mnx2b motor neuron and pancreas homeobox 2b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mnx2bprovided by ZNC
Official Full Name: motor neuron and pancreas homeobox 2bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040415-2
See related: Ensembl:ENSDARG00000030350 AllianceGenome:ZFIN:ZDB-GENE-040415-2
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: mnr2b; hlxb9lb
Summary: Predicted to enable DNA-binding transcription factor activity. Acts upstream of or within spinal cord motor neuron cell fate specification. Predicted to be located in nucleus. Is expressed in several structures, including endodermal cell; lateral mesoderm; motor neurons; spinal cord; and spinal cord neural tube. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 1

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (5449777..5455502, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (4751972..4757697, complement)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

this study revealed a specific requirement of mnx2b in tubule morphogenesis.
Title: Pronephric tubule morphogenesis in zebrafish depends on Mnx mediated repression of irx1b within the intermediate mesoderm.
Displays homology to the related chicken mnr2.
Title: Zebrafish mnx genes in endocrine and exocrine pancreas formation.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within spinal cord motor neuron cell fate specification	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within spinal cord motor neuron cell fate specification	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: motor neuron and pancreas homeobox 2b

Names: homeo box HB9 like b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001009887.2 → NP_001009887.2 motor neuron and pancreas homeobox 2b isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains an alternate in-frame splice site in the 5' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.

Source sequence(s)

CR762428

UniProtKB/TrEMBL

A0A8N7UY36, A2CEW5

Related

ENSDARP00000040367.4, ENSDART00000040368.5
NM_001328358.1 → NP_001315287.1 motor neuron and pancreas homeobox 2b isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

CR762428

UniProtKB/TrEMBL

A0A8M1P904, F1RCJ6

Related

ENSDARP00000100110.2, ENSDART00000114035.4

Conserved Domains (1) summary

pfam00046
Location:165 → 218

Homeobox; Homeobox domain