MIR145 microRNA 145 [Homo sapiens (human)] - Gene

Summary

Official Symbol: MIR145provided by HGNC
Official Full Name: microRNA 145provided by HGNC
Primary source: HGNC:HGNC:31532
See related: Ensembl:ENSG00000276365 MIM:611795; miRBase:MI0000461; AllianceGenome:HGNC:31532
Gene type: ncRNA
RefSeq status: PROVISIONAL
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MIRN145; miR-145; miRNA145
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

Location:: 5q32

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	5	NC_000005.10 (149430646..149430733)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	5	NC_060929.1 (149965492..149965579)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	5	NC_000005.9 (148810209..148810296)

Chromosome 5 - NC_000005.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Resistance to gemcitabine is mediated by the circ_0036627/miR-145/S100A16 axis in pancreatic cancer.
Title: Resistance to gemcitabine is mediated by the circ_0036627/miR-145/S100A16 axis in pancreatic cancer.
MicroRNA miR-145-5p Inhibits Cutaneous Wound Healing by Targeting PDGFD in Diabetic Foot Ulcer.
Title: MicroRNA miR-145-5p Inhibits Cutaneous Wound Healing by Targeting PDGFD in Diabetic Foot Ulcer.
Loss of miR-145 promotes remyelination and functional recovery in a model of chronic central demyelination.
Title: Loss of miR-145 promotes remyelination and functional recovery in a model of chronic central demyelination.
Circ_0008571 modulates the phenotype of vascular smooth muscle cells by targeting miR-145-5p in intracranial aneurysms.
Title: Circ_0008571 modulates the phenotype of vascular smooth muscle cells by targeting miR-145-5p in intracranial aneurysms.
High microRNA-145 plasma levels are associated with decreased risk of future incident venous thromboembolism: the HUNT study.
Title: High microRNA-145 plasma levels are associated with decreased risk of future incident venous thromboembolism: the HUNT study.
CircCPA4 induces ASCT2 expression to promote tumor property of non-small cell lung cancer cells in a miR-145-5p-dependent manner.
Title: CircCPA4 induces ASCT2 expression to promote tumor property of non-small cell lung cancer cells in a miR-145-5p-dependent manner.
Differential Expression of MicroRNA MiR-145 and MiR-155 Downstream Targets in Oral Cancers Exhibiting Limited Chemotherapy Resistance.
Title: Differential Expression of MicroRNA MiR-145 and MiR-155 Downstream Targets in Oral Cancers Exhibiting Limited Chemotherapy Resistance.
Long noncoding RNA XIST inhibition promotes Leydig cell apoptosis by acting as a competing endogenous RNA for microRNA-145a-5p that targets SIRT1 in late-onset hypogonadism.
Title: Long noncoding RNA XIST inhibition promotes Leydig cell apoptosis by acting as a competing endogenous RNA for microRNA-145a-5p that targets SIRT1 in late-onset hypogonadism.
MiR-145 Alleviates Sepsis-Induced Inflammatory Responses and Organ Injury by Targeting ADAM17.
Title: MiR-145 Alleviates Sepsis-Induced Inflammatory Responses and Organ Injury by Targeting ADAM17.
Over-expression of microRNA-145 Elevating Autophagy Activities via Downregulating FRS2 Expression.
Title: Over-expression of microRNA-145 Elevating Autophagy Activities via Downregulating FRS2 Expression.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables mRNA 3'-UTR binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA base-pairing translational repressor activity	IDA Inferred from Direct Assay more info	PubMed
enables mRNA base-pairing translational repressor activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in angiotensin-activated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in aorta smooth muscle tissue morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in ectodermal cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in establishment or maintenance of cell type involved in phenotypic switching	ISS Inferred from Sequence or Structural Similarity more info
involved_in mesodermal cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in miRNA-mediated gene silencing by inhibition of translation	IDA Inferred from Direct Assay more info	PubMed
involved_in miRNA-mediated gene silencing by mRNA destabilization	IDA Inferred from Direct Assay more info	PubMed
involved_in miRNA-mediated gene silencing by mRNA destabilization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in miRNA-mediated post-transcriptional gene silencing	IDA Inferred from Direct Assay more info	PubMed
involved_in miRNA-mediated post-transcriptional gene silencing	IEA Inferred from Electronic Annotation more info
involved_in myofibroblast differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of SMAD protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of angiogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cardiac muscle cell apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cardiac muscle cell apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cardiac muscle hypertrophy	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of negative regulation of cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cellular response to transforming growth factor beta stimulus	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of cholesterol efflux	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of negative regulation of epithelial to mesenchymal transition	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of negative regulation of extracellular matrix assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of extracellular matrix assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of negative regulation of inflammatory response	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of interleukin-16 production	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of smooth muscle cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of somatic stem cell division	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of somatic stem cell population maintenance	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transforming growth factor beta receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of vascular associated smooth muscle cell dedifferentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of canonical Wnt signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cardiac vascular smooth muscle cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of cellular response to hypoxia	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of fibroblast migration	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of positive regulation of interleukin-10 production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of positive regulation of macrophage activation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of positive regulation of macrophage differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of collagen biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of phenotypic switching	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of smooth muscle contraction	ISS Inferred from Sequence or Structural Similarity more info
involved_in vascular associated smooth muscle cell differentiation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of RISC complex	IEA Inferred from Electronic Annotation more info
located_in extracellular exosome	IDA Inferred from Direct Assay more info	PubMed

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.