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Irp-1B Iron regulatory protein 1B [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41269, updated on 2-Nov-2024

Summary

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Official Symbol
Irp-1Bprovided by FlyBase
Official Full Name
Iron regulatory protein 1Bprovided by FlyBase
Primary source
FLYBASE:FBgn0024957
Locus tag
Dmel_CG6342
See related
AllianceGenome:FB:FBgn0024957
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
144037_at; C-Acon; cAcon; cACON; CG6342; dIRP; Dmel\CG6342; IRF; IRP; IRP-1; irp-1B; IRP-1B; IRP1; irp1B; IRP1B
Summary
Enables aconitate hydratase activity. Predicted to be involved in citrate metabolic process and tricarboxylic acid cycle. Located in cytosol and nucleus. Is expressed in adult heart and organism. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to several human genes including ACO1 (aconitase 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See Irp-1B in Genome Data Viewer
Location:
86B4-86B4; 3-49 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (10408618..10412869, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (6234340..6238591, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene mir-994 stem loop Neighboring gene mir-318 stem loop Neighboring gene Rrp46 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Using PRINS for gene mapping in polytene chromosomes. Gu HF, et al. Chromosome Res, 1997 Nov. PMID 9421263
  2. The mRNA-binding protein which controls ferritin and transferrin receptor expression is conserved during evolution. Rothenberger S, et al. Nucleic Acids Res, 1990 Mar 11. PMID 2157191, Free PMC Article
  3. Translational regulation of mammalian and Drosophila citric acid cycle enzymes via iron-responsive elements. Gray NK, et al. Proc Natl Acad Sci U S A, 1996 May 14. PMID 8643505, Free PMC Article
  4. Iron-regulatory protein-1 (IRP-1) is highly conserved in two invertebrate species--characterization of IRP-1 homologues in Drosophila melanogaster and Caenorhabditis elegans. Muckenthaler M, et al. Eur J Biochem, 1998 Jun 1. PMID 9660175
  5. Differential translational regulation of IRE-containing mRNAs in Drosophila melanogaster by endogenous IRP and a constitutive human IRP1 mutant. Surdej P, et al. Insect Biochem Mol Biol, 2008 Sep. PMID 18675912

See all (71) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Downregulating Irp-1B in neurons of single-housed Abeta42 expressing and control flies rescued both survival and motor performance deficits. Authors provide novel evidence that increased cerebral expression of Irp-1B may underlie worsened behavioral outcome in socially deprived flies and can additionally modulate AD-like phenotypes.
    Title: Decreased cerebral Irp-1B limits impact of social isolation in wild type and Alzheimer's disease modeled in Drosophila melanogaster.
  2. muscle-specific overexpression of IRP-1A, but not of IRP-1B, resulted in pre-adult lethality, underscoring the importance of the biochemical difference between the two proteins;only IRP-1A can bind to iron-responsive elements
    Title: Of two cytosolic aconitases expressed in Drosophila, only one functions as an iron-regulatory protein.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aconitate hydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aconitate hydratase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables aconitate hydratase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
NOT enables iron-responsive element binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in citrate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tricarboxylic acid cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
iron regulatory protein 1B
Names
CG6342-PA
Irp-1B-PA
c-aconitase
cytoplasmic aconitase
cytosolic aconitase
iron regulatory factor
iron regulatory protein
NP_524303.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    10408618..10412869 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079579.3 → NP_524303.2  iron regulatory protein 1B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524303.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9NFX2, Q9VGZ3
    Related
    FBpp0081736
    Conserved Domains (3) summary
    cd01586
    Location:86 → 576
    AcnA_IRP; Aconitase A catalytic domain
    cd01580
    Location:680 → 849
    AcnA_IRP_Swivel; Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group ...
    PTZ00092
    Location:1 → 899
    PTZ00092; aconitate hydratase-like protein; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O76935 O76935
Q9NFX2 Q9NFX2
Q9VGZ3 Q9VGZ3

Gene LinkOut

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