MIR205 microRNA 205 [Homo sapiens (human)] - Gene

Summary

Official Symbol: MIR205provided by HGNC
Official Full Name: microRNA 205provided by HGNC
Primary source: HGNC:HGNC:31583
See related: Ensembl:ENSG00000284485 MIM:613147; miRBase:MI0000285; AllianceGenome:HGNC:31583
Gene type: ncRNA
RefSeq status: PROVISIONAL
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MIRN205; mir-205
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

Location:: 1q32.2

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (209432133..209432242)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (208678941..208679050)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (209605478..209605587)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

microRNA-205 represses breast cancer metastasis by perturbing the rab coupling protein [RCP]-mediated integrin beta1 recycling on the membrane.
Title: microRNA-205 represses breast cancer metastasis by perturbing the rab coupling protein [RCP]-mediated integrin β1 recycling on the membrane.
Overexpression of microRNA-205-5p promotes cholangiocarcinoma growth by reducing expression of homeodomain-interacting protein kinase 3.
Title: Overexpression of microRNA-205-5p promotes cholangiocarcinoma growth by reducing expression of homeodomain-interacting protein kinase 3.
Exosomal miR-205-5p Improves Endometrial Receptivity by Upregulating E-Cadherin Expression through ZEB1 Inhibition.
Title: Exosomal miR-205-5p Improves Endometrial Receptivity by Upregulating E-Cadherin Expression through ZEB1 Inhibition.
MiR-205-3p suppresses bladder cancer progression via GLO1 mediated P38/ERK activation.
Title: MiR-205-3p suppresses bladder cancer progression via GLO1 mediated P38/ERK activation.
Micronome Revealed miR-205-5p as Key Regulator of VEGFA During Cancer Related Angiogenesis in Hepatocellular Carcinoma.
Title: Micronome Revealed miR-205-5p as Key Regulator of VEGFA During Cancer Related Angiogenesis in Hepatocellular Carcinoma.
Interactive role of miR-29, miR-93, miR-205, and VEGF in salivary adenoid cystic carcinoma.
Title: Interactive role of miR-29, miR-93, miR-205, and VEGF in salivary adenoid cystic carcinoma.
The LINC00152/miR-205-5p/CXCL11 axis in hepatocellular carcinoma cancer-associated fibroblasts affects cancer cell phenotypes and tumor growth.
Title: The LINC00152/miR-205-5p/CXCL11 axis in hepatocellular carcinoma cancer-associated fibroblasts affects cancer cell phenotypes and tumor growth.
microRNA-205 in prostate cancer: Overview to clinical translation.
Title: microRNA-205 in prostate cancer: Overview to clinical translation.
Regulation of antitumor miR-205 targets oncogenes: Direct regulation of lymphoid specific helicase and its clinical significance.
Title: Regulation of antitumor miR-205 targets oncogenes: Direct regulation of lymphoid specific helicase and its clinical significance.
miR-145, miR-205 and miR-451: potential tumor suppressors involved in the progression of in situ to invasive carcinoma of the breast.
Title: miR-145, miR-205 and miR-451: potential tumor suppressors involved in the progression of in situ to invasive carcinoma of the breast.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH68246 (e-PCR)
- UniSTS:34362

A006A02 (e-PCR)
- UniSTS:406

G20640 (e-PCR)
- UniSTS:407

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables mRNA 3'-UTR binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA base-pairing translational repressor activity	IDA Inferred from Direct Assay more info	PubMed
enables mRNA base-pairing translational repressor activity	IGI Inferred from Genetic Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in miRNA-mediated gene silencing by inhibition of translation	IDA Inferred from Direct Assay more info	PubMed
involved_in miRNA-mediated post-transcriptional gene silencing	HDA more info	PubMed
involved_in miRNA-mediated post-transcriptional gene silencing	IDA Inferred from Direct Assay more info	PubMed
involved_in miRNA-mediated post-transcriptional gene silencing	IEA Inferred from Electronic Annotation more info
acts_upstream_of negative regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of negative regulation of SMAD protein signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of negative regulation of SMAD protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of negative regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of negative regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of negative regulation of cell migration involved in sprouting angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of negative regulation of endothelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of fibroblast growth factor production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of negative regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of inflammatory response	IC Inferred by Curator more info	PubMed
acts_upstream_of negative regulation of osteoblast differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of negative regulation of receptor-mediated endocytosis	IC Inferred by Curator more info	PubMed
involved_in negative regulation of vascular endothelial growth factor production	HMP more info	PubMed
involved_in negative regulation of vascular endothelial growth factor production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of positive regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of metalloendopeptidase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of aorta morphogenesis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of RISC complex	IEA Inferred from Electronic Annotation more info
located_in extracellular space	HDA more info	PubMed

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.