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GUCY2D guanylate cyclase 2D, retinal [ Canis lupus familiaris (dog) ]

Gene ID: 403863, updated on 17-Aug-2024

Summary

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Official Symbol
GUCY2Dprovided by VGNC
Official Full Name
guanylate cyclase 2D, retinalprovided by VGNC
Primary source
VGNC:VGNC:41570
See related
Ensembl:ENSCAFG00845027102
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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See GUCY2D in Genome Data Viewer
Location:
chromosome: 5
Exon count:
20
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 5 NC_051809.1 (32946524..32962026)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 5 NC_006587.4 (32980192..32995463)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 5 NC_049226.1 (33049385..33064860)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 5 NC_049265.1 (32913920..32929071)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 5 NC_049746.1 (32869724..32884891)

Chromosome 5 - NC_051809.1Genomic Context describing neighboring genes Neighboring gene centrobin, centriole duplication and spindle assembly protein Neighboring gene potassium voltage-gated channel subfamily A regulatory beta subunit 3 Neighboring gene trafficking protein particle complex subunit 1 Neighboring gene arachidonate 15-lipoxygenase type B Neighboring gene arachidonate 12-lipoxygenase, 12R type

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Organization of the canine gene encoding the E isoform of retinal guanylate cyclase (cGC-E) and exclusion of its involvement in the inherited retinal dystrophy of the Swedish Briard and Briard-beagle dogs. Veske A, et al. Biochim Biophys Acta, 1998 Jun 24. PMID 9651484
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables guanylate cyclase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables peptide receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cGMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in receptor guanylyl cyclase signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
retinal guanylyl cyclase 1
Names
GC-E
RETGC-1
ROS-GC
guanylate cyclase E
rod outer segment membrane guanylate cyclase
NP_001003207.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003207.1 → NP_001003207.1  retinal guanylyl cyclase 1 precursor

    See identical proteins and their annotated locations for NP_001003207.1

    Status: PROVISIONAL

    Source sequence(s)
    Y15483
    UniProtKB/Swiss-Prot
    O19179
    UniProtKB/TrEMBL
    A0A8C0NXQ6, A0A8P0SKZ7
    Related
    ENSCAFP00845037528.1, ENSCAFT00845047832.1
    Conserved Domains (7) summary
    smart00044
    Location:850 → 1040
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    cd14043
    Location:541 → 815
    PK_GC-2D; Pseudokinase domain of the membrane Guanylate Cyclase receptor, GC-2D
    pfam00211
    Location:875 → 1062
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam01094
    Location:91 → 422
    ANF_receptor; Receptor family ligand binding region
    pfam07701
    Location:824 → 869
    HNOBA; Heme NO binding associated
    pfam07714
    Location:559 → 801
    Pkinase_Tyr; Protein tyrosine kinase
    cl10011
    Location:59 → 435
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051809.1 Reference ROS_Cfam_1.0

    Range
    32946524..32962026
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049265.1 Alternate UMICH_Zoey_3.1

    Range
    32913920..32929071
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049746.1 Alternate UNSW_CanFamBas_1.0

    Range
    32869724..32884891
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049226.1 Alternate UU_Cfam_GSD_1.0

    Range
    33049385..33064860
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006587.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    32980192..32995463
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O19179.1 GenPept UniProtKB/Swiss-Prot:O19179

Gene LinkOut

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Molecular Biology Databases
Research Materials