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Tdh L-threonine dehydrogenase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40268, updated on 2-Nov-2024

Summary

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Official Symbol
Tdhprovided by FlyBase
Official Full Name
L-threonine dehydrogenaseprovided by FlyBase
Primary source
FLYBASE:FBgn0036997
Locus tag
Dmel_CG5955
See related
AllianceGenome:FB:FBgn0036997
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG5955; Dmel\CG5955
Summary
Predicted to enable L-threonine 3-dehydrogenase activity. Predicted to be involved in threonine catabolic process. Is expressed in adult head. Orthologous to human TDH (L-threonine dehydrogenase (pseudogene)). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See Tdh in Genome Data Viewer
Location:
77C4-77C4; 3-47 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (20466944..20469592)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (20460044..20462692)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene artichoke Neighboring gene magro Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene iso Glutaminyl cyclase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Nutritional geometry framework of sleep. Lai ML, et al. Life Sci, 2023 Mar 1. PMID 36640899
  2. The extracellular matrix protein artichoke is required for integrity of ciliated mechanosensory and chemosensory organs in Drosophila embryos. Andrés M, et al. Genetics, 2014 Apr. PMID 24496014, Free PMC Article
  3. Serine metabolism in the brain regulates starvation-induced sleep suppression in Drosophila melanogaster. Sonn JY, et al. Proc Natl Acad Sci U S A, 2018 Jul 3. PMID 29915051, Free PMC Article
  4. Time-restricted feeding promotes muscle function through purine cycle and AMPK signaling in Drosophila obesity models. Livelo C, et al. Nat Commun, 2023 Feb 21. PMID 36810287, Free PMC Article
  5. Sleep-promoting effects of threonine link amino acid metabolism in Drosophila neuron to GABAergic control of sleep drive. Ki Y, et al. Elife, 2019 Jul 17. PMID 31313987, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables L-threonine 3-dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in threonine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
L-threonine dehydrogenase
Names
CG5955-PA
L-threonine 3-dehydrogenase, mitochondrial
Tdh-PA
NP_649230.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    20466944..20469592
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_140973.3 → NP_649230.1  L-threonine dehydrogenase [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649230.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VPE8
    Related
    FBpp0077855
    Conserved Domains (2) summary
    cd05272
    Location:47 → 351
    TDH_SDR_e; L-threonine dehydrogenase, extended (e) SDRs
    COG0451
    Location:47 → 355
    WcaG; Nucleoside-diphosphate-sugar epimerase [Cell wall/membrane/envelope biogenesis]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VPE8 Q9VPE8

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