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lclat1 lysocardiolipin acyltransferase 1 [ Danio rerio (zebrafish) ]

Gene ID: 406554, updated on 2-Nov-2024

Summary

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Official Symbol
lclat1provided by ZNC
Official Full Name
lysocardiolipin acyltransferase 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-081211-2
See related
Ensembl:ENSDARG00000103320 AllianceGenome:ZFIN:ZDB-GENE-081211-2
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
lycat; lycat1; 1-AGPAT 8; zgc:77380; wu:fj17g04
Summary
Predicted to enable 1-acylglycerol-3-phosphate O-acyltransferase activity. Acts upstream of or within endothelial cell development and hemangioblast cell differentiation. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum. Is expressed in hematopoietic stem cell. Orthologous to human LCLAT1 (lysocardiolipin acyltransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See lclat1 in Genome Data Viewer
Location:
chromosome: 13
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (51956397..51963460)
105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (51747141..51754204)

Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene inositol polyphosphate-5-phosphatase A Neighboring gene zmp:0000000755 Neighboring gene LBH regulator of WNT signaling pathway Neighboring gene serum response factor b Neighboring gene mitochondrial ribosomal protein L2 Neighboring gene kinesin light chain 1b Neighboring gene protein tyrosine kinase 7b Neighboring gene solute carrier family 30 member 10 Neighboring gene kelch domain containing 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Mouse lysocardiolipin acyltransferase controls the development of hematopoietic and endothelial lineages during in vitro embryonic stem-cell differentiation. Wang C, et al. Blood, 2007 Nov 15. PMID 17675553, Free PMC Article
  2. A zebrafish orthologue (whnb) of the mouse nude gene is expressed in the epithelial compartment of the embryonic thymic rudiment. Schorpp M, et al. Mech Dev, 2002 Oct. PMID 12351184
  3. Endocardium is necessary for cardiomyocyte movement during heart tube assembly. Holtzman NG, et al. Development, 2007 Jun. PMID 17537802
  4. tbx20, a new vertebrate T-box gene expressed in the cranial motor neurons and developing cardiovascular structures in zebrafish. Ahn DG, et al. Mech Dev, 2000 Jul. PMID 10906473
  5. Myelopoiesis in the zebrafish, Danio rerio. Bennett CM, et al. Blood, 2001 Aug 1. PMID 11468162

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data indicate that lycat is the earliest known player in the generation of both endothelial and hematopoietic lineages.
    Title: An acyltransferase controls the generation of hematopoietic and endothelial lineages in zebrafish.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables 1-acylglycerol-3-phosphate O-acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables 1-acylglycerol-3-phosphate O-acyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in CDP-diacylglycerol biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within embryonic hemopoiesis IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within embryonic hemopoiesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within endothelial cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within hemangioblast cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylinositol acyl-chain remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phospholipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
lysocardiolipin acyltransferase 1
Names
1-AGP acyltransferase 8
1-acylglycerol-3-phosphate O-acyltransferase 8
acyl-CoA:lysocardiolipin acyltransferase 1
NP_998435.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213270.2 → NP_998435.1  lysocardiolipin acyltransferase 1

    See identical proteins and their annotated locations for NP_998435.1

    Status: VALIDATED

    Source sequence(s)
    FO203516
    UniProtKB/Swiss-Prot
    Q6NYV8
    Related
    ENSDARP00000138738.1, ENSDART00000161098.2
    Conserved Domains (2) summary
    cd07990
    Location:55 → 248
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
    pfam16076
    Location:233 → 283
    Acyltransf_C; Acyltransferase C-terminus

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007124.7 Reference GRCz11 Primary Assembly

    Range
    51956397..51963460
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6NYV8.1 GenPept UniProtKB/Swiss-Prot:Q6NYV8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.