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pdcd4a programmed cell death 4a [ Danio rerio (zebrafish) ]

Gene ID: 406261, updated on 12-Sep-2024

Summary

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Official Symbol
pdcd4aprovided by ZNC
Official Full Name
programmed cell death 4aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1920
See related
Ensembl:ENSDARG00000021702 AllianceGenome:ZFIN:ZDB-GENE-040426-1920
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:66311; wu:fa55g03; wu:fb08a11; wu:fe01a02
Summary
Predicted to act upstream of or within negative regulation of transcription, DNA-templated. Predicted to be located in cytoplasm. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including head; immature eye; midbrain; neural plate; and segmental plate. Orthologous to human PDCD4 (programmed cell death 4). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See pdcd4a in Genome Data Viewer
Location:
chromosome: 1
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (26046146..26063181, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (25352432..25369479, complement)

Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137495493 Neighboring gene G patch domain and ankyrin repeats 1 Neighboring gene MAX dimerization protein 4 Neighboring gene NADH:ubiquinone oxidoreductase subunit B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Haemodynamically dependent valvulogenesis of zebrafish heart is mediated by flow-dependent expression of miR-21. Banjo T, et al. Nat Commun, 2013. PMID 23748970, Free PMC Article
  2. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
  3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
programmed cell death protein 4a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_212988.1 → NP_998153.1  programmed cell death protein 4a

    See identical proteins and their annotated locations for NP_998153.1

    Status: PROVISIONAL

    Source sequence(s)
    BC054680
    UniProtKB/TrEMBL
    Q7SYL0
    Related
    ENSDARP00000148546.1, ENSDART00000185348.1
    Conserved Domains (1) summary
    smart00544
    Location:328 → 431
    MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007112.7 Reference GRCz11 Primary Assembly

    Range
    26046146..26063181 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005159885.5 → XP_005159942.1  programmed cell death protein 4a isoform X1

    UniProtKB/TrEMBL
    A0A8M2B6S0, F1QBM2
    Related
    ENSDARP00000131636.1, ENSDART00000168640.2
    Conserved Domains (1) summary
    smart00544
    Location:328 → 431
    MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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