laza lazaro [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: lazaprovided by FlyBase
Official Full Name: lazaroprovided by FlyBase
Primary source: FLYBASE:FBgn0037163
Locus tag: Dmel_CG11440
See related: AllianceGenome:FB:FBgn0037163
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG11440; Dmel\CG11440; Laza; LPP; LPP-like; WUN-like
Summary: Predicted to enable lipid phosphatase activity and phosphatidate phosphatase activity. Involved in phototransduction; response to light intensity; and thermotaxis. Predicted to be located in membrane. Predicted to be integral component of plasma membrane. Is expressed in embryonic/larval midgut interstitial cell; eye; and presumptive embryonic/larval digestive system. Orthologous to human PLPP1 (phospholipid phosphatase 1) and PLPP3 (phospholipid phosphatase 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (22458816..22461131, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (22451916..22454231, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

CG11440, referred to as Lazaro (Laza), functions in the convergence of both PLC- and PLD-coupled signaling in vivo.
Title: Dependence on the Lazaro phosphatidic acid phosphatase for the maximum light response.
lazaro (laza) encodes a lipid phosphate phosphohydrolase (LPP) that functions during phototransduction.
Title: lazaro encodes a lipid phosphate phosphohydrolase that regulates phosphatidylinositol turnover during Drosophila phototransduction.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables phosphatidate phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidate phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in phospholipid dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in phototransduction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in phototransduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to light intensity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in thermotaxis	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

NP_649391.1

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The following sections contain reference sequences that belong to a specific genome build. Explain