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F8 coagulation factor VIII [ Canis lupus familiaris (dog) ]

Gene ID: 403875, updated on 17-Aug-2024

Summary

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Official Symbol
F8provided by VGNC
Official Full Name
coagulation factor VIIIprovided by VGNC
Primary source
VGNC:VGNC:40553
See related
Ensembl:ENSCAFG00845030098
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: X
Exon count:
27
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) X NC_051843.1 (126024520..126170925, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) X NC_006621.4 (107890270..108036564, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) X NC_049260.1 (123987629..124161753, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) X NC_049299.1 (121771228..121918614, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) X NC_049780.1 (124294452..124441038, complement)

Chromosome X - NC_051843.1Genomic Context describing neighboring genes Neighboring gene MAGUK p55 scaffold protein 1 Neighboring gene small integral membrane protein 9 Neighboring gene H2A.B variant histone 1 Neighboring gene coagulation factor VIII associated 1 Neighboring gene thiamin pyrophosphokinase 1-like Neighboring gene FUN14 domain containing 2 Neighboring gene mature T cell proliferation 1 Neighboring gene C-X9-C motif containing 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Omental implantation of BOECs in hemophilia dogs results in circulating FVIII antigen and a complex immune response. Ozelo MC, et al. Blood, 2014 Jun 26. PMID 24829206
  2. The canine factor VIII cDNA and 5' flanking sequence. Cameron C, et al. Thromb Haemost, 1998 Feb. PMID 9493583
  3. Minimal modification in the factor VIII B-domain sequence ameliorates the murine hemophilia A phenotype. Siner JI, et al. Blood, 2013 May 23. PMID 23372167, Free PMC Article
  4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Omental implantation of BOECs in hemophilia dogs results in circulating FVIII antigen and a complex immune response
    Title: Omental implantation of BOECs in hemophilia dogs results in circulating FVIII antigen and a complex immune response.
  2. Recombinant canine B-domain deleted (BDD) factor VIII (FVIII) is predominantly expressed as a single-chain protein and exhibits greater stability after activation compared with human FVIII-BDD.
    Title: Minimal modification in the factor VIII B-domain sequence ameliorates the murine hemophilia A phenotype.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables copper ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
coagulation factor VIII
Names
coagulation co-factor
coagulation factor VIII, procoagulant component (hemophilia A)
factor VIII
procoagulant component

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003212.1 → NP_001003212.1  coagulation factor VIII precursor

    See identical proteins and their annotated locations for NP_001003212.1

    Status: PROVISIONAL

    Source sequence(s)
    AF049489
    UniProtKB/Swiss-Prot
    O18806, O62730
    Related
    ENSCAFP00845041989.1, ENSCAFT00845053442.1
    Conserved Domains (4) summary
    smart00231
    Location:2031 → 2180
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cd00057
    Location:2187 → 2336
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cd04227
    Location:393 → 569
    CuRO_3_FVIII_like; The third cupredoxin domain of coagulation factor VIII and similar proteins
    cl19115
    Location:1706 → 1872
    Cupredoxin; Cupredoxin superfamily

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051843.1 Reference ROS_Cfam_1.0

    Range
    126024520..126170925 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038448819.1 → XP_038304747.1  coagulation factor VIII isoform X1

    UniProtKB/TrEMBL
    A0A8C0TDF5, A0A8I3QF76, A0A8P0TCS5
    Related
    ENSCAFP00845042145.1, ENSCAFT00845053636.1
    Conserved Domains (3) summary
    cd00057
    Location:2034 → 2158
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cd04227
    Location:393 → 569
    CuRO_3_FVIII_like; The third cupredoxin domain of coagulation factor VIII and similar proteins
    cl19115
    Location:1706 → 1872
    Cupredoxin; Cupredoxin superfamily

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049299.1 Alternate UMICH_Zoey_3.1

    Range
    121771228..121918614 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049780.1 Alternate UNSW_CanFamBas_1.0

    Range
    124294452..124441038 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049260.1 Alternate UU_Cfam_GSD_1.0

    Range
    123987629..124161753 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006621.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    107890270..108036564 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O18806.1 GenPept UniProtKB/Swiss-Prot:O18806

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials