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klhl20 kelch-like family member 20 [ Danio rerio (zebrafish) ]

Gene ID: 406274, updated on 2-Nov-2024

Summary

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Official Symbol
klhl20provided by ZNC
Official Full Name
kelch-like family member 20provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1935
See related
Ensembl:ENSDARG00000038801 AllianceGenome:ZFIN:ZDB-GENE-040426-1935
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fc33f09; zgc:66288; wu:fc33f09
Summary
Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in telencephalon. Orthologous to human KLHL20 (kelch like family member 20). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See klhl20 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (34112115..34126879)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (34128882..34143661)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene patched 2 Neighboring gene eukaryotic translation initiation factor 2B, subunit 3 gamma Neighboring gene centromere protein L Neighboring gene aspartyl-tRNA synthetase 2, mitochondrial

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ubiquitin-like ligase-substrate adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Cul3-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
kelch-like protein 20
Names
kelch-like 20

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213001.1 → NP_998166.1  kelch-like protein 20

    See identical proteins and their annotated locations for NP_998166.1

    Status: PROVISIONAL

    Source sequence(s)
    BC057505
    UniProtKB/TrEMBL
    Q6PFL3
    Related
    ENSDARP00000122821.1, ENSDART00000146624.3
    Conserved Domains (5) summary
    smart00612
    Location:319 → 364
    Kelch; Kelch domain
    PHA03098
    Location:53 → 490
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:259 → 303
    Kelch; KELCH repeat [structural motif]
    pfam00651
    Location:41 → 144
    BTB; BTB/POZ domain
    cl06652
    Location:137 → 175
    BACK_like; BTB-And-C-terminal-Kelch (BACK) domain and similar domains

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    34112115..34126879
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005163492.5 → XP_005163549.1  kelch-like protein 20 isoform X1

    UniProtKB/TrEMBL
    A0A8M2BAT8, E9QC58
    Related
    ENSDARP00000056665.4, ENSDART00000056666.6
    Conserved Domains (3) summary
    PHA03098
    Location:45 → 568
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:337 → 381
    Kelch; KELCH repeat [structural motif]
    cd18249
    Location:27 → 154
    BTB_POZ_KLHL20_KLEIP; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20)
Nucleotide Protein
Heading Accession and Version

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