gene unc-80 homolog, NALCN channel complex subunit Neighboring gene Sharpr-MPRA regulatory region 8902 Neighboring gene snail family zinc finger 1 pseudogene 1 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:210782411-210783610 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17053 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17054 Neighboring gene KAT8 regulatory NSL complex subunit 1 like Neighboring gene ribulose-5-phosphate-3-epimerase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Specific phosphorylation of microtubule-associated protein 2c by extracellular signal-regulated kinase reduces interactions at its Pro-rich regions. Plucarová J, et al. J Biol Chem, 2022 Oct. PMID 35987383, Free PMC Article
  2. Circ_001680 aggravates the malignant process of gastric carcinoma by targeting MAP2. Zhao HD, et al. Eur Rev Med Pharmacol Sci, 2020 Jun. PMID 32572922
  3. Microtubule-associated protein 2 knockdown sensitizes glioma cells to vincristine treatment. Yang L, et al. Neuroreport, 2020 Feb 5. PMID 31834144
  4. Functionally specific binding regions of microtubule-associated protein 2c exhibit distinct conformations and dynamics. Melková K, et al. J Biol Chem, 2018 Aug 24. PMID 29925592, Free PMC Article
  5. Temporal Profile of Microtubule-Associated Protein 2: A Novel Indicator of Diffuse Brain Injury Severity and Early Mortality after Brain Trauma. Papa L, et al. J Neurotrauma, 2018 Jan 1. PMID 28895474, Free PMC Article

See all (144) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Differential regulation of MAP2 by phosphorylation events in proline-rich versus C-terminal domains.
    Title: Differential regulation of MAP2 by phosphorylation events in proline-rich versus C-terminal domains.
  2. MAP2 caps tau fibrils and inhibits aggregation.
    Title: MAP2 caps tau fibrils and inhibits aggregation.
  3. Effects of three microtubule-associated proteins (MAP2, MAP4, and Tau) on microtubules' physical properties and neurite morphology.
    Title: Effects of three microtubule-associated proteins (MAP2, MAP4, and Tau) on microtubules' physical properties and neurite morphology.
  4. Specific phosphorylation of microtubule-associated protein 2c by extracellular signal-regulated kinase reduces interactions at its Pro-rich regions.
    Title: Specific phosphorylation of microtubule-associated protein 2c by extracellular signal-regulated kinase reduces interactions at its Pro-rich regions.
  5. Predicting Clinical Outcomes 7-10 Years after Severe Traumatic Brain Injury: Exploring the Prognostic Utility of the IMPACT Lab Model and Cerebrospinal Fluid UCH-L1 and MAP-2.
    Title: Predicting Clinical Outcomes 7-10 Years after Severe Traumatic Brain Injury: Exploring the Prognostic Utility of the IMPACT Lab Model and Cerebrospinal Fluid UCH-L1 and MAP-2.
  6. Methyltransferase-like (METTL)14-mediated N6-methyladenosine modification modulates retinal pigment epithelial (RPE) activity by regulating the methylation of microtubule-associated protein (MAP)2.
    Title: Methyltransferase-like (METTL)14-mediated N6-methyladenosine modification modulates retinal pigment epithelial (RPE) activity by regulating the methylation of microtubule-associated protein (MAP)2.
  7. Angiotensin II Induces Differentiation of Human Neuroblastoma Cells by Increasing MAP2 and ROS Levels.
    Title: Angiotensin II Induces Differentiation of Human Neuroblastoma Cells by Increasing MAP2 and ROS Levels.
  8. The Cytoskeletal Elements MAP2 and NF-L Show Substantial Alterations in Different Stroke Models While Elevated Serum Levels Highlight Especially MAP2 as a Sensitive Biomarker in Stroke Patients.
    Title: The Cytoskeletal Elements MAP2 and NF-L Show Substantial Alterations in Different Stroke Models While Elevated Serum Levels Highlight Especially MAP2 as a Sensitive Biomarker in Stroke Patients.
  9. Circ_001680 aggravates the malignant process of gastric carcinoma by targeting MAP2.
    Title: Circ_001680 aggravates the malignant process of gastric carcinoma by targeting MAP2.
  10. Microtubule alterations may destabilize photoreceptor integrity: Age-related microtubule changes and pattern of expression of MAP-2, Tau and hyperphosphorylated Tau in aging human photoreceptor cells.
    Title: Microtubule alterations may destabilize photoreceptor integrity: Age-related microtubule changes and pattern of expression of MAP-2, Tau and hyperphosphorylated Tau in aging human photoreceptor cells.
Submit: New GeneRIF Correction See all GeneRIFs (66)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120/MBL complex co-localizes with MAP2 and is transported along the microtubules in human primary neurons PubMed
env Ascorbate supplementation prevents the deleterious upregulation of iNOS and associated neuronal (MAP2) and astrocytic (GFAP) protein expression and structural changes caused by gp120 in human brain cell cultures PubMed
Tat tat HIV-1 Tat co-localizes with microtubule-associated protein 2 in neuronal cells PubMed
tat HIV-1 Tat downregulates expression of MAP2 in human microglia and neuroblastoma cells PubMed
retropepsin gag-pol HIV-1 protease extensively cleaves microtubule-associated proteins 1 and 2 and completely inhibits microtubule assembly PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp686I2148

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
enables dystroglycan binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural molecule activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables tau protein binding NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in central nervous system neuron development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in dendrite development TAS
Traceable Author Statement
more info
 PubMed 
involved_in dendrite morphogenesis IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of axon extension ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of microtubule binding ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of microtubule polymerization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in neuron projection development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuron projection development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in positive regulation of anterograde dense core granule transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of anterograde synaptic vesicle transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of microtubule polymerization TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of organelle transport along microtubule ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of protein localization ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in apical distal dendrite ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in axon hillock ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in axon initial segment ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in basal dendrite ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in dendrite ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in dendrite cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in dendritic branch ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in dendritic filopodium ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in dendritic growth cone ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in dendritic shaft ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in distal dendrite ISS
Inferred from Sequence or Structural Similarity
more info
  
NOT located_in main axon ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
part_of microtubule associated complex TAS
Traceable Author Statement
more info
 PubMed 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in neuron projection ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in neuronal cell body ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in primary dendrite ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in proximal dendrite ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in proximal neuron projection ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
microtubule-associated protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052836.1 RefSeqGene

    Range
    5001..315066
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001039538.2 → NP_001034627.1  microtubule-associated protein 2 isoform 5

    See identical proteins and their annotated locations for NP_001034627.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and includes an alternate in-frame exon, compared to variant 2, resulting in a longer protein (isoform 5), compared to isoform 2.
    Source sequence(s)
    AC006385, AC019106, AC079833, AC108072
    Consensus CDS
    CCDS33369.1
    UniProtKB/TrEMBL
    Q59FX9
    Related
    ENSP00000199940.6, ENST00000199940.10
    Conserved Domains (2) summary
    PTZ00449
    Location:175 → 389
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam00418
    Location:393 → 422
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

  2. NM_001363910.2 → NP_001350839.1  microtubule-associated protein 2 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in 5' UTR and includes three alternate in-frame exons compared to variant 2. It encodes a longer protein (isoform 6) compared to isoform 2. Variants 6 and 7 encode the same isoform (6).
    Source sequence(s)
    AC006385, AC019106, AC079833, AC108072
    Consensus CDS
    CCDS86916.1
    UniProtKB/TrEMBL
    A0A669KB77
    Conserved Domains (3) summary
    PTZ00449
    Location:1444 → 1684
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam00418
    Location:1688 → 1717
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    pfam08377
    Location:373 → 1501
    MAP2_projctn; MAP2/Tau projection domain

  3. NM_001363911.2 → NP_001350840.1  microtubule-associated protein 2 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) includes three alternate in-frame exons compared to variant 2. It encodes a longer protein (isoform 6) compared to isoform 2. Variants 6 and 7 encode the same isoform (6).
    Source sequence(s)
    AC006385, AC079833, AC108072
    Consensus CDS
    CCDS86916.1
    UniProtKB/TrEMBL
    A0A669KB77
    Conserved Domains (3) summary
    PTZ00449
    Location:1444 → 1684
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam00418
    Location:1688 → 1717
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    pfam08377
    Location:373 → 1501
    MAP2_projctn; MAP2/Tau projection domain

  4. NM_001363913.2 → NP_001350842.1  microtubule-associated protein 2 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 2. Variants 2, 8, 11, and 60 all encode the same isoform (2).
    Source sequence(s)
    AC006385, AC079833, AC108072
    Consensus CDS
    CCDS2385.1
    UniProtKB/TrEMBL
    A8K5Y1, Q59FX9
    Related
    ENSP00000376032.1, ENST00000392194.5
    Conserved Domains (1) summary
    pfam00418
    Location:367 → 398
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

  5. NM_001375474.1 → NP_001362403.1  microtubule-associated protein 2 isoform 24

    Status: REVIEWED

    Source sequence(s)
    AC006385, AC019106, AC079833, AC108072
    UniProtKB/TrEMBL
    Q59FX9
    Conserved Domains (2) summary
    PTZ00449
    Location:175 → 389
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam00418
    Location:393 → 422
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

  6. NM_001375493.1 → NP_001362422.1  microtubule-associated protein 2 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11), as well as variants 2, 8, and 60, encodes isoform 2.
    Source sequence(s)
    AC006385, AC019106, AC079833, AC108072
    Consensus CDS
    CCDS2385.1
    UniProtKB/TrEMBL
    A8K5Y1, Q59FX9
    Conserved Domains (1) summary
    pfam00418
    Location:367 → 398
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

  7. NM_001375494.1 → NP_001362423.1  microtubule-associated protein 2 isoform 30

    Status: REVIEWED

    Source sequence(s)
    AC006385, AC019106, AC079833, AC108072
    Conserved Domains (1) summary
    pfam00418
    Location:304 → 334
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

  8. NM_001375495.1 → NP_001362424.1  microtubule-associated protein 2 isoform 20

    Status: REVIEWED

    Description
    Transcript Variant: This variant (42), as well as variants 43 and 44, encodes isoform 20.
    Source sequence(s)
    AC006385, AC019106, AC079833, AC108072
    UniProtKB/TrEMBL
    Q59FX9
    Conserved Domains (3) summary
    PTZ00449
    Location:206 → 446
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam00418
    Location:450 → 479
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    pfam08377
    Location:151 → 263
    MAP2_projctn; MAP2/Tau projection domain

  9. NM_001375496.1 → NP_001362425.1  microtubule-associated protein 2 isoform 25

    Status: REVIEWED

    Source sequence(s)
    AC006385, AC019106, AC079833, AC108072
    UniProtKB/TrEMBL
    Q59FX9
    Conserved Domains (2) summary
    PTZ00449
    Location:174 → 388
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam00418
    Location:392 → 421
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

  10. NM_001375497.1 → NP_001362426.1  microtubule-associated protein 2 isoform 27

    Status: REVIEWED

    Description
    Transcript Variant: This variant (55), as well as variants 51 and 54, encodes isoform 27.
    Source sequence(s)
    AC006385, AC019106, AC079833, AC108072
    UniProtKB/TrEMBL
    A8K5Y1, Q59FX9
    Conserved Domains (1) summary
    pfam00418
    Location:335 → 364
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

  11. NM_001375498.1 → NP_001362427.1  microtubule-associated protein 2 isoform 19

    Status: REVIEWED

    Source sequence(s)
    AC006385, AC019106, AC079833, AC108072
    UniProtKB/TrEMBL
    Q59FX9
    Conserved Domains (3) summary
    PTZ00449
    Location:149 → 444
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam00418
    Location:448 → 477
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    pfam08377
    Location:150 → 262
    MAP2_projctn; MAP2/Tau projection domain

  12. NM_001375499.1 → NP_001362428.1  microtubule-associated protein 2 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14), as well as variants 4 and 15, encodes isoform 4.
    Source sequence(s)
    AC006385, AC019106, AC079833, AC108072
    UniProtKB/TrEMBL
    Q59FX9
    Conserved Domains (2) summary
    PHA03247
    Location:176 → 306
    PHA03247; large tegument protein UL36; Provisional
    pfam00418
    Location:336 → 365
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

  13. NM_001375500.1 → NP_001362429.1  microtubule-associated protein 2 isoform 18

    Status: REVIEWED

    Source sequence(s)
    AC006385, AC019106, AC079833, AC108072
    UniProtKB/TrEMBL
    A0A669KB77
    Conserved Domains (3) summary
    PTZ00449
    Location:1444 → 1684
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam00418
    Location:1660 → 1686
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    pfam08377
    Location:373 → 1501
    MAP2_projctn; MAP2/Tau projection domain

  14. NM_001375501.1 → NP_001362430.1  microtubule-associated protein 2 isoform 8

    Status: REVIEWED

    Description
    Transcript Variant: This variant (19), as well as variant 18, encodes isoform 8.
    Source sequence(s)
    AC006385, AC019106, AC079833, AC108072
    UniProtKB/TrEMBL
    A0A669KB77
    Conserved Domains (3) summary
    PTZ00449
    Location:1530 → 1770
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam08377
    Location:459 → 1587
    MAP2_projctn; MAP2/Tau projection domain
    pfam00418
    Location:1805 → 1836
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

  15. NM_001375502.1 → NP_001362431.1  microtubule-associated protein 2 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC006385, AC019106, AC079833, AC108072
    UniProtKB/TrEMBL
    A0A669KB77
    Conserved Domains (3) summary
    PTZ00449
    Location:1447 → 1687
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam00418
    Location:1691 → 1720
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    pfam08377
    Location:376 → 1504
    MAP2_projctn; MAP2/Tau projection domain

  16. NM_001375503.1 → NP_001362432.1  microtubule-associated protein 2 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC006385, AC019106, AC079833, AC108072
    UniProtKB/TrEMBL
    A0A669KB77
    Conserved Domains (4) summary
    PTZ00121
    Location:84 → 354
    PTZ00121; MAEBL; Provisional
    PTZ00449
    Location:1525 → 1764
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam00418
    Location:1768 → 1797
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    pfam08377
    Location:454 → 1581
    MAP2_projctn; MAP2/Tau projection domain

  17. NM_001375504.1 → NP_001362433.1  microtubule-associated protein 2 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC006385, AC019106, AC079833, AC108072
    UniProtKB/TrEMBL
    A0A669KB77
    Conserved Domains (3) summary
    PTZ00449
    Location:1531 → 1745
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam00418
    Location:1749 → 1778
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    pfam08377
    Location:377 → 1505
    MAP2_projctn; MAP2/Tau projection domain

  18. NM_001375505.1 → NP_001362434.1  microtubule-associated protein 2 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (67), as well as variants 1, 9, and 10, encodes isoform 1.
    Source sequence(s)
    AC006385, AC019106, AC079833, AC108072
    Consensus CDS
    CCDS2384.1
    UniProtKB/Swiss-Prot
    P11137, Q17S04, Q8IUX2, Q99975, Q99976
    UniProtKB/TrEMBL
    A0A669KB77
    Related
    ENSP00000507035.1, ENST00000682079.1
    Conserved Domains (3) summary
    PTZ00449
    Location:1448 → 1688
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam00418
    Location:1692 → 1721
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    pfam08377
    Location:377 → 1505
    MAP2_projctn; MAP2/Tau projection domain

  19. NM_001375506.1 → NP_001362435.1  microtubule-associated protein 2 isoform 12

    Status: REVIEWED

    Description
    Transcript Variant: This variant (26), as well as variant 23, encodes isoform 12.
    Source sequence(s)
    AC006385, AC019106, AC079833, AC108072
    UniProtKB/TrEMBL
    A0A669KB77
    Conserved Domains (3) summary
    PTZ00449
    Location:1407 → 1687
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam00418
    Location:1691 → 1720
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    pfam08377
    Location:377 → 1505
    MAP2_projctn; MAP2/Tau projection domain

  20. NM_001375507.1 → NP_001362436.1  microtubule-associated protein 2 isoform 14

    Status: REVIEWED

    Description
    Transcript Variant: This variant (32), as well as variant 28, encodes isoform 14.
    Source sequence(s)
    AC006385, AC019106, AC079833, AC108072
    UniProtKB/TrEMBL
    A0A669KB77
    Conserved Domains (3) summary
    PTZ00449
    Location:1444 → 1683
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam00418
    Location:1687 → 1716
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    pfam08377
    Location:373 → 1500
    MAP2_projctn; MAP2/Tau projection domain

  21. NM_001375508.1 → NP_001362437.1  microtubule-associated protein 2 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15), as well as variants 4 and 14, encodes isoform 4.
    Source sequence(s)
    AC006385, AC019106, AC079833, AC108072
    UniProtKB/TrEMBL
    Q59FX9
    Conserved Domains (2) summary
    PHA03247
    Location:176 → 306
    PHA03247; large tegument protein UL36; Provisional
    pfam00418
    Location:336 → 365
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

  22. NM_001375509.1 → NP_001362438.1  microtubule-associated protein 2 isoform 23

    Status: REVIEWED

    Source sequence(s)
    AC006385, AC079833, AC108072
    UniProtKB/TrEMBL
    Q59FX9
    Conserved Domains (3) summary
    PTZ00449
    Location:166 → 407
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam00418
    Location:411 → 440
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    pfam08377
    Location:169 → 224
    MAP2_projctn; MAP2/Tau projection domain

  23. NM_001375510.1 → NP_001362439.1  microtubule-associated protein 2 isoform 20

    Status: REVIEWED

    Description
    Transcript Variant: This variant (43), as well as variants 42 and 44, encodes isoform 20.
    Source sequence(s)
    AC006385, AC079833, AC108072
    UniProtKB/TrEMBL
    Q59FX9
    Conserved Domains (3) summary
    PTZ00449
    Location:206 → 446
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam00418
    Location:450 → 479
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    pfam08377
    Location:151 → 263
    MAP2_projctn; MAP2/Tau projection domain

  24. NM_001375526.1 → NP_001362455.1  microtubule-associated protein 2 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9), as well as variants 1, 10, and 67, encodes isoform 1.
    Source sequence(s)
    AC006385, AC079833, AC108072
    Consensus CDS
    CCDS2384.1
    UniProtKB/Swiss-Prot
    P11137, Q17S04, Q8IUX2, Q99975, Q99976
    UniProtKB/TrEMBL
    A0A669KB77
    Conserved Domains (3) summary
    PTZ00449
    Location:1448 → 1688
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam00418
    Location:1692 → 1721
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    pfam08377
    Location:377 → 1505
    MAP2_projctn; MAP2/Tau projection domain

  25. NM_001375527.1 → NP_001362456.1  microtubule-associated protein 2 isoform 12

    Status: REVIEWED

    Description
    Transcript Variant: This variant (23), as well as variant 26, encodes isoform 12.
    Source sequence(s)
    AC006385, AC079833, AC108072
    UniProtKB/TrEMBL
    A0A669KB77
    Conserved Domains (3) summary
    PTZ00449
    Location:1407 → 1687
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam00418
    Location:1691 → 1720
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    pfam08377
    Location:377 → 1505
    MAP2_projctn; MAP2/Tau projection domain

  26. NM_001375528.1 → NP_001362457.1  microtubule-associated protein 2 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16), as well as variants 6 and 7, encodes isoform 6.
    Source sequence(s)
    AC006385, AC079833, AC108072
    Consensus CDS
    CCDS86916.1
    UniProtKB/TrEMBL
    A0A669KB77
    Related
    ENSP00000392164.1, ENST00000447185.5
    Conserved Domains (3) summary
    PTZ00449
    Location:1444 → 1684
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam00418
    Location:1688 → 1717
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    pfam08377
    Location:373 → 1501
    MAP2_projctn; MAP2/Tau projection domain

  27. NM_001375529.1 → NP_001362458.1  microtubule-associated protein 2 isoform 27

    Status: REVIEWED

    Description
    Transcript Variant: This variant (51), as well as variants 54 and 55, encodes isoform 27.
    Source sequence(s)
    AC006385, AC079833, AC108072
    UniProtKB/TrEMBL
    A8K5Y1, Q59FX9
    Conserved Domains (1) summary
    pfam00418
    Location:335 → 364
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

  28. NM_001375530.1 → NP_001362459.1  microtubule-associated protein 2 isoform 36

    Status: REVIEWED

    Description
    Transcript Variant: This variant (52), as well as variant 53, encodes isoform 36.
    Source sequence(s)
    AC006385, AC079833, AC108072
    UniProtKB/TrEMBL
    A8K5Y1, Q59FX9
    Conserved Domains (1) summary
    pfam00418
    Location:335 → 364
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

  29. NM_001375531.1 → NP_001362460.1  microtubule-associated protein 2 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC006385, AC079833, AC108072
    UniProtKB/TrEMBL
    A0A669KB77
    Conserved Domains (3) summary
    PTZ00449
    Location:1489 → 1769
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam00418
    Location:1773 → 1802
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    pfam08377
    Location:459 → 1587
    MAP2_projctn; MAP2/Tau projection domain

  30. NM_001375532.1 → NP_001362461.1  microtubule-associated protein 2 isoform 36

    Status: REVIEWED

    Description
    Transcript Variant: This variant (53), as well as variant 52, encodes isoform 36.
    Source sequence(s)
    AC006385, AC079833, AC108072
    UniProtKB/TrEMBL
    A8K5Y1, Q59FX9
    Conserved Domains (1) summary
    pfam00418
    Location:335 → 364
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

  31. NM_001375533.1 → NP_001362462.1  microtubule-associated protein 2 isoform 27

    Status: REVIEWED

    Description
    Transcript Variant: This variant (54), as well as variants 51 and 55, encodes isoform 27.
    Source sequence(s)
    AC006385, AC079833, AC108072
    UniProtKB/TrEMBL
    A8K5Y1, Q59FX9
    Conserved Domains (1) summary
    pfam00418
    Location:335 → 364
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

  32. NM_001375534.1 → NP_001362463.1  microtubule-associated protein 2 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10), as well as variants 1, 9, and 67, encodes isoform 1.
    Source sequence(s)
    AC006385, AC079833, AC108072
    Consensus CDS
    CCDS2384.1
    UniProtKB/Swiss-Prot
    P11137, Q17S04, Q8IUX2, Q99975, Q99976
    UniProtKB/TrEMBL
    A0A669KB77
    Conserved Domains (3) summary
    PTZ00449
    Location:1448 → 1688
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam00418
    Location:1692 → 1721
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    pfam08377
    Location:377 → 1505
    MAP2_projctn; MAP2/Tau projection domain

  33. NM_001375535.1 → NP_001362464.1  microtubule-associated protein 2 isoform 22

    Status: REVIEWED

    Source sequence(s)
    AC006385, AC079833, AC108072
    UniProtKB/TrEMBL
    Q59FX9
    Conserved Domains (2) summary
    PTZ00449
    Location:170 → 413
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam00418
    Location:417 → 446
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

  34. NM_001375536.1 → NP_001362465.1  microtubule-associated protein 2 isoform 20

    Status: REVIEWED

    Description
    Transcript Variant: This variant (44), as well as variants 42 and 43, encodes isoform 20.
    Source sequence(s)
    AC006385, AC079833, AC108072
    UniProtKB/TrEMBL
    Q59FX9
    Conserved Domains (3) summary
    PTZ00449
    Location:206 → 446
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam00418
    Location:450 → 479
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    pfam08377
    Location:151 → 263
    MAP2_projctn; MAP2/Tau projection domain

  35. NM_001375537.1 → NP_001362466.1  microtubule-associated protein 2 isoform 8

    Status: REVIEWED

    Description
    Transcript Variant: This variant (18), as well as variant 19, encodes isoform 8.
    Source sequence(s)
    AC006385, AC079833, AC108072
    UniProtKB/TrEMBL
    A0A669KB77
    Related
    ENSP00000501117.1, ENST00000673860.1
    Conserved Domains (3) summary
    PTZ00449
    Location:1530 → 1770
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam08377
    Location:459 → 1587
    MAP2_projctn; MAP2/Tau projection domain
    pfam00418
    Location:1805 → 1836
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

  36. NM_001375538.1 → NP_001362467.1  microtubule-associated protein 2 isoform 21

    Status: REVIEWED

    Source sequence(s)
    AC006385, AC079833, AC108072
    UniProtKB/TrEMBL
    Q59FX9
    Conserved Domains (3) summary
    PTZ00449
    Location:206 → 445
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam00418
    Location:449 → 478
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    pfam08377
    Location:151 → 262
    MAP2_projctn; MAP2/Tau projection domain

  37. NM_001375539.1 → NP_001362468.1  microtubule-associated protein 2 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC006385, AC079833, AC108072
    UniProtKB/TrEMBL
    A0A669KB77
    Conserved Domains (4) summary
    PTZ00121
    Location:84 → 355
    PTZ00121; MAEBL; Provisional
    PTZ00449
    Location:1526 → 1766
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam00418
    Location:1770 → 1799
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    pfam08377
    Location:455 → 1583
    MAP2_projctn; MAP2/Tau projection domain

  38. NM_001375540.1 → NP_001362469.1  microtubule-associated protein 2 isoform 35

    Status: REVIEWED

    Source sequence(s)
    AC006385, AC079833, AC108072
    UniProtKB/TrEMBL
    Q59FX9
    Conserved Domains (3) summary
    PTZ00449
    Location:205 → 444
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam00418
    Location:448 → 477
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    pfam08377
    Location:150 → 261
    MAP2_projctn; MAP2/Tau projection domain

  39. NM_001375541.1 → NP_001362470.1  microtubule-associated protein 2 isoform 26

    Status: REVIEWED

    Source sequence(s)
    AC006385, AC079833, AC108072
    UniProtKB/TrEMBL
    Q59FX9
    Conserved Domains (3) summary
    PTZ00449
    Location:155 → 377
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam00418
    Location:381 → 410
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    pfam08377
    Location:143 → 194
    MAP2_projctn; MAP2/Tau projection domain

  40. NM_001375542.1 → NP_001362471.1  microtubule-associated protein 2 isoform 28

    Status: REVIEWED

    Source sequence(s)
    AC006385, AC079833, AC108072
    UniProtKB/TrEMBL
    A8K5Y1, Q59FX9
    Conserved Domains (1) summary
    pfam00418
    Location:334 → 363
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

  41. NM_001375543.1 → NP_001362472.1  microtubule-associated protein 2 isoform 31

    Status: REVIEWED

    Source sequence(s)
    AC006385, AC079833, AC108072
    UniProtKB/TrEMBL
    A0A669KB77
    Conserved Domains (3) summary
    PTZ00449
    Location:1448 → 1687
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam00418
    Location:1691 → 1720
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    pfam08377
    Location:377 → 1504
    MAP2_projctn; MAP2/Tau projection domain

  42. NM_001375544.1 → NP_001362473.1  microtubule-associated protein 2 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC006385, AC079833, AC108072
    UniProtKB/TrEMBL
    A0A669KB77
    Conserved Domains (3) summary
    PTZ00449
    Location:1447 → 1687
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam00418
    Location:1691 → 1720
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    pfam08377
    Location:376 → 1504
    MAP2_projctn; MAP2/Tau projection domain

  43. NM_001375545.1 → NP_001362474.1  microtubule-associated protein 2 isoform 14

    Status: REVIEWED

    Description
    Transcript Variant: This variant (28), as well as variant 32, encodes isoform 14.
    Source sequence(s)
    AC006385, AC079833, AC108072
    UniProtKB/TrEMBL
    A0A669KB77
    Conserved Domains (3) summary
    PTZ00449
    Location:1444 → 1683
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam00418
    Location:1687 → 1716
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    pfam08377
    Location:373 → 1500
    MAP2_projctn; MAP2/Tau projection domain

  44. NM_001375546.1 → NP_001362475.1  microtubule-associated protein 2 isoform 32

    Status: REVIEWED

    Source sequence(s)
    AC006385, AC079833, AC108072
    UniProtKB/TrEMBL
    A0A669KB77
    Conserved Domains (3) summary
    PTZ00449
    Location:1403 → 1683
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam00418
    Location:1687 → 1716
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    pfam08377
    Location:373 → 1501
    MAP2_projctn; MAP2/Tau projection domain

  45. NM_001375548.1 → NP_001362477.1  microtubule-associated protein 2 isoform 33

    Status: REVIEWED

    Source sequence(s)
    AC006385, AC079833, AC108072
    UniProtKB/TrEMBL
    A0A669KB77
    Conserved Domains (3) summary
    PTZ00449
    Location:1443 → 1683
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam00418
    Location:1687 → 1716
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    pfam08377
    Location:372 → 1500
    MAP2_projctn; MAP2/Tau projection domain

  46. NM_001375551.1 → NP_001362480.1  microtubule-associated protein 2 isoform 16

    Status: REVIEWED

    Description
    Transcript Variant: This variant (36), as well as variants 12, 34, and 35, encodes isoform 16.
    Source sequence(s)
    AC006385, AC079833
    UniProtKB/TrEMBL
    A0A669KB77
    Conserved Domains (3) summary
    PTZ00449
    Location:1290 → 1530
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam00418
    Location:1534 → 1563
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    pfam08377
    Location:219 → 1347
    MAP2_projctn; MAP2/Tau projection domain

  47. NM_001375552.1 → NP_001362481.1  microtubule-associated protein 2 isoform 16

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12), as well as variants 34, 35, and 36, encodes isoform 16.
    Source sequence(s)
    AC006385, AC079833
    UniProtKB/TrEMBL
    A0A669KB77
    Conserved Domains (3) summary
    PTZ00449
    Location:1290 → 1530
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam00418
    Location:1534 → 1563
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    pfam08377
    Location:219 → 1347
    MAP2_projctn; MAP2/Tau projection domain

  48. NM_001375553.1 → NP_001362482.1  microtubule-associated protein 2 isoform 29

    Status: REVIEWED

    Description
    Transcript Variant: This variant (57), as well as variant 58, encodes isoform 29.
    Source sequence(s)
    AC006385, AC079833
    Conserved Domains (3) summary
    PTZ00449
    Location:49 → 289
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam00418
    Location:293 → 322
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    pfam08377
    Location:1 → 106
    MAP2_projctn; MAP2/Tau projection domain

  49. NM_001375554.1 → NP_001362483.1  microtubule-associated protein 2 isoform 29

    Status: REVIEWED

    Description
    Transcript Variant: This variant (58), as well as variant 57, encodes isoform 29.
    Source sequence(s)
    AC006385, AC079833
    Conserved Domains (3) summary
    PTZ00449
    Location:49 → 289
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam00418
    Location:293 → 322
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    pfam08377
    Location:1 → 106
    MAP2_projctn; MAP2/Tau projection domain

  50. NM_001375555.1 → NP_001362484.1  microtubule-associated protein 2 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC006385, AC079833
    UniProtKB/TrEMBL
    A0A669KB77
    Conserved Domains (3) summary
    PTZ00449
    Location:1290 → 1530
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam00418
    Location:1534 → 1563
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    pfam08377
    Location:219 → 1347
    MAP2_projctn; MAP2/Tau projection domain

  51. NM_001375556.1 → NP_001362485.1  microtubule-associated protein 2 isoform 16

    Status: REVIEWED

    Description
    Transcript Variant: This variant (34), as well as variants 12, 35, and 36, encodes isoform 16.
    Source sequence(s)
    AC006385, AC079833
    UniProtKB/TrEMBL
    A0A669KB77
    Conserved Domains (3) summary
    PTZ00449
    Location:1290 → 1530
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam00418
    Location:1534 → 1563
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    pfam08377
    Location:219 → 1347
    MAP2_projctn; MAP2/Tau projection domain

  52. NM_001375557.1 → NP_001362486.1  microtubule-associated protein 2 isoform 16

    Status: REVIEWED

    Description
    Transcript Variant: This variant (35), as well as variants 12, 34, and 36, encodes isoform 16.
    Source sequence(s)
    AC006385, AC079833
    UniProtKB/TrEMBL
    A0A669KB77
    Conserved Domains (3) summary
    PTZ00449
    Location:1290 → 1530
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam00418
    Location:1534 → 1563
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    pfam08377
    Location:219 → 1347
    MAP2_projctn; MAP2/Tau projection domain

  53. NM_001375558.1 → NP_001362487.1  microtubule-associated protein 2 isoform 17

    Status: REVIEWED

    Source sequence(s)
    AC006385, AC079833
    UniProtKB/TrEMBL
    A0A669KB77
    Conserved Domains (3) summary
    PTZ00449
    Location:1290 → 1529
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam00418
    Location:1533 → 1562
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    pfam08377
    Location:219 → 1346
    MAP2_projctn; MAP2/Tau projection domain

  54. NM_001375559.1 → NP_001362488.1  microtubule-associated protein 2 isoform 34

    Status: REVIEWED

    Source sequence(s)
    AC006385, AC079833
    UniProtKB/TrEMBL
    A0A669KB77
    Conserved Domains (3) summary
    PTZ00449
    Location:1249 → 1529
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam00418
    Location:1533 → 1562
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    pfam08377
    Location:219 → 1347
    MAP2_projctn; MAP2/Tau projection domain

  55. NM_001375583.1 → NP_001362512.1  microtubule-associated protein 2 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (60), as well as variants 2, 8, and 11, encodes isoform 2.
    Source sequence(s)
    AC006385, AC019106, AC079833, AC108072
    Consensus CDS
    CCDS2385.1
    UniProtKB/TrEMBL
    A8K5Y1, Q59FX9
    Conserved Domains (1) summary
    pfam00418
    Location:367 → 398
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

  56. NM_002374.4 → NP_002365.3  microtubule-associated protein 2 isoform 1

    See identical proteins and their annotated locations for NP_002365.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) includes three alternate in-frame exons, compared to variant 2, resulting in the longest isoform (1).
    Source sequence(s)
    AC006385, AC079833, AC108072
    Consensus CDS
    CCDS2384.1
    UniProtKB/Swiss-Prot
    P11137, Q17S04, Q8IUX2, Q99975, Q99976
    UniProtKB/TrEMBL
    A0A669KB77
    Related
    ENSP00000353508.4, ENST00000360351.8
    Conserved Domains (3) summary
    PTZ00449
    Location:1448 → 1688
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam00418
    Location:1692 → 1721
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    pfam08377
    Location:377 → 1505
    MAP2_projctn; MAP2/Tau projection domain

  57. NM_031845.3 → NP_114033.2  microtubule-associated protein 2 isoform 2

    See identical proteins and their annotated locations for NP_114033.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents the shortest transcript and encodes the shortest isoform (2). Variants 2, 8, 11, and 60 all encode the same isoform (2).
    Source sequence(s)
    AC006385, AC079833, AC108072
    Consensus CDS
    CCDS2385.1
    UniProtKB/TrEMBL
    A8K5Y1, Q59FX9
    Related
    ENSP00000355290.4, ENST00000361559.8
    Conserved Domains (1) summary
    pfam00418
    Location:367 → 398
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

  58. NM_031847.3 → NP_114035.2  microtubule-associated protein 2 isoform 4

    See identical proteins and their annotated locations for NP_114035.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) includes an alternate in-frame exon, compared to variant 2, resulting in a longer protein (isoform 4), compared to isoform 2.
    Source sequence(s)
    AC006385, AC079833, AC108072
    UniProtKB/TrEMBL
    Q59FX9
    Conserved Domains (2) summary
    PHA03247
    Location:176 → 306
    PHA03247; large tegument protein UL36; Provisional
    pfam00418
    Location:336 → 365
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

RNA

  1. NR_164694.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC006385, AC079833

  2. NR_164695.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC006385, AC079833

  3. NR_164696.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC006385, AC079833

  4. NR_164697.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC006385, AC079833

  5. NR_164698.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC006385, AC079833

  6. NR_164699.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC006385, AC079833

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    209424047..209734112
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024452896.2 → XP_024308664.1  microtubule-associated protein 2 isoform X6

    UniProtKB/TrEMBL
    A0A024R3Z1, A0A024R431, A0A669KB77
    Related
    ENSP00000515868.1, ENST00000704357.1
    Conserved Domains (3) summary
    pfam00418
    Location:1692 → 1721
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    pfam08377
    Location:377 → 1505
    MAP2_projctn; MAP2/Tau projection domain
    cl25751
    Location:1448 → 1688
    DUF4045; Domain of unknown function (DUF4045)

  2. XM_047444387.1 → XP_047300343.1  microtubule-associated protein 2 isoform X5

  3. XM_047444388.1 → XP_047300344.1  microtubule-associated protein 2 isoform X7

  4. XM_024452894.2 → XP_024308662.1  microtubule-associated protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A669KB77
    Conserved Domains (3) summary
    pfam00418
    Location:1745 → 1774
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    pfam08377
    Location:373 → 1501
    MAP2_projctn; MAP2/Tau projection domain
    cl25751
    Location:1527 → 1741
    DUF4045; Domain of unknown function (DUF4045)

  5. XM_024452897.2 → XP_024308665.1  microtubule-associated protein 2 isoform X8

    UniProtKB/TrEMBL
    A0A669KB77
    Conserved Domains (3) summary
    pfam00418
    Location:1688 → 1717
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    pfam08377
    Location:373 → 1501
    MAP2_projctn; MAP2/Tau projection domain
    cl25751
    Location:1444 → 1684
    DUF4045; Domain of unknown function (DUF4045)

  6. XM_017004116.3 → XP_016859605.1  microtubule-associated protein 2 isoform X10

    UniProtKB/TrEMBL
    A0A669KB77

  7. XM_047444393.1 → XP_047300349.1  microtubule-associated protein 2 isoform X17

    Conserved Domains (1) summary
    pfam00418
    Location:335 → 364
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

  8. XM_011511195.3 → XP_011509497.1  microtubule-associated protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A669KB77
    Conserved Domains (2) summary
    pfam00418
    Location:1748 → 1777
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    pfam08377
    Location:376 → 1504
    MAP2_projctn; MAP2/Tau projection domain

  9. XM_024452902.2 → XP_024308670.1  microtubule-associated protein 2 isoform X11

    UniProtKB/TrEMBL
    A0A669KB77
    Conserved Domains (3) summary
    PTZ00449
    Location:1447 → 1687
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam00418
    Location:1691 → 1720
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    pfam08377
    Location:376 → 1504
    MAP2_projctn; MAP2/Tau projection domain

  10. XM_024452895.2 → XP_024308663.1  microtubule-associated protein 2 isoform X4

    UniProtKB/TrEMBL
    A0A669KB77
    Conserved Domains (3) summary
    pfam00418
    Location:1744 → 1773
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    pfam08377
    Location:372 → 1500
    MAP2_projctn; MAP2/Tau projection domain
    cl25751
    Location:1526 → 1740
    DUF4045; Domain of unknown function (DUF4045)

  11. XM_024452899.2 → XP_024308667.1  microtubule-associated protein 2 isoform X9

    UniProtKB/TrEMBL
    A0A669KB77
    Conserved Domains (3) summary
    pfam00418
    Location:1687 → 1716
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    pfam08377
    Location:372 → 1500
    MAP2_projctn; MAP2/Tau projection domain
    cl25751
    Location:1443 → 1683
    DUF4045; Domain of unknown function (DUF4045)

  12. XM_024452907.2 → XP_024308675.1  microtubule-associated protein 2 isoform X12

    UniProtKB/TrEMBL
    A0A669KB77
    Conserved Domains (3) summary
    PTZ00449
    Location:1443 → 1683
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam00418
    Location:1687 → 1716
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    pfam08377
    Location:372 → 1500
    MAP2_projctn; MAP2/Tau projection domain

  13. XM_017004128.3 → XP_016859617.1  microtubule-associated protein 2 isoform X13

    UniProtKB/TrEMBL
    A0A669KB77

  14. XM_017004129.3 → XP_016859618.1  microtubule-associated protein 2 isoform X14

    UniProtKB/TrEMBL
    A0A669KB77

  15. XM_024452893.2 → XP_024308661.1  microtubule-associated protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A669KB77
    Conserved Domains (3) summary
    PTZ00449
    Location:1531 → 1745
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam00418
    Location:1749 → 1778
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    pfam08377
    Location:377 → 1505
    MAP2_projctn; MAP2/Tau projection domain

  16. XM_047444386.1 → XP_047300342.1  microtubule-associated protein 2 isoform X3

  17. XM_017004113.3 → XP_016859602.1  microtubule-associated protein 2 isoform X4

    UniProtKB/TrEMBL
    A0A669KB77
    Conserved Domains (3) summary
    pfam00418
    Location:1744 → 1773
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    pfam08377
    Location:372 → 1500
    MAP2_projctn; MAP2/Tau projection domain
    cl25751
    Location:1526 → 1740
    DUF4045; Domain of unknown function (DUF4045)

  18. XM_017004112.3 → XP_016859601.1  microtubule-associated protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A669KB77
    Conserved Domains (3) summary
    PTZ00449
    Location:1531 → 1745
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam00418
    Location:1749 → 1778
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    pfam08377
    Location:377 → 1505
    MAP2_projctn; MAP2/Tau projection domain

  19. XM_017004114.3 → XP_016859603.1  microtubule-associated protein 2 isoform X6

    UniProtKB/TrEMBL
    A0A024R3Z1, A0A024R431, A0A669KB77
    Conserved Domains (3) summary
    pfam00418
    Location:1692 → 1721
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    pfam08377
    Location:377 → 1505
    MAP2_projctn; MAP2/Tau projection domain
    cl25751
    Location:1448 → 1688
    DUF4045; Domain of unknown function (DUF4045)

  20. XM_047444389.1 → XP_047300345.1  microtubule-associated protein 2 isoform X7

  21. XM_011511196.4 → XP_011509498.1  microtubule-associated protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A669KB77
    Conserved Domains (3) summary
    pfam00418
    Location:1745 → 1774
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    pfam08377
    Location:373 → 1501
    MAP2_projctn; MAP2/Tau projection domain
    cl25751
    Location:1527 → 1741
    DUF4045; Domain of unknown function (DUF4045)

  22. XM_047444390.1 → XP_047300346.1  microtubule-associated protein 2 isoform X15

  23. XM_047444392.1 → XP_047300348.1  microtubule-associated protein 2 isoform X16

    Conserved Domains (2) summary
    PTZ00449
    Location:175 → 389
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam00418
    Location:393 → 422
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

  24. XM_011511197.4 → XP_011509499.1  microtubule-associated protein 2 isoform X4

    UniProtKB/TrEMBL
    A0A669KB77
    Conserved Domains (3) summary
    pfam00418
    Location:1744 → 1773
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    pfam08377
    Location:372 → 1500
    MAP2_projctn; MAP2/Tau projection domain
    cl25751
    Location:1526 → 1740
    DUF4045; Domain of unknown function (DUF4045)

  25. XM_047444391.1 → XP_047300347.1  microtubule-associated protein 2 isoform X15

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    209904237..210214222
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054342093.1 → XP_054198068.1  microtubule-associated protein 2 isoform X6

    UniProtKB/TrEMBL
    A0A024R3Z1, A0A024R431

  2. XM_054342092.1 → XP_054198067.1  microtubule-associated protein 2 isoform X5

  3. XM_054342095.1 → XP_054198070.1  microtubule-associated protein 2 isoform X7

  4. XM_054342086.1 → XP_054198061.1  microtubule-associated protein 2 isoform X3

  5. XM_054342097.1 → XP_054198072.1  microtubule-associated protein 2 isoform X8

  6. XM_054342099.1 → XP_054198074.1  microtubule-associated protein 2 isoform X10

  7. XM_054342107.1 → XP_054198082.1  microtubule-associated protein 2 isoform X17

  8. XM_054342085.1 → XP_054198060.1  microtubule-associated protein 2 isoform X2

  9. XM_054342100.1 → XP_054198075.1  microtubule-associated protein 2 isoform X11

  10. XM_054342090.1 → XP_054198065.1  microtubule-associated protein 2 isoform X4

  11. XM_054342098.1 → XP_054198073.1  microtubule-associated protein 2 isoform X9

  12. XM_054342101.1 → XP_054198076.1  microtubule-associated protein 2 isoform X12

  13. XM_054342102.1 → XP_054198077.1  microtubule-associated protein 2 isoform X13

  14. XM_054342103.1 → XP_054198078.1  microtubule-associated protein 2 isoform X14

  15. XM_054342084.1 → XP_054198059.1  microtubule-associated protein 2 isoform X1

  16. XM_054342088.1 → XP_054198063.1  microtubule-associated protein 2 isoform X3

  17. XM_054342089.1 → XP_054198064.1  microtubule-associated protein 2 isoform X4

  18. XM_054342083.1 → XP_054198058.1  microtubule-associated protein 2 isoform X1

  19. XM_054342094.1 → XP_054198069.1  microtubule-associated protein 2 isoform X6

    UniProtKB/TrEMBL
    A0A024R3Z1, A0A024R431

  20. XM_054342096.1 → XP_054198071.1  microtubule-associated protein 2 isoform X7

  21. XM_054342087.1 → XP_054198062.1  microtubule-associated protein 2 isoform X3

  22. XM_054342104.1 → XP_054198079.1  microtubule-associated protein 2 isoform X15

  23. XM_054342106.1 → XP_054198081.1  microtubule-associated protein 2 isoform X16

  24. XM_054342091.1 → XP_054198066.1  microtubule-associated protein 2 isoform X4

  25. XM_054342105.1 → XP_054198080.1  microtubule-associated protein 2 isoform X15

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_031846.2: Suppressed sequence

    Description
    NM_031846.2: This RefSeq was permanently suppressed because currently there is insufficient support for the exon combination represented in this transcript.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P11137.4 GenPept UniProtKB/Swiss-Prot:P11137

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