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CG8112 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41033, updated on 2-Nov-2024

Summary

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Official Symbol
CG8112provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0037612
Locus tag
Dmel_CG8112
See related
AllianceGenome:FB:FBgn0037612
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
ACAT; ACAT1; Dmel\CG8112
Summary
Predicted to enable O-acyltransferase activity. Predicted to be involved in cholesterol metabolic process. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including amnioserosa; embryonic/larval hemocyte; procrystal cell; and yolk nucleus. Human ortholog(s) of this gene implicated in Chagas disease; coronary artery disease; and hepatocellular carcinoma. Orthologous to several human genes including SOAT2 (sterol O-acyltransferase 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See CG8112 in Genome Data Viewer
Location:
85A8-85A8; 3-48 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (8712933..8715263)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (4538655..4540985)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44937 Neighboring gene uncharacterized protein Neighboring gene hunchback Neighboring gene Cyclin-dependent kinase subunit 85A Neighboring gene Transmembrane protein 216 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mutations in the midway gene disrupt a Drosophila acyl coenzyme A: diacylglycerol acyltransferase. Buszczak M, et al. Genetics, 2002 Apr. PMID 11973306, Free PMC Article
  2. Identification of hunchback cis-regulatory DNA conferring temporal expression in neuroblasts and neurons. Hirono K, et al. Gene Expr Patterns, 2012 Jan-Feb. PMID 22033538, Free PMC Article
  3. Cholesterol Dietary Intake and Tumor Cell Homeostasis Drive Early Epithelial Tumorigenesis: A Potential Modelization of Early Prostate Tumorigenesis. Vialat M, et al. Cancers (Basel), 2024 Jun 6. PMID 38893271, Free PMC Article
  4. An Adult Drosophila Glioma Model for Studying Pathometabolic Pathways of Gliomagenesis. Chi KC, et al. Mol Neurobiol, 2019 Jun. PMID 30357574
  5. SEIPIN Regulates Lipid Droplet Expansion and Adipocyte Development by Modulating the Activity of Glycerol-3-phosphate Acyltransferase. Pagac M, et al. Cell Rep, 2016 Nov 1. PMID 27806294, Free PMC Article

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables O-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cholesterol O-acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cholesterol homeostasis IEA
Inferred from Electronic Annotation
more info
  
involved_in cholesterol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG8112-PB
CG8112-PC
CG8112-PD
NP_001246991.1
NP_001287240.1
NP_731269.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    8712933..8715263
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001300311.1 → NP_001287240.1  uncharacterized protein Dmel_CG8112, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287240.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LGV0

  2. NM_169235.4 → NP_731269.2  uncharacterized protein Dmel_CG8112, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731269.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MYW9, Q9VHN2
    Conserved Domains (1) summary
    cl00738
    Location:231 → 473
    MBOAT; MBOAT, membrane-bound O-acyltransferase family

  3. NM_001260062.2 → NP_001246991.1  uncharacterized protein Dmel_CG8112, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246991.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D3DMP4
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4LGV0 A0A0B4LGV0
D3DMP4 D3DMP4
Q8MYW9 Q8MYW9

Gene LinkOut

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