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PDE6A phosphodiesterase 6A [ Canis lupus familiaris (dog) ]

Gene ID: 403620, updated on 17-Aug-2024

Summary

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Official Symbol
PDE6Aprovided by VGNC
Official Full Name
phosphodiesterase 6Aprovided by VGNC
Primary source
VGNC:VGNC:44357
See related
Ensembl:ENSCAFG00845008935
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
PDEA
Orthologs
human mouse all
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Genomic context

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See PDE6A in Genome Data Viewer
Location:
chromosome: 4
Exon count:
23
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 4 NC_051808.1 (59584148..59644927)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 4 NC_006586.4 (58869721..58929621)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 4 NC_049225.1 (60018959..60078866)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 4 NC_049264.1 (59373301..59433215)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 4 NC_049745.1 (59487640..59547674)

Chromosome 4 - NC_051808.1Genomic Context describing neighboring genes Neighboring gene tigger transposable element derived 6 Neighboring gene solute carrier family 26 member 2 Neighboring gene PPARG coactivator 1 beta Neighboring gene U6 spliceosomal RNA Neighboring gene microRNA mir-378

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of a canine model of autosomal recessive retinitis pigmentosa due to a PDE6A mutation. Tuntivanich N, et al. Invest Ophthalmol Vis Sci, 2009 Feb. PMID 18775863, Free PMC Article
  2. Exclusion of the PDE6A gene for generalised progressive retinal atrophy in 11 breeds of dog. Dekomien G, et al. Anim Genet, 2000 Apr. PMID 10782214
  3. cGMP phosphodiesterase-alpha mutation causes progressive retinal atrophy in the Cardigan Welsh corgi dog. Petersen-Jones SM, et al. Invest Ophthalmol Vis Sci, 1999 Jul. PMID 10393029
  4. Microsatellite (CA)n polymorphism in intron 2 of the canine rod photoreceptor cGMP-phosphodiesterase alpha-subunit gene. Veske A, et al. Anim Genet, 1997 Oct. PMID 9363616
  5. Cloning and characterization of the cDNA encoding the alpha-subunit of cGMP-phosphodiesterase in canine retinal rod photoreceptor cells. Wang W, et al. Mol Vis, 1996 May 9. PMID 9233984

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 3',5'-cyclic-nucleotide phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha
Names
GMP-PDE alpha
cGMP-phosphodiesterase alpha-subunit
rod specific cGMP phosphodiesterase, alpha subunit
NP_001003073.1
XP_038518137.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003073.1 → NP_001003073.1  rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha

    See identical proteins and their annotated locations for NP_001003073.1

    Status: PROVISIONAL

    Source sequence(s)
    U52868
    UniProtKB/TrEMBL
    A0A8C0M8N3
    Related
    ENSCAFP00845012309.1, ENSCAFT00845015823.1
    Conserved Domains (2) summary
    smart00065
    Location:254 → 441
    GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
    pfam00233
    Location:558 → 802
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051808.1 Reference ROS_Cfam_1.0

    Range
    59584148..59644927
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038662209.1 → XP_038518137.1  rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha isoform X1

    UniProtKB/TrEMBL
    A0A8C0M8N3
    Conserved Domains (2) summary
    smart00065
    Location:274 → 461
    GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
    pfam00233
    Location:578 → 822
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049264.1 Alternate UMICH_Zoey_3.1

    Range
    59373301..59433215
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049745.1 Alternate UNSW_CanFamBas_1.0

    Range
    59487640..59547674
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049225.1 Alternate UU_Cfam_GSD_1.0

    Range
    60018959..60078866
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006586.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    58869721..58929621
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q28263.2 GenPept UniProtKB/Swiss-Prot:Q28263

Gene LinkOut

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