SRY sex determining region Y [Sus scrofa (pig)] - Gene

Summary

Gene symbol: SRY
Gene description: sex determining region Y
See related: Ensembl:ENSSSCG00000057000
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as: TDF
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Genomic context

Location:: chromosome: Y

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	Y	NC_010462.3 (40484990..40485700, complement)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	Y	NC_010462.2 (279587..280297, complement)

Chromosome Y - NC_010462.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Knockout of the HMG domain of the porcine SRY gene causes sex reversal in gene-edited pigs.
Title: Knockout of the HMG domain of the porcine SRY gene causes sex reversal in gene-edited pigs.
New insights into SRY regulation through identification of 5' conserved sequence are reported.
Title: New insights into SRY regulation through identification of 5' conserved sequences.
The 4.6 Kb of pig SRY 5' flanking sequences supported reporter transgene expression within the male genital ridge but not within the neural crest.
Title: Human and pig SRY 5' flanking sequences can direct reporter transgene expression to the genital ridge and to migrating neural crest cells.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in anatomical structure morphogenesis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in male sex determination	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: sex-determining region Y protein

Names: testis-determining factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_214452.3 → NP_999617.2 sex-determining region Y protein

See identical proteins and their annotated locations for NP_999617.2

Status: PROVISIONAL

Source sequence(s)

U49860

UniProtKB/Swiss-Prot

P36393

UniProtKB/TrEMBL

E5D4S2, E5D4W8, Q5I907, Q5I912, Q5I913, Q5I914, Q5I918, Q5I925, Q5I926

Related

ENSSSCP00000025359.2, ENSSSCT00000030781.2

Conserved Domains (1) summary

cd01388
Location:61 → 132

SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...