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S1P Site-1 protease [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40399, updated on 2-Nov-2024

Summary

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Official Symbol
S1Pprovided by FlyBase
Official Full Name
Site-1 proteaseprovided by FlyBase
Primary source
FLYBASE:FBgn0037105
Locus tag
Dmel_CG7169
See related
AllianceGenome:FB:FBgn0037105
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG7169; Dmel\CG7169; dS1P; SKI-1/S1P
Summary
Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in Golgi apparatus. Human ortholog(s) of this gene implicated in spondyloepiphyseal dysplasia Kondo-Fu type. Orthologous to human MBTPS1 (membrane bound transcription factor peptidase, site 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See S1P in Genome Data Viewer
Location:
78E1-78E1; 3-47 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (21613797..21617376, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (21606897..21610476, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43939 Neighboring gene hairpin RNA:CR46340 Neighboring gene Transcription factor AP-2 Neighboring gene long non-coding RNA:CR43940 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mechanism of Folding and Activation of Subtilisin Kexin Isozyme-1 (SKI-1)/Site-1 Protease (S1P). da Palma JR, et al. J Biol Chem, 2016 Jan 29. PMID 26645686, Free PMC Article
  2. The SREBP pathway--insights from Insigs and insects. Rawson RB. Nat Rev Mol Cell Biol, 2003 Aug. PMID 12923525
  3. Activation of sterol regulatory element-binding protein by the caspase Drice in Drosophila larvae. Amarneh B, et al. J Biol Chem, 2009 Apr 10. PMID 19224859, Free PMC Article
  4. The SREBP pathway in Drosophila: regulation by palmitate, not sterols. Seegmiller AC, et al. Dev Cell, 2002 Feb. PMID 11832248
  5. Transcriptional Feedback Links Lipid Synthesis to Synaptic Vesicle Pools in Drosophila Photoreceptors. Tsai JW, et al. Neuron, 2019 Feb 20. PMID 30737130, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Site-1 protease
Names
CG7169-PA
S1P-PA
subtilisin kexin isozyme-1/site-1 protease
NP_649337.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    21613797..21617376 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_141080.3 → NP_649337.2  Site-1 protease [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649337.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8N0B7, Q9VP10
    Related
    FBpp0078120
    Conserved Domains (3) summary
    cd07479
    Location:154 → 407
    Peptidases_S8_SKI-1_like; Peptidase S8 family domain in SKI-1-like proteins
    pfam00082
    Location:160 → 416
    Peptidase_S8; Subtilase family
    pfam14258
    Location:610 → 673
    DUF4350; Domain of unknown function (DUF4350)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VP10 Q9VP10

Gene LinkOut

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