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decr2 2,4-dienoyl CoA reductase 2, peroxisomal [ Danio rerio (zebrafish) ]

Gene ID: 406623, updated on 12-Sep-2024

Summary

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Official Symbol
decr2provided by ZNC
Official Full Name
2,4-dienoyl CoA reductase 2, peroxisomalprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-2612
See related
Ensembl:ENSDARG00000045257 AllianceGenome:ZFIN:ZDB-GENE-040426-2612
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:85626; zC153C20.5
Summary
Predicted to enable 2,4-dienoyl-CoA reductase (NADPH) activity. Predicted to act upstream of or within fatty acid metabolic process. Predicted to be located in peroxisome. Orthologous to human DECR2 (2,4-dienoyl-CoA reductase 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See decr2 in Genome Data Viewer
Location:
chromosome: 24
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (37709215..37721712)
105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (37821294..37833815)

Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene H3 histone, family 3D Neighboring gene chromosome 24 C7orf50 homolog Neighboring gene ubiquinol-cytochrome c reductase complex assembly factor 4 Neighboring gene RAB11 family interacting protein 3 (class II) Neighboring gene TEL2, telomere maintenance 2, homolog (S. cerevisiae)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Tributyltin promoted hepatic steatosis in zebrafish (Danio rerio) and the molecular pathogenesis involved. Zhang J, et al. Aquat Toxicol, 2016 Jan. PMID 26674369
  2. Overexpression of gankyrin induces liver steatosis in zebrafish (Danio rerio). Her GM, et al. Biochim Biophys Acta, 2011 Sep. PMID 21722753
  3. Insights Into the Peroxisomal Protein Inventory of Zebrafish. Kamoshita M, et al. Front Physiol, 2022. PMID 35295584, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables 2,4-dienoyl-CoA reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 2,4-dienoyl-CoA reductase (NADPH) activity IEA
Inferred from Electronic Annotation
more info
  
enables 2,4-dienoyl-CoA reductase (NADPH) activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within fatty acid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]
Names
2,4-dienoyl-CoA reductase 2
peroxisomal 2,4-dienoyl-CoA reductase
NP_998486.1
XP_005162937.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213321.1 → NP_998486.1  peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]

    See identical proteins and their annotated locations for NP_998486.1

    Status: PROVISIONAL

    Source sequence(s)
    BC068332
    UniProtKB/Swiss-Prot
    Q6NV34, Q7T004
    Related
    ENSDARP00000066557.4, ENSDART00000066558.5
    Conserved Domains (2) summary
    cd05369
    Location:33 → 280
    TER_DECR_SDR_a; Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR
    PRK07576
    Location:33 → 283
    PRK07576; short chain dehydrogenase; Provisional

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007135.7 Reference GRCz11 Primary Assembly

    Range
    37709215..37721712
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005162880.5 → XP_005162937.1  peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing] isoform X1

    UniProtKB/TrEMBL
    A0A8M2B9V8
    Conserved Domains (2) summary
    cd05369
    Location:33 → 280
    TER_DECR_SDR_a; Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR
    PRK07576
    Location:33 → 283
    PRK07576; short chain dehydrogenase; Provisional

RNA

  1. XR_002456607.2 RNA Sequence

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018395184.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    903..5835
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6NV34.1 GenPept UniProtKB/Swiss-Prot:Q6NV34

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