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SLC4A2 solute carrier family 4 member 2 [ Bos taurus (domestic cattle) ]

Gene ID: 404084, updated on 10-Oct-2024

Summary

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Official Symbol
SLC4A2provided by VGNC
Official Full Name
solute carrier family 4 member 2provided by VGNC
Primary source
VGNC:VGNC:34892
See related
BGD:BT22871; Ensembl:ENSBTAG00000011226
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See SLC4A2 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 4 NC_037331.1 (113636353..113651449)

Chromosome 4 - NC_037331.1Genomic Context describing neighboring genes Neighboring gene acid sensing ion channel subunit 3 Neighboring gene cyclin dependent kinase 5 Neighboring gene Fas activated serine/threonine kinase Neighboring gene microRNA mir-6525 Neighboring gene transmembrane and ubiquitin like domain containing 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037331.1 Chromosome 4 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A deletion mutation in bovine SLC4A2 is associated with osteopetrosis in Red Angus cattle. Meyers SN, et al. BMC Genomics, 2010 May 27. PMID 20507629, Free PMC Article
  2. The presence of NHE1 and NHE3 Na+-H+ exchangers and an apical cAMP-independent Cl- channel indicate that both absorptive and secretory functions are present in calf gall bladder epithelium. Bazzini C, et al. Exp Physiol, 2001 Sep. PMID 11571484
  3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results indicate that a deletion mutation within bovine SLC4A2 is associated with osteopetrosis in Red Angus cattle.
    Title: A deletion mutation in bovine SLC4A2 is associated with osteopetrosis in Red Angus cattle.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables monoatomic anion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables solute:inorganic anion antiporter activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in bicarbonate transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in monoatomic anion transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of intracellular pH IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
anion exchange protein 2
Names
SLC4A2 anion exchanger
chloride-bicarbonate exchanger
solute carrier family 4, anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001205664.3 → NP_001192593.1  anion exchange protein 2

    See identical proteins and their annotated locations for NP_001192593.1

    Status: PROVISIONAL

    Source sequence(s)
    NKLS02000004
    UniProtKB/TrEMBL
    A0A3Q1M051, F1N4L1
    Conserved Domains (3) summary
    TIGR00834
    Location:322 → 1238
    ae; anion exchange protein
    pfam00955
    Location:673 → 1166
    HCO3_cotransp; HCO3- transporter family
    pfam07565
    Location:357 → 618
    Band_3_cyto; Band 3 cytoplasmic domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037331.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    113636353..113651449
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005205793.4 → XP_005205850.1  anion exchange protein 2 isoform X1

    See identical proteins and their annotated locations for XP_005205850.1

    UniProtKB/TrEMBL
    A0A3Q1M051, F1N4L1
    Related
    ENSBTAP00000014910.6, ENSBTAT00000014910.7
    Conserved Domains (3) summary
    TIGR00834
    Location:322 → 1238
    ae; anion exchange protein
    pfam00955
    Location:673 → 1166
    HCO3_cotransp; HCO3- transporter family
    pfam07565
    Location:357 → 618
    Band_3_cyto; Band 3 cytoplasmic domain

  2. XM_059885417.1 → XP_059741400.1  anion exchange protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A3Q1M5F2
    Related
    ENSBTAP00000065129.2, ENSBTAT00000083376.2
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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