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dnaja2a DnaJ heat shock protein family (Hsp40) member A2a [ Danio rerio (zebrafish) ]

Gene ID: 406814, updated on 2-Nov-2024

Summary

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Official Symbol
dnaja2aprovided by ZNC
Official Full Name
DnaJ heat shock protein family (Hsp40) member A2aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-2884
See related
Ensembl:ENSDARG00000104066 AllianceGenome:ZFIN:ZDB-GENE-040426-2884
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
dnaja2; zgc:55486; zgc:85775; wu:fb59e04; wu:fb60b08
Summary
Predicted to enable protein-folding chaperone binding activity. Predicted to be involved in protein refolding. Predicted to act upstream of or within protein folding and response to heat. Predicted to be located in membrane. Predicted to be active in cytosol. Is expressed in brain; neurons; and proliferative region. Orthologous to human DNAJA2 (DnaJ heat shock protein family (Hsp40) member A2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See dnaja2a in Genome Data Viewer
Location:
chromosome: 7
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (41903543..41916505, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (41623470..41635239, complement)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene zgc:92818 Neighboring gene glutamic pyruvate transaminase (alanine aminotransferase) 2 Neighboring gene afadin- and alpha-actinin-binding protein-like Neighboring gene neuropilin and tolloid like 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Transcripts of Kv7.1 and MinK channels and slow delayed rectifier K(+) current (I(Ks)) are expressed in zebrafish (Danio rerio) heart. Abramochkin DV, et al. Pflugers Arch, 2018 Dec. PMID 30116893
  2. Transcript expression of inward rectifier potassium channels of Kir2 subfamily in Arctic marine and freshwater fish species. Hassinen M, et al. J Comp Physiol B, 2019 Dec. PMID 31679058
  3. Cardiac voltage-gated sodium channel expression and electrophysiological characterization of the sodium current in the zebrafish (Danio rerio) ventricle. Haverinen J, et al. Prog Biophys Mol Biol, 2018 Oct. PMID 29655910
  4. Expression of calcium channel transcripts in the zebrafish heart: dominance of T-type channels. Haverinen J, et al. J Exp Biol, 2018 May 20. PMID 29739832
  5. Eye-specific gene expression following embryonic ethanol exposure in zebrafish: roles for heat shock factor 1. Kashyap B, et al. Reprod Toxicol, 2014 Jan. PMID 24355176, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables Hsp70 protein binding IEA
Inferred from Electronic Annotation
more info
  
enables heat shock protein binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein-folding chaperone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables unfolded protein binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within protein folding IEA
Inferred from Electronic Annotation
more info
  
involved_in protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within response to heat IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
dnaJ homolog subfamily A member 2a
Names
DnaJ (Hsp40) homolog, subfamily A, member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213493.1 → NP_998658.1  dnaJ homolog subfamily A member 2a

    See identical proteins and their annotated locations for NP_998658.1

    Status: PROVISIONAL

    Source sequence(s)
    BC048042
    UniProtKB/TrEMBL
    A0A2R8RZG9, B2GT81, Q7ZUP5
    Related
    ENSDARP00000156655.1, ENSDART00000185785.1
    Conserved Domains (4) summary
    cd10719
    Location:144 → 210
    DnaJ_zf; Zinc finger domain of DnaJ and HSP40
    cd10747
    Location:115 → 341
    DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
    PTZ00037
    Location:4 → 412
    PTZ00037; DnaJ_C chaperone protein; Provisional
    pfam00226
    Location:9 → 67
    DnaJ; DnaJ domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    41903543..41916505 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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