msmo1 methylsterol monooxygenase 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: msmo1provided by ZNC
Official Full Name: methylsterol monooxygenase 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2670
See related: Ensembl:ENSDARG00000055876 AllianceGenome:ZFIN:ZDB-GENE-040426-2670
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: sc4mol; koliber; zgc:56437; wu:fb59g06; wu:fb66e06
Summary: Predicted to enable C-4 methylsterol oxidase activity. Acts upstream of or within cholesterol biosynthetic process and regulation of chondrocyte differentiation. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including head; hypural; integument; pleuroperitoneal region; and yolk syncytial layer. Used to study chondrodysplasia punctata. Orthologous to human MSMO1 (methylsterol monooxygenase 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (20916551..20928737, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (20223614..20235800, complement)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fb59g06.x1 (e-PCR)
- UniSTS:203353

fb66e06.x1 (e-PCR)
- UniSTS:187335

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables C-4 methylsterol oxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables C-4 methylsterol oxidase activity	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cholesterol biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lipid biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of chondrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within steroid biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within steroid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in sterol biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sterol biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: methylsterol monooxygenase 1

Names: C-4 methylsterol oxidase

NP_998518.1

EC 1.14.18.9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213353.1 → NP_998518.1 methylsterol monooxygenase 1

See identical proteins and their annotated locations for NP_998518.1

Status: PROVISIONAL

Source sequence(s)

BC050163

UniProtKB/Swiss-Prot

Q7ZW77

Related

ENSDARP00000072739.4, ENSDART00000078277.5

Conserved Domains (2) summary

COG3000
Location:60 → 274

ERG3; Sterol desaturase/sphingolipid hydroxylase, fatty acid hydroxylase superfamily [Lipid transport and metabolism]

pfam04116
Location:145 → 274

FA_hydroxylase; Fatty acid hydroxylase superfamily