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elmo1 engulfment and cell motility 1 (ced-12 homolog, C. elegans) [ Danio rerio (zebrafish) ]

Gene ID: 406364, updated on 2-Nov-2024

Summary

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Official Symbol
elmo1provided by ZNC
Official Full Name
engulfment and cell motility 1 (ced-12 homolog, C. elegans)provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-2069
See related
Ensembl:ENSDARG00000098753 AllianceGenome:ZFIN:ZDB-GENE-040426-2069
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:85612; im:7151147; wu:fq24e08
Summary
Predicted to enable SH3 domain binding activity. Acts upstream of or within cilium assembly; lymphangiogenesis; and positive regulation of angiogenesis. Predicted to be part of guanyl-nucleotide exchange factor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including blood vessel; immature eye; mesoderm; nervous system; and pronephric tubule. Orthologous to human ELMO1 (engulfment and cell motility 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See elmo1 in Genome Data Viewer
Location:
chromosome: 19
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (33887589..34063490, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (34300469..34476382, complement)

Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene OTU deubiquitinase 6B Neighboring gene peroxisomal biogenesis factor 1 Neighboring gene si:dkey-184p18.2 Neighboring gene RP9 pre-mRNA splicing factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. ELMO1 protects renal structure and ultrafiltration in kidney development and under diabetic conditions. Sharma KR, et al. Sci Rep, 2016 Nov 16. PMID 27849017, Free PMC Article
  2. Elmo1 function, linked to Rac1 activity, regulates peripheral neuronal numbers and myelination in zebrafish. Mikdache A, et al. Cell Mol Life Sci, 2020 Jan. PMID 31161284, Free PMC Article
  3. Comparative Morphological, Metabolic and Transcriptome Analyses in elmo1 (-/-) , elmo2 (-/-) , and elmo3 (-/-) Zebrafish Mutants Identified a Functional Non-Redundancy of the Elmo Proteins. Boger M, et al. Front Cell Dev Biol, 2022. PMID 35874819, Free PMC Article
  4. The Rac1 regulator ELMO1 controls vascular morphogenesis in zebrafish. Epting D, et al. Circ Res, 2010 Jul 9. PMID 20466982
  5. Apoptotic cells are cleared by directional migration and elmo1- dependent macrophage engulfment. van Ham TJ, et al. Curr Biol, 2012 May 8. PMID 22503503, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Elmo1 is expressed in the developing nervous system. Elmo1 regulates axonal wrapping in the Posterior Lateral Line nerve.
    Title: Elmo1 function, linked to Rac1 activity, regulates peripheral neuronal numbers and myelination in zebrafish.
  2. these results highlight ELMO1 as an important factor for glomerular protection and renal cell survival via decreasing apoptosis, especially under diabetic conditions.
    Title: ELMO1 protects renal structure and ultrafiltration in kidney development and under diabetic conditions.
  3. ELMO-DOCK1, a bipartite guanine nucleotide exchange factor complex for the small GTPase Rac1, and for the membrane-cytoskeletal linker Ezrin, regulates centriole/basal body migration, docking and spacing.
    Title: The Rac1 regulator ELMO controls basal body migration and docking in multiciliated cells through interaction with Ezrin.
  4. A novel signaling cascade is identified in which ELMO1/DOCK180 regulates vasculature formation in zebrafish.
    Title: The Rac1 regulator ELMO1 controls vascular morphogenesis in zebrafish.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables SH3 domain binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cell motility IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cilium assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within lymphangiogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within phagocytosis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of guanyl-nucleotide exchange factor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
engulfment and cell motility protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213091.1 → NP_998256.1  engulfment and cell motility protein 1

    See identical proteins and their annotated locations for NP_998256.1

    Status: PROVISIONAL

    Source sequence(s)
    BC068327
    UniProtKB/TrEMBL
    A0A8M3AL10, Q6NV39
    Related
    ENSDARP00000132398.1, ENSDART00000172618.2
    Conserved Domains (3) summary
    cd13359
    Location:545 → 674
    PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain
    pfam04727
    Location:305 → 475
    ELMO_CED12; ELMO/CED-12 family
    pfam11841
    Location:115 → 279
    DUF3361; Domain of unknown function (DUF3361)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007130.7 Reference GRCz11 Primary Assembly

    Range
    33887589..34063490 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009294313.4 → XP_009292588.1  engulfment and cell motility protein 1 isoform X4

    UniProtKB/TrEMBL
    A0A8M3ASM6
    Conserved Domains (3) summary
    cd13359
    Location:533 → 662
    PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain
    pfam04727
    Location:293 → 463
    ELMO_CED12; ELMO/CED-12 family
    pfam11841
    Location:115 → 267
    DUF3361; Domain of unknown function (DUF3361)

  2. XM_009294310.4 → XP_009292585.1  engulfment and cell motility protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A2R8RS12, A0A8M3B3L5
    Related
    ENSDARP00000151585.1, ENSDART00000183907.1
    Conserved Domains (3) summary
    cd13359
    Location:547 → 676
    PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain
    pfam04727
    Location:307 → 477
    ELMO_CED12; ELMO/CED-12 family
    pfam11841
    Location:115 → 281
    DUF3361; Domain of unknown function (DUF3361)

  3. XM_009294311.4 → XP_009292586.1  engulfment and cell motility protein 1 isoform X3

    See identical proteins and their annotated locations for XP_009292586.1

    UniProtKB/TrEMBL
    A0A8M3AL10, Q6NV39
    Conserved Domains (3) summary
    cd13359
    Location:545 → 674
    PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain
    pfam04727
    Location:305 → 475
    ELMO_CED12; ELMO/CED-12 family
    pfam11841
    Location:115 → 279
    DUF3361; Domain of unknown function (DUF3361)

  4. XM_009294308.4 → XP_009292583.1  engulfment and cell motility protein 1 isoform X1

    See identical proteins and their annotated locations for XP_009292583.1

    UniProtKB/TrEMBL
    A0A0R4IHP8, A0A8M3ASM3
    Related
    ENSDARP00000132947.1, ENSDART00000157815.2
    Conserved Domains (3) summary
    cd13359
    Location:559 → 688
    PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain
    pfam04727
    Location:319 → 489
    ELMO_CED12; ELMO/CED-12 family
    pfam11841
    Location:115 → 293
    DUF3361; Domain of unknown function (DUF3361)

  5. XM_068215107.1 → XP_068071208.1  engulfment and cell motility protein 1 isoform X3

  6. XM_068215106.1 → XP_068071207.1  engulfment and cell motility protein 1 isoform X1

  7. XM_009294309.4 → XP_009292584.1  engulfment and cell motility protein 1 isoform X1

    See identical proteins and their annotated locations for XP_009292584.1

    UniProtKB/TrEMBL
    A0A0R4IHP8, A0A8M3ASM3
    Conserved Domains (3) summary
    cd13359
    Location:559 → 688
    PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain
    pfam04727
    Location:319 → 489
    ELMO_CED12; ELMO/CED-12 family
    pfam11841
    Location:115 → 293
    DUF3361; Domain of unknown function (DUF3361)

  8. XM_009294312.4 → XP_009292587.1  engulfment and cell motility protein 1 isoform X5

    UniProtKB/TrEMBL
    A0A8M3AVM1
    Conserved Domains (1) summary
    cd13359
    Location:66 → 195
    PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain
Nucleotide Protein Strain
Heading Accession and Version

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