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HMGB1 high mobility group box 1 [ Canis lupus familiaris (dog) ]

Gene ID: 403170, updated on 19-Oct-2024

Summary

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Official Symbol
HMGB1provided by VGNC
Official Full Name
high mobility group box 1provided by VGNC
Primary source
VGNC:VGNC:59082
See related
Ensembl:ENSCAFG00845021967
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
HMG1
Orthologs
human mouse all
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Genomic context

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See HMGB1 in Genome Data Viewer
Location:
chromosome: 25
Exon count:
7
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 25 NC_051829.1 (9542952..9670011)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 25 NC_006607.4 (9596948..9603279)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 25 NC_049246.1 (9608257..9614621)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 25 NC_049285.1 (9558389..9564743)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 25 NC_049766.1 (9566227..9572605)

Chromosome 25 - NC_051829.1Genomic Context describing neighboring genes Neighboring gene U4 spliceosomal RNA Neighboring gene ubiquitin specific peptidase like 1 Neighboring gene uncharacterized LOC102155494 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC111092316

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. TNF-α induced secretion of HMGB1 from non-immune canine mammary epithelial cells (MTH53A). Willenbrock S, et al. Cytokine, 2012 Feb. PMID 22154216
  2. Quantitative PCR and immunohistochemical analyses of HMGB1 and RAGE expression in canine disseminated histiocytic sarcoma (malignant histiocytosis). Sterenczak KA, et al. Anticancer Res, 2011 May. PMID 21617208
  3. Molecular characterization of the canine HMGB1. Murua Escobar H, et al. Cytogenet Genome Res, 2003. PMID 14571134
  4. Light-activated BioID - an optically activated proximity labeling system to study protein-protein interactions. Shafraz O, et al. J Cell Sci, 2023 Oct 1. PMID 37756605, Free PMC Article
  5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The observed HMGB1 release kinetics showed a clearly time-dependent manner with a peak release 24h after TNF-alpha stimulation, while stimulation with IFN-gamma had only small effects on the HMGB1 release.
    Title: TNF-α induced secretion of HMGB1 from non-immune canine mammary epithelial cells (MTH53A).
  2. RAGE and HMGB1 expression down-regulation in canine disseminated histiocytic sarcoma points to a role in the progression of histiocytic disorders
    Title: Quantitative PCR and immunohistochemical analyses of HMGB1 and RAGE expression in canine disseminated histiocytic sarcoma (malignant histiocytosis).
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA binding, bending IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
high mobility group protein B1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002937.2 → NP_001002937.1  high mobility group protein B1

    See identical proteins and their annotated locations for NP_001002937.1

    Status: VALIDATED

    Source sequence(s)
    AY135519, DN349572, DN355565, DN878449, JAAUVH010000302
    UniProtKB/Swiss-Prot
    Q6YKA4
    UniProtKB/TrEMBL
    A0A8C0R7L8
    Related
    ENSCAFP00845030356.1, ENSCAFT00845038767.1
    Conserved Domains (2) summary
    pfam00505
    Location:95 → 162
    HMG_box; HMG (high mobility group) box
    pfam09011
    Location:6 → 78
    HMG_box_2; HMG-box domain

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051829.1 Reference ROS_Cfam_1.0

    Range
    9542952..9670011
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038434508.1 → XP_038290436.1  high mobility group protein B1 isoform X1

    UniProtKB/Swiss-Prot
    Q6YKA4
    UniProtKB/TrEMBL
    A0A8C0R7L8
    Conserved Domains (2) summary
    pfam00505
    Location:95 → 162
    HMG_box; HMG (high mobility group) box
    pfam09011
    Location:6 → 78
    HMG_box_2; HMG-box domain

  2. XM_038434506.1 → XP_038290434.1  high mobility group protein B1 isoform X1

    UniProtKB/Swiss-Prot
    Q6YKA4
    UniProtKB/TrEMBL
    A0A8C0R7L8
    Conserved Domains (2) summary
    pfam00505
    Location:95 → 162
    HMG_box; HMG (high mobility group) box
    pfam09011
    Location:6 → 78
    HMG_box_2; HMG-box domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049285.1 Alternate UMICH_Zoey_3.1

    Range
    9558389..9564743
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049766.1 Alternate UNSW_CanFamBas_1.0

    Range
    9566227..9572605
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049246.1 Alternate UU_Cfam_GSD_1.0

    Range
    9608257..9614621
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006607.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    9596948..9603279
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6YKA4.3 GenPept UniProtKB/Swiss-Prot:Q6YKA4

Gene LinkOut

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