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cacna1da calcium channel, voltage-dependent, L type, alpha 1D subunit, a [ Danio rerio (zebrafish) ]

Gene ID: 403310, updated on 2-Nov-2024

Summary

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Official Symbol
cacna1daprovided by ZNC
Official Full Name
calcium channel, voltage-dependent, L type, alpha 1D subunit, aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030616-135
See related
Ensembl:ENSDARG00000102773 AllianceGenome:ZFIN:ZDB-GENE-030616-135
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
isl; cacna1d; cav1.3a; si:dz223c6.1; si:dz136d19.3
Summary
Predicted to enable high voltage-gated calcium channel activity. Acts upstream of or within detection of mechanical stimulus involved in sensory perception of sound; neuromuscular process controlling balance; and synapse organization. Located in basal plasma membrane and ribbon synapse. Is expressed in central nervous system; heart; and neuromast. Used to study schizophrenia. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human CACNA1D (calcium voltage-gated channel subunit alpha1 D). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See cacna1da in Genome Data Viewer
Location:
chromosome: 11
Exon count:
50
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (36788342..36964153, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (36531569..36696445, complement)

Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137496721 Neighboring gene parapinopsin b Neighboring gene uncharacterized LOC137496726 Neighboring gene uncharacterized LOC103911864 Neighboring gene transketolase a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Zebrafish Larvae Carrying a Splice Variant Mutation in cacna1d: A New Model for Schizophrenia-Like Behaviours? Banono NS, et al. Mol Neurobiol, 2021 Feb. PMID 33057948, Free PMC Article
  2. Presynaptic CaV1.3 channels regulate synaptic ribbon size and are required for synaptic maintenance in sensory hair cells. Sheets L, et al. J Neurosci, 2012 Nov 28. PMID 23197719, Free PMC Article
  3. Synaptic Ribbons Require Ribeye for Electron Density, Proper Synaptic Localization, and Recruitment of Calcium Channels. Lv C, et al. Cell Rep, 2016 Jun 21. PMID 27292637, Free PMC Article
  4. Characteristics of the New Insulin-Resistant Zebrafish Model. Nam YH, et al. Pharmaceuticals (Basel), 2021 Jul 4. PMID 34358068, Free PMC Article
  5. gemini encodes a zebrafish L-type calcium channel that localizes at sensory hair cell ribbon synapses. Sidi S, et al. J Neurosci, 2004 Apr 28. PMID 15115817, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables calcium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables high voltage-gated calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables voltage-gated calcium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables voltage-gated calcium channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in calcium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within calcium ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within detection of mechanical stimulus involved in sensory perception IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within detection of mechanical stimulus involved in sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within neuromuscular process controlling balance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within synapse organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in basal plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
part_of monoatomic ion channel complex IEA
Inferred from Electronic Annotation
more info
  
located_in ribbon synapse IDA
Inferred from Direct Assay
more info
 PubMed 
part_of voltage-gated calcium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of voltage-gated calcium channel complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
calcium channel, voltage-dependent, L type, alpha 1D subunit, a
Names
gem
gemini

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_203484.1 → NP_982351.1  calcium channel, voltage-dependent, L type, alpha 1D subunit, a

    See identical proteins and their annotated locations for NP_982351.1

    Status: PROVISIONAL

    Source sequence(s)
    AY528224
    UniProtKB/TrEMBL
    Q6QRQ2
    Related
    ENSDARP00000137557.2, ENSDART00000168288.2
    Conserved Domains (4) summary
    pfam00520
    Location:1165 → 1403
    Ion_trans; Ion transport protein
    pfam08763
    Location:1476 → 1547
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16885
    Location:1572 → 2079
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
    pfam16905
    Location:1411 → 1474
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007122.7 Reference GRCz11 Primary Assembly

    Range
    36788342..36964153 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068224136.1 → XP_068080237.1  calcium channel, voltage-dependent, L type, alpha 1D subunit, a isoform X7

    Related
    ENSDARP00000134024.3, ENSDART00000168528.3

  2. XM_021479584.2 → XP_021335259.1  calcium channel, voltage-dependent, L type, alpha 1D subunit, a isoform X10

    UniProtKB/TrEMBL
    A0A8M9QD08
    Conserved Domains (4) summary
    pfam00520
    Location:1125 → 1378
    Ion_trans; Ion transport protein
    pfam08763
    Location:1451 → 1522
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16885
    Location:1547 → 2056
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
    pfam16905
    Location:1379 → 1449
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  3. XM_021479581.2 → XP_021335256.1  calcium channel, voltage-dependent, L type, alpha 1D subunit, a isoform X6

    UniProtKB/TrEMBL
    A0A8M9QHK6
    Conserved Domains (4) summary
    pfam00520
    Location:1125 → 1389
    Ion_trans; Ion transport protein
    pfam08763
    Location:1462 → 1533
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16885
    Location:1558 → 2067
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
    pfam16905
    Location:1390 → 1460
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  4. XM_021479580.2 → XP_021335255.1  calcium channel, voltage-dependent, L type, alpha 1D subunit, a isoform X5

    UniProtKB/TrEMBL
    A0A8M9QLJ7
    Conserved Domains (4) summary
    pfam00520
    Location:1150 → 1403
    Ion_trans; Ion transport protein
    pfam08763
    Location:1476 → 1547
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16885
    Location:1572 → 2081
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
    pfam16905
    Location:1404 → 1474
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  5. XM_021479577.2 → XP_021335252.1  calcium channel, voltage-dependent, L type, alpha 1D subunit, a isoform X2

    UniProtKB/TrEMBL
    A0A8M9PUS4
    Conserved Domains (4) summary
    pfam00520
    Location:1150 → 1414
    Ion_trans; Ion transport protein
    pfam08763
    Location:1487 → 1558
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16885
    Location:1583 → 2092
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
    pfam16905
    Location:1415 → 1485
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  6. XM_068224137.1 → XP_068080238.1  calcium channel, voltage-dependent, L type, alpha 1D subunit, a isoform X8

  7. XM_021479583.2 → XP_021335258.1  calcium channel, voltage-dependent, L type, alpha 1D subunit, a isoform X9

    UniProtKB/TrEMBL
    A0A8M9Q745
    Conserved Domains (4) summary
    pfam00520
    Location:1150 → 1414
    Ion_trans; Ion transport protein
    pfam08763
    Location:1487 → 1558
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16885
    Location:1756 → 2053
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
    pfam16905
    Location:1415 → 1485
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  8. XM_021479579.2 → XP_021335254.1  calcium channel, voltage-dependent, L type, alpha 1D subunit, a isoform X4

    UniProtKB/TrEMBL
    A0A8M9QD03
    Conserved Domains (4) summary
    pfam00520
    Location:1150 → 1414
    Ion_trans; Ion transport protein
    pfam08763
    Location:1487 → 1558
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16885
    Location:1583 → 2083
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
    pfam16905
    Location:1415 → 1485
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  9. XM_021479578.2 → XP_021335253.1  calcium channel, voltage-dependent, L type, alpha 1D subunit, a isoform X3

    UniProtKB/TrEMBL
    A0A8M9Q738
    Conserved Domains (4) summary
    pfam00520
    Location:1150 → 1414
    Ion_trans; Ion transport protein
    pfam08763
    Location:1487 → 1558
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16885
    Location:1583 → 2091
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
    pfam16905
    Location:1415 → 1485
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  10. XM_021479576.2 → XP_021335251.1  calcium channel, voltage-dependent, L type, alpha 1D subunit, a isoform X1

    UniProtKB/TrEMBL
    A0A8M9QHK0
    Conserved Domains (4) summary
    pfam00520
    Location:1150 → 1414
    Ion_trans; Ion transport protein
    pfam08763
    Location:1487 → 1558
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16885
    Location:1583 → 2092
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
    pfam16905
    Location:1415 → 1485
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
Nucleotide Protein Strain
Heading Accession and Version

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