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GALC galactosylceramidase [ Canis lupus familiaris (dog) ]

Gene ID: 403916, updated on 17-Aug-2024

Summary

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Official Symbol
GALCprovided by VGNC
Official Full Name
galactosylceramidaseprovided by VGNC
Primary source
VGNC:VGNC:41079
See related
Ensembl:ENSCAFG00845009690
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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See GALC in Genome Data Viewer
Location:
chromosome: 8
Exon count:
19
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 8 NC_051812.1 (59531522..59589663, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 8 NC_006590.4 (58846151..58903131, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 8 NC_049229.1 (59594667..59651690, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 8 NC_049268.1 (59214260..59271257, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 8 NC_049749.1 (59260650..59317658, complement)

Chromosome 8 - NC_051812.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111097239 Neighboring gene uncharacterized LOC119873017 Neighboring gene chromosome 9 open reading frame 78 ortholog pseudogene Neighboring gene uncharacterized LOC102154577 Neighboring gene uncharacterized LOC111097131

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Clinical, electrophysiological, and biochemical markers of peripheral and central nervous system disease in canine globoid cell leukodystrophy (Krabbe's disease). Bradbury AM, et al. J Neurosci Res, 2016 Nov. PMID 27638585, Free PMC Article
  2. Cloning of the canine GALC cDNA and identification of the mutation causing globoid cell leukodystrophy in West Highland White and Cairn terriers. Victoria T, et al. Genomics, 1996 May 1. PMID 8661004

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This study demonistrated that CNS and PNS disease progression can be quantified over time in the canine model of GLD with tools identical to those used to assess human patients.
    Title: Clinical, electrophysiological, and biochemical markers of peripheral and central nervous system disease in canine globoid cell leukodystrophy (Krabbe's disease).
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables galactosylceramidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in galactosylceramide catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
galactocerebrosidase
Names
GALCERase
casein kinase 2, beta polypeptide pseudogene
galactocerebroside beta-galactosidase
galactosylceramidase (Krabbe disease)
galactosylceramide beta-galactosidase
NP_001003238.1
XP_038528772.1
XP_038528773.1
XP_038528774.1
XP_038528775.1
XP_038528776.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003238.1 → NP_001003238.1  galactocerebrosidase precursor

    See identical proteins and their annotated locations for NP_001003238.1

    Status: PROVISIONAL

    Source sequence(s)
    L76184
    UniProtKB/Swiss-Prot
    P54804
    UniProtKB/TrEMBL
    A0A8C0Q4R5
    Related
    ENSCAFP00845013315.1, ENSCAFT00845017098.1
    Conserved Domains (2) summary
    pfam02057
    Location:51 → 333
    Glyco_hydro_59; Glycosyl hydrolase family 59
    pfam17387
    Location:341 → 456
    Glyco_hydro_59M; Glycosyl hydrolase family 59 central domain

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051812.1 Reference ROS_Cfam_1.0

    Range
    59531522..59589663 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038672845.1 → XP_038528773.1  galactocerebrosidase isoform X1

    UniProtKB/TrEMBL
    A0A8I3NF27, A0A8P0NLV4
    Conserved Domains (3) summary
    pfam02057
    Location:70 → 353
    Glyco_hydro_59; Glycosyl hydrolase family 59
    pfam17387
    Location:361 → 476
    Glyco_hydro_59M; Glycosyl hydrolase family 59 central domain
    cl02099
    Location:3 → 32
    CK_II_beta; Casein kinase II regulatory subunit

  2. XM_038672847.1 → XP_038528775.1  galactocerebrosidase isoform X2

    UniProtKB/TrEMBL
    A0A8I3N8Q2
    Related
    ENSCAFP00845013402.1, ENSCAFT00845017197.1
    Conserved Domains (2) summary
    pfam02057
    Location:1 → 233
    Glyco_hydro_59; Glycosyl hydrolase family 59
    pfam17387
    Location:241 → 356
    Glyco_hydro_59M; Glycosyl hydrolase family 59 central domain

  3. XM_038672846.1 → XP_038528774.1  galactocerebrosidase isoform X1

    UniProtKB/TrEMBL
    A0A8I3NF27, A0A8P0NLV4
    Conserved Domains (3) summary
    pfam02057
    Location:70 → 353
    Glyco_hydro_59; Glycosyl hydrolase family 59
    pfam17387
    Location:361 → 476
    Glyco_hydro_59M; Glycosyl hydrolase family 59 central domain
    cl02099
    Location:3 → 32
    CK_II_beta; Casein kinase II regulatory subunit

  4. XM_038672848.1 → XP_038528776.1  galactocerebrosidase isoform X2

    UniProtKB/TrEMBL
    A0A8I3N8Q2
    Conserved Domains (2) summary
    pfam02057
    Location:1 → 233
    Glyco_hydro_59; Glycosyl hydrolase family 59
    pfam17387
    Location:241 → 356
    Glyco_hydro_59M; Glycosyl hydrolase family 59 central domain

  5. XM_038672844.1 → XP_038528772.1  galactocerebrosidase isoform X1

    UniProtKB/TrEMBL
    A0A8I3NF27, A0A8P0NLV4
    Related
    ENSCAFP00845013453.1, ENSCAFT00845017262.1
    Conserved Domains (3) summary
    pfam02057
    Location:70 → 353
    Glyco_hydro_59; Glycosyl hydrolase family 59
    pfam17387
    Location:361 → 476
    Glyco_hydro_59M; Glycosyl hydrolase family 59 central domain
    cl02099
    Location:3 → 32
    CK_II_beta; Casein kinase II regulatory subunit

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049268.1 Alternate UMICH_Zoey_3.1

    Range
    59214260..59271257 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049749.1 Alternate UNSW_CanFamBas_1.0

    Range
    59260650..59317658 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049229.1 Alternate UU_Cfam_GSD_1.0

    Range
    59594667..59651690 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006590.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    58846151..58903131 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P54804.1 GenPept UniProtKB/Swiss-Prot:P54804

Gene LinkOut

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Molecular Biology Databases
Research Materials