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lhcgr luteinizing hormone/choriogonadotropin receptor [ Danio rerio (zebrafish) ]

Gene ID: 402920, updated on 2-Nov-2024

Summary

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Official Symbol
lhcgrprovided by ZNC
Official Full Name
luteinizing hormone/choriogonadotropin receptorprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040806-3
See related
Ensembl:ENSDARG00000026081 AllianceGenome:ZFIN:ZDB-GENE-040806-3
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
lhr; GTHR-II; zfGTHR-II
Summary
Enables luteinizing hormone receptor activity. Acts upstream of or within several processes, including gonad development; luteinizing hormone signaling pathway; and ovulation. Predicted to be located in basolateral plasma membrane and lateral plasma membrane. Predicted to be active in plasma membrane. Is expressed in digestive system; endocrine system; female organism; and gonad. Human ortholog(s) of this gene implicated in Leydig cell hypoplasia; Leydig cell tumor; breast cancer; familial male-limited precocious puberty; and gonadal disease. Orthologous to human LHCGR (luteinizing hormone/choriogonadotropin receptor). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See lhcgr in Genome Data Viewer
Location:
chromosome: 13
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (47573473..47618843)
105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (47283648..47329018)

Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene acyl-CoA oxidase-like Neighboring gene uncharacterized LOC137487445 Neighboring gene c-mer proto-oncogene tyrosine kinase a Neighboring gene transmembrane protein 87B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Luteinizing hormone receptor (lhcgr) as a marker gene for characterizing estrogenic endocrine-disrupting chemicals in zebrafish ovarian follicle cells. Liu KC, et al. Gen Comp Endocrinol, 2013 Oct 1. PMID 23851042
  2. Characterization of inhibin alpha subunit (inha) in the zebrafish: evidence for a potential feedback loop between the pituitary and ovary. Poon SK, et al. Reproduction, 2009 Oct. PMID 19602521
  3. The gonadotropin receptors FSH-R and LH-R of Atlantic halibut (Hippoglossus hippoglossus), 1: isolation of multiple transcripts encoding full-length and truncated variants of FSH-R. Kobayashi T, et al. Gen Comp Endocrinol, 2008 May 1. PMID 18359484
  4. Insulin-like growth factor 3 is involved in oocyte maturation in zebrafish. Li J, et al. Biol Reprod, 2011 Mar. PMID 21084715
  5. Biochemical and histological alterations in adult zebrafish（Danio rerio）ovary following exposure to the tetronic acid insecticide spirotetramat. Wu H, et al. Ecotoxicol Environ Saf, 2018 Nov 30. PMID 30107324

See all (145) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that double mutation of follicle-stimulating hormone receptor (fshr) and luteinizing hormone receptor (lhcgr) resulted in infertile males
    Title: Disruption of Zebrafish Follicle-Stimulating Hormone Receptor (fshr) But Not Luteinizing Hormone Receptor (lhcgr) Gene by TALEN Leads to Failed Follicle Activation in Females Followed by Sexual Reversal to Males.
  2. Data show for the first time in a vertebrate species that Leydig cells as well as Sertoli cells express the mRNAs for both fshr and lhcgr.
    Title: Studies in zebrafish reveal unusual cellular expression patterns of gonadotropin receptor messenger ribonucleic acids in the testis and unexpected functional differentiation of the gonadotropins.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables G protein-coupled peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables luteinizing hormone receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables luteinizing hormone receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables luteinizing hormone receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-hormone receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables thyroid-stimulating hormone receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within female gonad development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in hormone-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in luteinizing hormone signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within luteinizing hormone signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in male gonad development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within male gonad development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ovarian follicle development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within ovulation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ovulation cycle process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within spermatogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in lateral plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
lutropin-choriogonadotropic hormone receptor
Names
luteinizing hormone receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_205625.1 → NP_991188.1  lutropin-choriogonadotropic hormone receptor precursor

    See identical proteins and their annotated locations for NP_991188.1

    Status: PROVISIONAL

    Source sequence(s)
    AY424302
    UniProtKB/TrEMBL
    Q6TCF8
    Related
    ENSDARP00000088230.3, ENSDART00000097459.4
    Conserved Domains (4) summary
    sd00033
    Location:47 → 70
    LRR_RI; leucine-rich repeat [structural motif]
    pfam00001
    Location:386 → 633
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam12369
    Location:283 → 356
    GnHR_trans; Gonadotropin hormone receptor transmembrane region
    pfam13306
    Location:58 → 216
    LRR_5; Leucine rich repeats (6 copies)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007124.7 Reference GRCz11 Primary Assembly

    Range
    47573473..47618843
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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