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pik3r2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) [ Danio rerio (zebrafish) ]

Gene ID: 404211, updated on 2-Nov-2024

Summary

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Official Symbol
pik3r2provided by ZNC
Official Full Name
phosphoinositide-3-kinase, regulatory subunit 2 (beta)provided by ZNC
Primary source
ZFIN:ZDB-GENE-040309-1
See related
Ensembl:ENSDARG00000018060 AllianceGenome:ZFIN:ZDB-GENE-040309-1
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable 1-phosphatidylinositol-3-kinase regulator activity. Predicted to be involved in insulin receptor signaling pathway. Predicted to act upstream of or within signal transduction. Predicted to be part of phosphatidylinositol 3-kinase complex, class IA. Is expressed in skeletal muscle. Human ortholog(s) of this gene implicated in pancreatic ductal adenocarcinoma. Orthologous to human PIK3R2 (phosphoinositide-3-kinase regulatory subunit 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See pik3r2 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (24693485..24755347)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (25037644..25095091)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene Growth differentiation factor-15 Neighboring gene microtubule associated serine/threonine kinase 3a Neighboring gene uncharacterized LOC101882114 Neighboring gene IFI30 lysosomal thiol reductase a Neighboring gene MPV17 mitochondrial inner membrane protein like 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Phosphoinositide 3-kinase is required for process outgrowth and cell polarization of gastrulating mesendodermal cells. Montero JA, et al. Curr Biol, 2003 Aug 5. PMID 12906787
  2. Altering PI3K-Akt signalling in zebrafish embryos affects PTEN phosphorylation and gastrulation. Finkielsztein A, et al. Biol Cell, 2009 Aug 25. PMID 19515017
  3. Role of the ADCY9 gene in cardiac abnormalities of the Rubinstein-Taybi syndrome. Wu Y, et al. Orphanet J Rare Dis, 2020 Apr 22. PMID 32321550, Free PMC Article
  4. Identification of mundoserone by zebrafish in vivo screening as a natural product with anti-angiogenic activity. Chen K, et al. Exp Ther Med, 2018 Dec. PMID 30542405, Free PMC Article
  5. In vivo Screening of Natural Products Against Angiogenesis and Mechanisms of Anti-Angiogenic Activity of Deoxysappanone B 7,4'-Dimethyl Ether. Chen K, et al. Drug Des Devel Ther, 2020. PMID 32801645, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables 1-phosphatidylinositol-3-kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in insulin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of phosphatidylinositol 3-kinase complex, class IA IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
phosphatidylinositol 3-kinase regulatory subunit beta
Names
phosphoinositide-3-kinase, regulatory subunit, polypeptide 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_212822.2 → NP_997987.2  phosphatidylinositol 3-kinase regulatory subunit beta

    See identical proteins and their annotated locations for NP_997987.2

    Status: VALIDATED

    Source sequence(s)
    CABZ01043807, CR769774, EB913392
    UniProtKB/TrEMBL
    A0A8M1PI32, B3DHG9
    Related
    ENSDARP00000130009.1, ENSDART00000170467.2
    Conserved Domains (6) summary
    cd09930
    Location:616 → 720
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:326 → 433
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cd11909
    Location:6 → 79
    SH3_PI3K_p85beta; Src Homology 3 domain of the p85beta regulatory subunit of Class IA Phosphatidylinositol 3-kinases
    cd12926
    Location:438 → 598
    iSH2_PIK3R2; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 2, PIK3R2, also called p85beta
    pfam16454
    Location:437 → 596
    PI3K_P85_iSH2; Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
    cl02570
    Location:113 → 298
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    24693485..24755347
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005163369.5 → XP_005163426.1  phosphatidylinositol 3-kinase regulatory subunit beta isoform X1

    See identical proteins and their annotated locations for XP_005163426.1

    UniProtKB/TrEMBL
    A0A8M1PI32, B3DHG9
    Related
    ENSDARP00000118451.2, ENSDART00000147207.3
    Conserved Domains (6) summary
    cd09930
    Location:616 → 720
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:326 → 433
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cd11909
    Location:6 → 79
    SH3_PI3K_p85beta; Src Homology 3 domain of the p85beta regulatory subunit of Class IA Phosphatidylinositol 3-kinases
    cd12926
    Location:438 → 598
    iSH2_PIK3R2; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 2, PIK3R2, also called p85beta
    pfam16454
    Location:437 → 596
    PI3K_P85_iSH2; Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
    cl02570
    Location:113 → 298
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...

  2. XM_005163370.5 → XP_005163427.1  phosphatidylinositol 3-kinase regulatory subunit beta isoform X1

    See identical proteins and their annotated locations for XP_005163427.1

    UniProtKB/TrEMBL
    A0A8M1PI32, B3DHG9
    Conserved Domains (6) summary
    cd09930
    Location:616 → 720
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:326 → 433
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cd11909
    Location:6 → 79
    SH3_PI3K_p85beta; Src Homology 3 domain of the p85beta regulatory subunit of Class IA Phosphatidylinositol 3-kinases
    cd12926
    Location:438 → 598
    iSH2_PIK3R2; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 2, PIK3R2, also called p85beta
    pfam16454
    Location:437 → 596
    PI3K_P85_iSH2; Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
    cl02570
    Location:113 → 298
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394504.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    118602..160324
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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