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pla2g12b phospholipase A2, group XIIB [ Danio rerio (zebrafish) ]

Gene ID: 406739, updated on 18-Sep-2024

Summary

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Official Symbol
pla2g12bprovided by ZNC
Official Full Name
phospholipase A2, group XIIBprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-2771
See related
Ensembl:ENSDARG00000015662 AllianceGenome:ZFIN:ZDB-GENE-040426-2771
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:56487; zgc:77746; wu:fb26d02; wu:fb99g06; wu:fc91d12; zgc:111897
Summary
Predicted to enable calcium ion binding activity and phospholipase A2 activity. Predicted to be involved in cholesterol homeostasis and triglyceride homeostasis. Predicted to act upstream of or within arachidonic acid secretion; lipid catabolic process; and phospholipid metabolic process. Predicted to be located in extracellular region. Is expressed in caudal fin skeleton and yolk syncytial layer. Orthologous to human PLA2G12B (phospholipase A2 group XIIB). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See pla2g12b in Genome Data Viewer
Location:
chromosome: 13
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (4671737..4683141)
105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (4543108..4554563)

Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137487356 Neighboring gene phosphodiesterase 10A Neighboring gene C1D nuclear receptor corepressor Neighboring gene oncoprotein induced transcript 3 Neighboring gene mitochondrial calcium uniporter

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Starvation causes changes in the intestinal transcriptome and microbiome that are reversed upon refeeding. Jawahar J, et al. BMC Genomics, 2022 Mar 22. PMID 35317738, Free PMC Article
  2. The LipoGlo reporter system for sensitive and specific monitoring of atherogenic lipoproteins. Thierer JH, et al. Nat Commun, 2019 Jul 31. PMID 31366908, Free PMC Article
  3. mRNA processing in mutant zebrafish lines generated by chemical and CRISPR-mediated mutagenesis produces unexpected transcripts that escape nonsense-mediated decay. Anderson JL, et al. PLoS Genet, 2017 Nov. PMID 29161261, Free PMC Article
  4. Proteomics analysis of the zebrafish skeletal extracellular matrix. Kessels MY, et al. PLoS One, 2014. PMID 24608635, Free PMC Article
  5. Enhanced transcription of complement and coagulation genes in the absence of adaptive immunity. Jima DD, et al. Mol Immunol, 2009 Apr. PMID 19200601, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC111897

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phospholipase A2 activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within arachidonate secretion IEA
Inferred from Electronic Annotation
more info
  
involved_in cholesterol homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phospholipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in triglyceride homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
group XIIB secretory phospholipase A2-like protein
NP_998595.2
XP_005156576.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213430.1 → NP_998595.2  group XIIB secretory phospholipase A2-like protein precursor

    See identical proteins and their annotated locations for NP_998595.2

    Status: PROVISIONAL

    Source sequence(s)
    BC052113
    UniProtKB/TrEMBL
    Q6P033
    Related
    ENSDARP00000130123.1, ENSDART00000164617.2
    Conserved Domains (1) summary
    pfam06951
    Location:68 → 231
    PLA2G12; Group XII secretory phospholipase A2 precursor (PLA2G12)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007124.7 Reference GRCz11 Primary Assembly

    Range
    4671737..4683141
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005156519.5 → XP_005156576.1  group XIIB secretory phospholipase A2-like protein isoform X1

    UniProtKB/TrEMBL
    A0A8M2B2K0, F1R147
    Related
    ENSDARP00000104679.1, ENSDART00000128494.3
    Conserved Domains (1) summary
    pfam06951
    Location:68 → 235
    PLA2G12; Group XII secretory phospholipase A2 precursor (PLA2G12)
Nucleotide Protein Strain
Heading Accession and Version

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