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Vha26 Vacuolar H[+]-ATPase 26kD subunit [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40679, updated on 18-Sep-2024

Summary

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Official Symbol
Vha26provided by FlyBase
Official Full Name
Vacuolar H[+]-ATPase 26kD subunitprovided by FlyBase
Primary source
FLYBASE:FBgn0283535
Locus tag
Dmel_CG1088
See related
AllianceGenome:FB:FBgn0283535
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-83Bb; ATP6V1E1; BcDNA.GH03683; BcDNA:GH03683; CG1088; chr3R:1419698..1419836; Dmel\CG1088; oak-gall; okg; vATPase; vha26; VhaE
Summary
Predicted to enable proton-transporting ATPase activity, rotational mechanism. Involved in apical protein localization and terminal branching, open tracheal system. Located in plasma membrane. Part of plasma membrane proton-transporting V-type ATPase complex. Is expressed in several structures, including adult Malpighian tubule; adult heart; germ layer derivative; gut section; and reproductive system. Human ortholog(s) of this gene implicated in autosomal recessive cutis laxa type IIC. Orthologous to human ATP6V1E1 (ATPase H+ transporting V1 subunit E1) and ATP6V1E2 (ATPase H+ transporting V1 subunit E2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See Vha26 in Genome Data Viewer
Location:
83B4-83B4; 3-47.5 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (5591763..5595356)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (1417485..1421078)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene small Cajal body-specific RNA : MeU4:25F-C137 Neighboring gene DNA polymerase zeta subunit 2 Neighboring gene noisette Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene krasavietz

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterisation of vha26, the Drosophila gene for a 26 kDa E-subunit of the vacuolar ATPase. Guo Y, et al. Biochim Biophys Acta, 1996 Aug 14. PMID 8765087
  2. Natural resistance-associated macrophage protein is a cellular receptor for sindbis virus in both insect and mammalian hosts. Rose PP, et al. Cell Host Microbe, 2011 Aug 18. PMID 21843867, Free PMC Article
  3. Engineered Flock House Virus for Targeted Gene Suppression Through RNAi in Fruit Flies (Drosophila melanogaster) in Vitro and in Vivo. Taning CNT, et al. Front Physiol, 2018. PMID 30018564, Free PMC Article
  4. Ingested double-stranded RNAs can act as species-specific insecticides. Whyard S, et al. Insect Biochem Mol Biol, 2009 Nov. PMID 19815067
  5. Clinical-grade Garcinia cambogia extract dissolves calcium oxalate crystals in Drosophila kidney stone models. Fan QX, et al. Eur Rev Med Pharmacol Sci, 2020 Jun. PMID 32572941

See all (90) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables proton-transporting ATPase activity, rotational mechanism IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to proton-transporting ATPase activity, rotational mechanism IC
Inferred by Curator
more info
 PubMed 
enables proton-transporting ATPase activity, rotational mechanism IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in apical protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in liquid clearance, open tracheal system HMP PubMed 
involved_in proton transmembrane transport IC
Inferred by Curator
more info
 PubMed 
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in terminal branching, open tracheal system HMP PubMed 
involved_in terminal branching, open tracheal system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane HDA PubMed 
part_of plasma membrane proton-transporting V-type ATPase complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
part_of proton-transporting two-sector ATPase complex, catalytic domain IEA
Inferred from Electronic Annotation
more info
  
part_of vacuolar proton-transporting V-type ATPase, V1 domain ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
vacuolar H[+]-ATPase 26kD subunit
Names
CG1088-PA
CG1088-PB
CG1088-PC
E subunit
Vha26-PA
Vha26-PB
Vha26-PC
oak gall
vacuolar ATP synthase subunit E
vacuolar H+ATPase subunit E
vacuolar H[+]-ATPase 26 kD E subunit
vacuolar H[+]-ATPase 26kD E subunit

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    5591763..5595356
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001300253.1 → NP_001287182.1  vacuolar H[+]-ATPase 26kD subunit, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287182.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P54611, Q0KIB6, Q9V3K4
    UniProtKB/TrEMBL
    A0A0B4LGS4
    Conserved Domains (2) summary
    COG1390
    Location:9 → 217
    NtpE; Archaeal/vacuolar-type H+-ATPase subunit E/Vma4 [Energy production and conversion]
    pfam01991
    Location:18 → 216
    vATP-synt_E; ATP synthase (E/31 kDa) subunit

  2. NM_169073.2 → NP_730957.1  vacuolar H[+]-ATPase 26kD subunit, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730957.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P54611, Q0KIB6, Q9V3K4
    UniProtKB/TrEMBL
    A0A0B4LGS4
    Related
    FBpp0078350
    Conserved Domains (2) summary
    COG1390
    Location:9 → 217
    NtpE; Archaeal/vacuolar-type H+-ATPase subunit E/Vma4 [Energy production and conversion]
    pfam01991
    Location:18 → 216
    vATP-synt_E; ATP synthase (E/31 kDa) subunit

  3. NM_079513.3 → NP_524237.1  vacuolar H[+]-ATPase 26kD subunit, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524237.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P54611, Q0KIB6, Q9V3K4
    UniProtKB/TrEMBL
    A0A0B4LGS4
    Related
    FBpp0078349
    Conserved Domains (2) summary
    COG1390
    Location:9 → 217
    NtpE; Archaeal/vacuolar-type H+-ATPase subunit E/Vma4 [Energy production and conversion]
    pfam01991
    Location:18 → 216
    vATP-synt_E; ATP synthase (E/31 kDa) subunit
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4LGS4 A0A0B4LGS4
P54611.1 P54611

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