U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ap2a2 adaptor related protein complex 2 subunit alpha 2 [ Xenopus tropicalis (tropical clawed frog) ]

Gene ID: 407867, updated on 4-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
ap2a2provided by Xenbase
Official Full Name
adaptor related protein complex 2 subunit alpha 2provided by Xenbase
Primary source
Xenbase:XB-GENE-486024
See related
Ensembl:ENSXETG00000025765 AllianceGenome:Xenbase:XB-GENE-486024
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus tropicalis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as
hip9; hypj; adtab; ap2a1; clapa2; ap2a2-3
Summary
Predicted to enable clathrin adaptor activity. Predicted to act upstream of or within clathrin-dependent endocytosis and intracellular protein transport. Predicted to be located in clathrin-coated pit. Predicted to be part of AP-2 adaptor complex. Orthologous to human AP2A2 (adaptor related protein complex 2 subunit alpha 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See ap2a2 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
24
Annotation release Status Assembly Chr Location
104 current UCB_Xtro_10.0 (GCF_000004195.4) 4 NC_030680.2 (30656655..30708007, complement)
103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 4 NC_030680.1 (34495602..34546835, complement)

Chromosome 4 - NC_030680.2Genomic Context describing neighboring genes Neighboring gene mucin 2, oligomeric mucus/gel-forming Neighboring gene mucin 6, oligomeric mucus/gel-forming Neighboring gene uncharacterized LOC116410339 Neighboring gene chitinase domain containing 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

Clone Names

  • MGC69489

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables clathrin adaptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within clathrin-dependent endocytosis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within endocytosis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of AP-2 adaptor complex IEA
Inferred from Electronic Annotation
more info
  
located_in clathrin-coated pit IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of membrane coat IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
AP-2 complex subunit alpha-2
Names
adaptor related protein complex 2 alpha 2 subunit
adaptor-related protein complex 2, alpha 1 subunit
alpha-adaptin
daptor-related protein complex 2, alpha 2 subunit

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001209.2 → NP_001001209.1  AP-2 complex subunit alpha-2

    See identical proteins and their annotated locations for NP_001001209.1

    Status: PROVISIONAL

    Source sequence(s)
    BC067918
    UniProtKB/TrEMBL
    F6QM48, Q6NVT5
    Related
    ENSXETP00000056907.4, ENSXETT00000056907.4
    Conserved Domains (4) summary
    sd00044
    Location:332 → 355
    HEAT; HEAT repeat [structural motif]
    pfam01602
    Location:29 → 591
    Adaptin_N; Adaptin N terminal region
    pfam02296
    Location:826 → 934
    Alpha_adaptin_C; Alpha adaptin AP2, C-terminal domain
    pfam02883
    Location:713 → 821
    Alpha_adaptinC2; Adaptin C-terminal domain

RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

  1. NC_030680.2 Reference UCB_Xtro_10.0 Primary Assembly

    Range
    30656655..30708007 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_012960784.3 → XP_012816238.1  AP-2 complex subunit alpha-2 isoform X4

    UniProtKB/TrEMBL
    A0A6I8RXI2, F6QM48
    Related
    ENSXETP00000085297.2, ENSXETT00000067438.2
    Conserved Domains (4) summary
    smart00809
    Location:743 → 846
    Alpha_adaptinC2; Adaptin C-terminal domain
    sd00044
    Location:332 → 355
    HEAT; HEAT repeat [structural motif]
    pfam01602
    Location:29 → 591
    Adaptin_N; Adaptin N terminal region
    pfam02296
    Location:852 → 960
    Alpha_adaptin_C; Alpha adaptin AP2, C-terminal domain

  2. XM_012960782.3 → XP_012816236.1  AP-2 complex subunit alpha-2 isoform X2

    UniProtKB/TrEMBL
    A0A6I8Q386, A0A6I8SD08
    Related
    ENSXETP00000091154.2, ENSXETT00000076182.2
    Conserved Domains (4) summary
    pfam01602
    Location:29 → 591
    Adaptin_N; Adaptin N terminal region
    pfam02296
    Location:897 → 1005
    Alpha_adaptin_C; Alpha adaptin AP2, C-terminal domain
    pfam02883
    Location:784 → 890
    Alpha_adaptinC2; Adaptin C-terminal domain
    sd00044
    Location:332 → 355
    HEAT; HEAT repeat [structural motif]

  3. XM_031899971.1 → XP_031755831.1  AP-2 complex subunit alpha-2 isoform X3

    UniProtKB/TrEMBL
    A0A6I8Q386, A0A8J1JGN8
    Related
    ENSXETP00000066986.2, ENSXETT00000086409.2
    Conserved Domains (4) summary
    smart00809
    Location:763 → 866
    Alpha_adaptinC2; Adaptin C-terminal domain
    sd00044
    Location:332 → 355
    HEAT; HEAT repeat [structural motif]
    pfam02296
    Location:872 → 980
    Alpha_adaptin_C; Alpha adaptin AP2, C-terminal domain
    pfam01602
    Location:29 → 591
    Adaptin_N; Adaptin N terminal region

  4. XM_031899970.1 → XP_031755830.1  AP-2 complex subunit alpha-2 isoform X1

    UniProtKB/TrEMBL
    A0A6I8Q386, A0A8J1JFN0
    Conserved Domains (4) summary
    smart00809
    Location:789 → 892
    Alpha_adaptinC2; Adaptin C-terminal domain
    sd00044
    Location:332 → 355
    HEAT; HEAT repeat [structural motif]
    pfam02296
    Location:898 → 1006
    Alpha_adaptin_C; Alpha adaptin AP2, C-terminal domain
    pfam01602
    Location:29 → 591
    Adaptin_N; Adaptin N terminal region
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.