U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

crim1 cysteine rich transmembrane BMP regulator 1 (chordin-like) [ Danio rerio (zebrafish) ]

Gene ID: 404210, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
crim1provided by ZNC
Official Full Name
cysteine rich transmembrane BMP regulator 1 (chordin-like)provided by ZNC
Primary source
ZFIN:ZDB-GENE-040312-2
See related
Ensembl:ENSDARG00000029668 AllianceGenome:ZFIN:ZDB-GENE-040312-2
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
wu:fc29f08
Summary
Predicted to enable serine-type endopeptidase inhibitor activity. Acts upstream of or within blood vessel development; notochord morphogenesis; and somitogenesis. Predicted to be located in extracellular region and membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including axis; intermediate cell mass of mesoderm; notochord; otic vesicle; and posterior segment eye. Used to study cataract and microphthalmia. Orthologous to human CRIM1 (cysteine rich transmembrane BMP regulator 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See crim1 in Genome Data Viewer
Location:
chromosome: 17
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (38929275..39184408, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (38981690..39236823, complement)

Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene D-glutamate cyclase Neighboring gene solute carrier family 24 member 4a Neighboring gene zgc:174356 Neighboring gene small nucleolar RNA SNORA47 Neighboring gene glutamyl-prolyl-tRNA synthetase 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A High-Throughput Assay for Congenital and Age-Related Eye Diseases in Zebrafish. Brastrom LK, et al. Biomedicines, 2019 Apr 11. PMID 30979021, Free PMC Article
  2. Invertebrate hematopoiesis: an astakine-dependent novel hematopoietic factor. Lin X, et al. J Immunol, 2011 Feb 15. PMID 21220699
  3. Functional and evolutionary insights from the Ciona notochord transcriptome. Reeves WM, et al. Development, 2017 Sep 15. PMID 28928284, Free PMC Article
  4. Knockdown of zebrafish crim1 results in a bent tail phenotype with defects in somite and vascular development. Kinna G, et al. Mech Dev, 2006 Apr. PMID 16524703
  5. Non-nuclear Pool of Splicing Factor SFPQ Regulates Axonal Transcripts Required for Normal Motor Development. Thomas-Jinu S, et al. Neuron, 2017 Apr 19. PMID 28392072, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. primary role of zebrafish crim1 is likely to be the regulation of somitic and vascular development
    Title: Knockdown of zebrafish crim1 results in a bent tail phenotype with defects in somite and vascular development.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables enzyme inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within blood vessel development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within notochord morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within somitogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
cysteine-rich motor neuron 1 protein
Names
CRIM-1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_212821.1 → NP_997986.1  cysteine-rich motor neuron 1 protein precursor

    See identical proteins and their annotated locations for NP_997986.1

    Status: PROVISIONAL

    Source sequence(s)
    AY151045
    UniProtKB/Swiss-Prot
    Q7T3Q2
    Related
    ENSDARP00000050533.4, ENSDART00000050534.6
    Conserved Domains (4) summary
    smart00214
    Location:330 → 384
    VWC; von Willebrand factor (vWF) type C domain
    pfam00219
    Location:33 → 84
    IGFBP; Insulin-like growth factor binding protein
    pfam02822
    Location:561 → 586
    Antistasin; Antistasin family
    cl17735
    Location:812 → 866
    VWC; von Willebrand factor type C domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007128.7 Reference GRCz11 Primary Assembly

    Range
    38929275..39184408 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7T3Q2.1 GenPept UniProtKB/Swiss-Prot:Q7T3Q2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools