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smarca2.L SWI/SNF related BAF chromatin remodeling complex subunit ATPase 2 L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 403380, updated on 4-Nov-2024

Summary

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Official Symbol
smarca2.L
Official Full Name
SWI/SNF related BAF chromatin remodeling complex subunit ATPase 2 L homeolog
Primary source
Xenbase:XB-GENE-1013848
Locus tag
XELAEV_18006846mg
See related
EnsemblRapid:ENSXLAG00005006303 AllianceGenome:Xenbase:XB-GENE-1013848
Gene type
protein coding
RefSeq status
MODEL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
brm; smarca2
Summary
Predicted to enable several functions, including ATP binding activity; ATP-dependent chromatin remodeler activity; and histone binding activity. Predicted to act upstream of or within chromatin remodeling; positive regulation of transcription by RNA polymerase II; and transcription elongation by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of RSC-type complex and SWI/SNF complex. Is expressed in anatomical system and pharyngeal arch. Human ortholog(s) of this gene implicated in Nicolaides-Baraitser syndrome and blepharophimosis-impaired intellectual development syndrome. Orthologous to human SMARCA2 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See smarca2.L in Genome Data Viewer
Location:
chromosome: 1L
Exon count:
40
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 1L NC_054371.1 (138857961..138971475, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 1L NC_030724.1 (126438041..126541379, complement)

Chromosome 1L - NC_054371.1Genomic Context describing neighboring genes Neighboring gene potassium channel, voltage gated modifier subfamily V, member 2 L homeolog Neighboring gene very low density lipoprotein receptor L homeolog Neighboring gene uncharacterized protein K02A2.6-like Neighboring gene doublesex- and mab-3-related transcription factor 2-like L homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent activity, acting on DNA IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent chromatin remodeler activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables chromatin binding IEA
Inferred from Electronic Annotation
more info
  
enables histone binding IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within transcription elongation by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of RSC-type complex IEA
Inferred from Electronic Annotation
more info
  
part_of SWI/SNF complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
probable global transcription activator SNF2L2
Names
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 L homeolog

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054371.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    138857961..138971475 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_041564111.1 → XP_041420045.1  probable global transcription activator SNF2L2 isoform X1

    UniProtKB/TrEMBL
    A0A8J1KRT0
    Conserved Domains (6) summary
    cd05516
    Location:1399 → 1505
    Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
    smart00592
    Location:591 → 635
    BRK; domain in transcription and CHROMO domain helicases
    smart00573
    Location:438 → 510
    HSA; domain in helicases and associated with SANT domains
    PLN03142
    Location:720 → 1202
    PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    PHA03378
    Location:46 → 384
    PHA03378; EBNA-3B; Provisional
    cd17996
    Location:721 → 951
    DEXHc_SMARCA2_SMARCA4; DEXH-box helicase domain of SMARCA2 and SMARCA4

  2. XM_041564110.1 → XP_041420044.1  probable global transcription activator SNF2L2 isoform X1

    UniProtKB/TrEMBL
    A0A8J1KRT0
    Conserved Domains (6) summary
    cd05516
    Location:1399 → 1505
    Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
    smart00592
    Location:591 → 635
    BRK; domain in transcription and CHROMO domain helicases
    smart00573
    Location:438 → 510
    HSA; domain in helicases and associated with SANT domains
    PLN03142
    Location:720 → 1202
    PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    PHA03378
    Location:46 → 384
    PHA03378; EBNA-3B; Provisional
    cd17996
    Location:721 → 951
    DEXHc_SMARCA2_SMARCA4; DEXH-box helicase domain of SMARCA2 and SMARCA4

  3. XM_041564125.1 → XP_041420059.1  probable global transcription activator SNF2L2 isoform X4

    UniProtKB/TrEMBL
    A0A8J1KV04
    Related
    ENSXLAP00005018768.1, ENSXLAT00005019103.1
    Conserved Domains (6) summary
    cd05516
    Location:1365 → 1471
    Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
    smart00592
    Location:557 → 601
    BRK; domain in transcription and CHROMO domain helicases
    smart00573
    Location:404 → 476
    HSA; domain in helicases and associated with SANT domains
    PLN03142
    Location:686 → 1168
    PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    PHA03378
    Location:46 → 350
    PHA03378; EBNA-3B; Provisional
    cd17996
    Location:687 → 917
    DEXHc_SMARCA2_SMARCA4; DEXH-box helicase domain of SMARCA2 and SMARCA4

  4. XM_041564117.1 → XP_041420051.1  probable global transcription activator SNF2L2 isoform X2

    UniProtKB/TrEMBL
    A0A8J1KRX2
    Conserved Domains (6) summary
    cd05516
    Location:1398 → 1504
    Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
    smart00592
    Location:590 → 634
    BRK; domain in transcription and CHROMO domain helicases
    smart00573
    Location:437 → 509
    HSA; domain in helicases and associated with SANT domains
    PLN03142
    Location:719 → 1201
    PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    PHA03378
    Location:46 → 383
    PHA03378; EBNA-3B; Provisional
    cd17996
    Location:720 → 950
    DEXHc_SMARCA2_SMARCA4; DEXH-box helicase domain of SMARCA2 and SMARCA4

  5. XM_041564108.1 → XP_041420042.1  probable global transcription activator SNF2L2 isoform X1

    UniProtKB/TrEMBL
    A0A8J1KRT0
    Related
    ENSXLAP00005018790.1, ENSXLAT00005019125.1
    Conserved Domains (6) summary
    cd05516
    Location:1399 → 1505
    Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
    smart00592
    Location:591 → 635
    BRK; domain in transcription and CHROMO domain helicases
    smart00573
    Location:438 → 510
    HSA; domain in helicases and associated with SANT domains
    PLN03142
    Location:720 → 1202
    PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    PHA03378
    Location:46 → 384
    PHA03378; EBNA-3B; Provisional
    cd17996
    Location:721 → 951
    DEXHc_SMARCA2_SMARCA4; DEXH-box helicase domain of SMARCA2 and SMARCA4

  6. XM_018258542.2 → XP_018114031.1  probable global transcription activator SNF2L2 isoform X7

    UniProtKB/TrEMBL
    A0A8J0V1K0
    Related
    ENSXLAP00005018828.1, ENSXLAT00005019163.1

  7. XM_018258507.2 → XP_018113996.1  probable global transcription activator SNF2L2 isoform X3

    UniProtKB/TrEMBL
    A0A1L8HY81, A0A974E004
    Related
    ENSXLAP00005018814.1, ENSXLAT00005019150.1

  8. XM_041564127.1 → XP_041420061.1  probable global transcription activator SNF2L2 isoform X6

    UniProtKB/TrEMBL
    A0A8J1KRY2
    Conserved Domains (1) summary
    cd05516
    Location:59 → 165
    Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...

  9. XM_018258560.2 → XP_018114049.1  probable global transcription activator SNF2L2 isoform X5

    UniProtKB/TrEMBL
    A0A8J0V2F8
Nucleotide Protein Strain
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