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Pi4KIIalpha Phosphatidylinositol 4-kinase II alpha [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40670, updated on 18-Sep-2024

Summary

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Official Symbol
Pi4KIIalphaprovided by FlyBase
Official Full Name
Phosphatidylinositol 4-kinase II alphaprovided by FlyBase
Primary source
FLYBASE:FBgn0037339
Locus tag
Dmel_CG2929
See related
AllianceGenome:FB:FBgn0037339
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG2929; Dmel\CG2929; Pi4KII; PI4KII; Pi4KIIa; PI4KIIa; PI4KIIA; PI4KIIalpha; PI4KIIbeta
Summary
Enables 1-phosphatidylinositol 4-kinase activity. Involved in several processes, including phosphatidylinositol phosphate biosynthetic process; secretory granule localization; and vesicle organization. Located in late endosome membrane and trans-Golgi network. Is expressed in embryonic/larval salivary gland and organism. Orthologous to human PI4K2A (phosphatidylinositol 4-kinase type 2 alpha) and PI4K2B (phosphatidylinositol 4-kinase type 2 beta). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See Pi4KIIalpha in Genome Data Viewer
Location:
83B1-83B2; 3-47.5 cM
Exon count:
12
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (5557663..5563652, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (1383385..1389374, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene meiosis I arrest Neighboring gene Protein-L-isoaspartate (D-aspartate) O-methyltransferase Neighboring gene Snm1 Neighboring gene ncRNA Neighboring gene antisense RNA:CR46136 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Type II phosphatidylinositol 4-kinase regulates nerve terminal growth and synaptic vesicle recycling. Cantarutti KC, et al. J Neurogenet, 2018 Sep. PMID 30175671
  2. Analysis of the catalytic domain of phosphatidylinositol 4-kinase type II. Barylko B, et al. J Biol Chem, 2002 Nov 15. PMID 12215430
  3. Vibrator and PI4KIIIα govern neuroblast polarity by anchoring non-muscle myosin II. Koe CT, et al. Elife, 2018 Feb 27. PMID 29482721, Free PMC Article
  4. The phosphoinositide phosphatase Sac1 regulates cell shape and microtubule stability in the developing Drosophila eye. Del Bel LM, et al. Development, 2018 May 31. PMID 29752385, Free PMC Article
  5. Developmental program-independent secretory granule degradation in larval salivary gland cells of Drosophila. Csizmadia T, et al. Traffic, 2022 Dec. PMID 36353974, Free PMC Article

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PI4KII is required for synaptic vesicles (SVs) endocytosis but dispensable for SV exocytosis
    Title: Type II phosphatidylinositol 4-kinase regulates nerve terminal growth and synaptic vesicle recycling.
  2. In PI4KII mutants, mucin-containing glue granules failed to reach normal size, with glue protein aberrantly accumulating in enlarged Rab7-positive late endosomes.
    Title: Type II phosphatidylinositol 4-kinase regulates trafficking of secretory granule proteins in Drosophila.
  3. expressed and characterized Drosophila PI4KII and its catalytic domain
    Title: Analysis of the catalytic domain of phosphatidylinositol 4-kinase type II.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables 1-phosphatidylinositol 4-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 1-phosphatidylinositol 4-kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 1-phosphatidylinositol 4-kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Golgi organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Golgi organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endosome organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endosome organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phosphatidylinositol phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylinositol phosphate biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein localization to organelle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in secretory granule localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in secretory granule organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in late endosome membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in trans-Golgi network IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
phosphatidylinositol 4-kinase II alpha
Names
CG2929-PA
CG2929-PB
CG2929-PC
CG2929-PE
CG2929-PF
Pi4KIIalpha-PA
Pi4KIIalpha-PB
Pi4KIIalpha-PC
Pi4KIIalpha-PE
Pi4KIIalpha-PF
NP_001368956.1
NP_001368992.1
NP_730944.2
NP_730945.1
NP_996154.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    5557663..5563652 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_206432.3 → NP_996154.1  phosphatidylinositol 4-kinase II alpha, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996154.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MZH2, Q8STF7, Q9VND3
    Conserved Domains (1) summary
    cl21453
    Location:293 → 474
    PKc_like; Protein Kinases, catalytic domain

  2. NM_169063.4 → NP_730944.2  phosphatidylinositol 4-kinase II alpha, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730944.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MZH2, Q8STF7, Q9VND3
    Related
    FBpp0089178
    Conserved Domains (1) summary
    cl21453
    Location:293 → 474
    PKc_like; Protein Kinases, catalytic domain

  3. NM_169064.2 → NP_730945.1  phosphatidylinositol 4-kinase II alpha, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730945.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8I0B7
    Related
    FBpp0078404
    Conserved Domains (1) summary
    cl21453
    Location:146 → 327
    PKc_like; Protein Kinases, catalytic domain

  4. NM_001382052.1 → NP_001368956.1  phosphatidylinositol 4-kinase II alpha, isoform E [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A6F7SG83
    Conserved Domains (1) summary
    cl21453
    Location:62 → 244
    PKc_like; Protein Kinases, catalytic domain

  5. NM_001382053.1 → NP_001368992.1  phosphatidylinositol 4-kinase II alpha, isoform F [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A6H2EES5, D6W4K4
    Conserved Domains (1) summary
    cl21453
    Location:39 → 221
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A6F7SG83 A0A6F7SG83
A0A6H2EES5 A0A6H2EES5
Q8I0B7 Q8I0B7
Q8STF7 Q8STF7
Q9VND3 Q9VND3

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